ID G1U0R8_RABIT Unreviewed; 1659 AA.
AC G1U0R8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=ABC transporter domain-containing protein {ECO:0000259|PROSITE:PS50893};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000022949.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000022949.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000022949.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000022949.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000022949.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AAGW02061407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02061408; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02061409; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; G1U0R8; -.
DR STRING; 9986.ENSOCUP00000022949; -.
DR PaxDb; 9986-ENSOCUP00000022949; -.
DR Ensembl; ENSOCUT00000029136.3; ENSOCUP00000022949.3; ENSOCUG00000027125.3.
DR eggNOG; KOG0059; Eukaryota.
DR GeneTree; ENSGT00940000162242; -.
DR HOGENOM; CLU_000604_19_1_1; -.
DR InParanoid; G1U0R8; -.
DR TreeFam; TF105191; -.
DR Proteomes; UP000001811; Chromosome 6.
DR Bgee; ENSOCUG00000027125; Expressed in testis and 10 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR PANTHER; PTHR19229:SF243; ATP-BINDING CASSETTE, SUB-FAMILY A (ABC1), MEMBER 15; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 24..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 300..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 439..458
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 890..910
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1052..1073
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1093..1120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1132..1156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1162..1180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1258..1276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 505..738
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1336..1569
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 831..850
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1027..1048
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1659 AA; 189279 MW; 07FDC38CE0A07328 CRC64;
MAWLEFRAFR SLLWKNFILK KRRIINLLTE IFLTIVFGVG ILLARKFVVV KKNGPFNYSA
QQVDNVPTFI GAPATTPYPW ELAYVPSKST AVQNIVENVK DNLNSNMKVL GFSSEREFED
YVKQNNKTKN VLAGIVFDHD FQNSNDPLPL KVKYHLRFSS FKKNSRKFAT QLEEESWLTN
SLFPSMPSMG PRNQHDALGG NPGYISEGFL AVQHALDKAI MRHHNNTATE TLFNGVKIFV
QRFPYPSYYH DVFFLFAIVF IPLIIVCIFS MNHLTIIQSI VWEKENRLKE YQLMIGLSNW
MLWTAYFFTF ILLYFIIIII ICIILYIKAI LEYSDPIIVF IFLLFYTMPS ICFSFMVSTF
FSNAYFAITL GGFCFFITYL PAANLSVNYG QMTFNQKIVS CLSSNYAMAL GFKFIFDAEV
KKTGIKWNNI FSPNKQDNFL FAYILGMLLL DALLYFIVTW YVEAVYPGKY GVPKPWNFFL
QVMIVFLFHS YKYFEAEPTD LVTGITIKHL HKVFQDKGTT KVAIKELSLN LYEGQITVLL
GHNGAGKSTT MSILSGLYPP TSGEAYVYGY DISTQMVQIR KSLGLCPQQD LLFNYLTVSE
HLQFYSAIKG IPQKKCLKEI DHMLSAFNLL EKRDAFSKSL SGGMKRKLSI IIALLGDSKV
VILDEPTSGM DPASRRATWD LLQNYKQNRT MLLTTHYMDE ADVLGDRIAI MVQGYLQCCG
SSIFLKKLYG VGYHIVMVKE PHCNVEEVTK LIHYYAPAAT MESNVGTELS FTLPKEYAHR
FETLFTALEK RQEKLGIASF GASITTMEEV FLRVSHMENV PEDILAMQPP SQMSQPTMNQ
NRNASDVQGV HSPTLNESSI RFNTGCSLYC QQFRAMFLKR IMFSWRNWKL VLVQVLGLAA
SFAFLFEVAN PSNAEEKARK MDLGEYGQTI VPYSISGNSD LTTNFLKLLE SKLISEKQKL
KEVKGDLLNF LMENSDNRLY IIALSIEVKT NETVFTVLFN NEAYHSPSVA LAVLDNVLSM
SVSGKDASLT VSNKPQPRPN SKDKERTENG NMVASNIQLG VAILISGFCL LTVTEKTSKA
KHIQFLSGTS VFVYWISALL CDFIIFFISF LLLMIVFRYY KLNIYIMEYH ILETMLIFTL
FGWSAIPLTY LLSFLFSGST SAYVKLILFN YFSGTICILI DNSVDISNLS NGTKQFLRNL
LLLFPNYNLA KCLSEYTNIY SLKILCNALK TPSAYLNCSK ENTKKTIYSL EKGMLGKYFI
IMGIAGFLFL LFILLWESTF WRVRTFLNQQ VFFRIYKKFK KEQVSKKLSG KSEDEDVQNE
RINILQHPEK FQNSVVLIKE LTKIYFKYPV ILAVKNISLA IQKKECFGLL GFNGAGKTST
FQILTGEESA TSGDVFIDGF SINRNVLQVR SRIGYCPQFD ALLEYMTARE ILIMYARVWG
VSESQIQLYV NSYLNSMELE PHANKIISTY SGGNKRRLST AIALMGRSSV VFLDEPSTGM
DPVARRLLWN VVTKTRDSGK AIVITSHSME ECDALCTRLA IMVKGKFMCL GSPQHLKNKF
GNIYILKVKG KSEHMLEPFK NFIKMTFQGS DLKHQNQKIL NYYIPCKDNG WGKMFGILEK
AKEQFDLEDY SISQITLEQV FLTFANPENT DDDSLQKVP
//
