ID G1U5J7_RABIT Unreviewed; 487 AA.
AC G1U5J7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=IF rod domain-containing protein {ECO:0000259|PROSITE:PS51842};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000024679.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000024679.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000024679.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000024679.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000024679.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; AAGW02059017; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002711243.1; XM_002711197.2.
DR AlphaFoldDB; G1U5J7; -.
DR SMR; G1U5J7; -.
DR PaxDb; 9986-ENSOCUP00000024679; -.
DR Ensembl; ENSOCUT00000031443.2; ENSOCUP00000024679.2; ENSOCUG00000026324.2.
DR GeneID; 100351237; -.
DR KEGG; ocu:100351237; -.
DR eggNOG; ENOG502RTZU; Eukaryota.
DR GeneTree; ENSGT00940000161838; -.
DR HOGENOM; CLU_012560_5_0_1; -.
DR InParanoid; G1U5J7; -.
DR OrthoDB; 4640531at2759; -.
DR TreeFam; TF317854; -.
DR Proteomes; UP000001811; Chromosome 4.
DR Bgee; ENSOCUG00000026324; Expressed in autopod skin and 2 other cell types or tissues.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF52; KERATIN, TYPE II CUTICULAR HB6; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR SUPFAM; SSF46579; Prefoldin; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 107..418
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 125..250
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 316..396
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 487 AA; 53353 MW; B2B21FBD6C97D946 CRC64;
MTCGSYCAGR AFSCASACGP RPGRCCITAA PYRGVACYRG LSGGFGSRSL CGGGFRAGSC
GRSFGYRSGG VCGPSAPCIT TVSVNESLLT PLNLEIDPNA QCVKHEEKEQ IKCLNSKFAA
FIDKVRFLEQ QNKLLETKLQ FFQNRKCCES NLEPLFEGYI ETLRREAECV EADSGRLSSE
LNHVQEVLEG YKKKYEEEVS LRATAENEFV ALKKDVDCAY LRRSDLEANV EALTEEIDFL
RQLYEEEIRV LHAHISDTSV VVKMDNSRDL NMDCVIAEIK AQYDDIATRS RAEAESWYRS
KCEEMKATVI RHGETLRRTK EEINELNRMI QRLTAEVENA KCQNTKLEAA VTQSEQQGEA
ALSDARCKLA GLEEALQKAK QDMACLLKEY QEVMNSKLGL DIEIATYRRL LEGEEQRLCE
GVGSVNVCVS SSRGGVVCGD LCATGTAPAV NTRVCSAPCS GNVVVGTPNA CAPCAAVSTC
GSVCKKC
//
