ID G1U432_RABIT Unreviewed; 1724 AA.
AC G1U432;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 24-JAN-2024, entry version 68.
DE RecName: Full=Laminin G domain-containing protein {ECO:0000259|PROSITE:PS50025};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000024149.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000024149.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000024149.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000024149.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000024149.3};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR EMBL; AAGW02030802; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02030803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02030804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02030805; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; G1U432; -.
DR STRING; 9986.ENSOCUP00000024149; -.
DR PaxDb; 9986-ENSOCUP00000024149; -.
DR Ensembl; ENSOCUT00000021530.3; ENSOCUP00000024149.3; ENSOCUG00000027987.3.
DR eggNOG; KOG3597; Eukaryota.
DR GeneTree; ENSGT00940000154091; -.
DR HOGENOM; CLU_000473_1_0_1; -.
DR InParanoid; G1U432; -.
DR TreeFam; TF316876; -.
DR Proteomes; UP000001811; Chromosome 11.
DR Bgee; ENSOCUG00000027987; Expressed in skeletal muscle tissue and 14 other cell types or tissues.
DR CDD; cd00110; LamG; 2.
DR Gene3D; 2.60.120.200; -; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR45739:SF1; EXTRACELLULAR MATRIX ORGANIZING PROTEIN FRAS1; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 11.
DR Pfam; PF02210; Laminin_G_2; 2.
DR SMART; SM00282; LamG; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR PROSITE; PS51854; CSPG; 10.
DR PROSITE; PS50025; LAM_G_DOMAIN; 2.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1724
FT /note="Laminin G domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023926150"
FT DOMAIN 24..199
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 209..388
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REPEAT 425..521
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 550..645
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 662..760
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 779..874
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 894..988
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1131..1222
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1242..1340
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1358..1449
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1473..1563
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1580..1680
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
SQ SEQUENCE 1724 AA; 193906 MW; F67DBC046C67F475 CRC64;
MGRPGARRLA LLTACLGLCA ARAVLGASFY GESYVELNIL ESSSELSLQF KFQTSKPQGL
LFLAAGKSDY CILELLSGTL RVRVNLGTGE QVLLSEQRLH MDDLVWHFVE LYCVKDNISL
IIDKHYKTTE QIAGGMPRLS FQHGIYIGGH GGLNVPYIDG EFPNFRGCME DVIFNQREIL
KSLRSYPGFK KVYEVSLGCS DEFFAGQDEA INFFSSRSYV TFTEWKVQRK GLLEFALQSG
TQQALLLFQS GREGDFVALE IHEGLLKAHV GRGTSKAQLS SSCVVNDNKW HVIQLKFMGR
YLDLIVDKQG ERTLLPLQSK PFVSEGPLFL GGLDNRMREE AKRLELASVP RKSARGISFK
GCLRGLEVNS EKRALRDALV SKDISAGCKS SINPSLTTVE NLLQSEVSCS TGIPETIKPS
LQDEISHFLV LSNLEVQEGG RALLEQKHIR LNVEFEDLGL HHSQVLFKIE EMPTHGFFQL
DVSPEKNVEK AFTLLDLWQG KVWYVHDGSE ESTDHFTFSI SSKSKKEMPL YLQDHAAHVF
HITVLPVNDP PYLKLPEGNL LLLFENSRKR VTPDVIHVSD PDTDSLSLSF SVLGNFNSDA
GFLENARDRG KAISGFTQKD LRDGNVFYVH RGHRNSRIVL RASDGELVSN TVVLRVMAVP
WDFEVANRTG VVVQQGGTVL ITRSNLSVVV NGQLPEMQTR YEITRPPQFG QVQRQGSNGE
WKQVSTFSQH AIDRSRVRYW STVKALQLEN VTDYFKFKVN VEGKVNEELM FPVTIQWLKF
MLLKNVPLEI TQKNKQVLSS DHLRATTEGV EVAEEGLHFK LLTPPTKGKL LLGNKVLKTN
SVFSQRDITD AKISYEPQER PKEDSQDNFR FLIIAKHIES KDYTFRINFK ADKVHIILTN
KELLVKEGEG KVITKSELFV QTLDNQIFQY KITKSPQHGK LKLISFTDSL ENSDNVTAFT
DQDIVGERLM YVHDDSETQY DEFFIVASTK GPDQEEVVRD LDLEPLSTEI QVTISVELKN
DEKPVRVVDK VFHVVRNGQR LLTQEDLCYH DPDLDFDDGQ LLYTRRGIPN GDLVQASDPT
QKLYKFRQED LWEGHVLFKH WGADSARFVL FVTDGVHYTS SLLEVSASDP YVQVANNTGL
LVQRGQEGSV TTANLSVTTN QDVRTDHEIK FHIVQPPKHG RVLVNKTVSH SFSQHDLKQG
YVIYRHDGSG DFDVFNLTVK VKDVYLEVEV YVQVCLDGYQ HHTHILQRKT LVVEEGKPVK
LSRGKFQAGN EDNFPSEAMF IVRTPPMHGF LQKSIAQEDS LNTEERSPLV FTQQDVNAGH
ILYIQTVPGQ QQDRFSLDVM TGSQVVSAVE ILVDIVPKWI PLEVRNFTVQ EGGSKALLQD
HLKIPSQYFE GLDCEFVLLE PPKHGYIESS DLPRIKLMKF TRKQVENELI YYVHDDSEEL
LDNFTIFVNS SELGKQSLPQ TLYVTVESIN DEAPVITANK ILQVWANSVT EITSGDLHAE
DRDSLPQDLA YWVTPPSNGH LALKSFPGRS IQNFTQAQIN EGQLVFVHTG AMSGGFSFQV
TDGSNFAPRQ IFSITARALT ISLEVNRGLH IFPGSTKPLS SHDLRAVTND VDGAGNRTVT
FTVVSSPRLG RLVRMSSDNC TEDVSVFTQH LVNEGQIFYQ HVDCEDAAWT VQDSFTFTVS
SPPAALGPEE FRVTISYEIN EPGRQSQLLA NTGNATKTLP VPSL
//