ID G1U124_RABIT Unreviewed; 396 AA.
AC G1U124;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=MYCL proto-oncogene, bHLH transcription factor {ECO:0000313|Ensembl:ENSOCUP00000023057.1};
GN Name=MYCL {ECO:0000313|Ensembl:ENSOCUP00000023057.1};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000023057.1, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000023057.1, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000023057.1,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000023057.1}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000023057.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein. Binds DNA as a heterodimer with MAX.
CC {ECO:0000256|ARBA:ARBA00025872}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR001705}.
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DR EMBL; AAGW02003111; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002715238.1; XM_002715192.3.
DR AlphaFoldDB; G1U124; -.
DR SMR; G1U124; -.
DR STRING; 9986.ENSOCUP00000023057; -.
DR PaxDb; 9986-ENSOCUP00000023057; -.
DR Ensembl; ENSOCUT00000028294.3; ENSOCUP00000023057.1; ENSOCUG00000025113.3.
DR GeneID; 100340331; -.
DR KEGG; ocu:100340331; -.
DR CTD; 4610; -.
DR eggNOG; ENOG502QWSU; Eukaryota.
DR GeneTree; ENSGT00940000158613; -.
DR HOGENOM; CLU_052560_0_0_1; -.
DR InParanoid; G1U124; -.
DR OMA; ATQSCHP; -.
DR OrthoDB; 3039999at2759; -.
DR Proteomes; UP000001811; Chromosome 13.
DR Bgee; ENSOCUG00000025113; Expressed in skin of back and 13 other cell types or tissues.
DR GO; GO:0005694; C:chromosome; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0045607; P:regulation of inner ear auditory receptor cell differentiation; IEA:Ensembl.
DR CDD; cd11457; bHLHzip_L-Myc; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR002418; Tscrpt_reg_Myc.
DR InterPro; IPR012682; Tscrpt_reg_Myc_N.
DR PANTHER; PTHR45851; MYC PROTO-ONCOGENE; 1.
DR PANTHER; PTHR45851:SF5; PROTEIN L-MYC-RELATED; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF01056; Myc_N; 2.
DR PIRSF; PIRSF001705; Myc_protein; 2.
DR PRINTS; PR00044; LEUZIPPRMYC.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR001705};
KW Nucleus {ECO:0000256|PIRNR:PIRNR001705};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 313..365
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 69..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 143..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..288
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..323
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 396 AA; 43222 MW; 9DE4818F8E45C59D CRC64;
MCVCAGCRAA PSRRGAGPLQ VAGGGSEGAD MDFDSYQHYF YDYDCGEDFH RSTAPSEDIW
KKFELVPSPP TSPPWGSGPG AGDPASGIGP PETWPGGGAG DEAESRGHSK AWGRNYASII
RRDCMWSGFS ARERLERVVS DRLAPGAPRG NPPKAPAAPD CTPSLEVGNP QPAAPCQLGE
PKTQACSGSE SPSDSEGEEI DVVTVEKRQS LGIRKPVTIT VRADLLDPCM KHFHISIHQQ
QHNYAARFPP ESCSQEGAPE GAPPEEALDR DAPEEKEDEE EEDDEMVSSP PAESQASQSC
HPKPISSDSE DVTKRKNHNF LERKRRNDLR SRFLALRDQV PTLASCSKAP KVVILSKALE
YLQALVGAEK RMATEKRQLR CRQQQLQRRI AYLSGY
//
