GenomeNet

Database: UniProt
Entry: G1U7D3_RABIT
LinkDB: G1U7D3_RABIT
Original site: G1U7D3_RABIT 
ID   G1U7D3_RABIT            Unreviewed;      5015 AA.
AC   G1U7D3;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   30-AUG-2017, entry version 40.
DE   SubName: Full=Ryanodine receptor 1 {ECO:0000313|Ensembl:ENSOCUP00000025335};
GN   Name=RYR1 {ECO:0000313|Ensembl:ENSOCUP00000025335};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000025335, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Ensembl:ENSOCUP00000025335, ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSOCUP00000025335}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000025335};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOCUP00000025335}.
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DR   EMBL; AAGW02068276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02068277; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02068278; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02068279; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02068280; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02068281; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02068282; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02068283; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02068284; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02068285; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9986.ENSOCUP00000025335; -.
DR   Ensembl; ENSOCUT00000031172; ENSOCUP00000025335; ENSOCUG00000023161.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; G1U7D3; -.
DR   OMA; DIPARRN; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000001811; Chromosome 5.
DR   Bgee; ENSOCUG00000023161; -.
DR   GO; GO:0005938; C:cell cortex; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0031674; C:I band; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030314; C:junctional membrane complex; IEA:Ensembl.
DR   GO; GO:0016020; C:membrane; IDA:AgBase.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0030315; C:T-tubule; IEA:Ensembl.
DR   GO; GO:0014802; C:terminal cisterna; IDA:AgBase.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IEA:Ensembl.
DR   GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0015643; F:toxic substance binding; IDA:AgBase.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0006936; P:muscle contraction; IEA:Ensembl.
DR   GO; GO:0043931; P:ossification involved in bone maturation; IEA:Ensembl.
DR   GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IMP:AgBase.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0048741; P:skeletal muscle fiber development; IEA:Ensembl.
DR   GO; GO:0043588; P:skin development; IEA:Ensembl.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR033215; RyR1.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   PANTHER; PTHR13715:SF97; PTHR13715:SF97; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 3.
DR   Pfam; PF00622; SPRY; 2.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 2.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 5.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001811};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4540   4560       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4815   4837       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4896   4919       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       98    153       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      160    205       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      211    265       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      271    334       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      336    387       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      582    798       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1354   1567       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     1865   1916       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5015 AA;  560341 MW;  D924EEBBD454D6A5 CRC64;
     MGDGGEGEDE VQFLRTDDEV VLQCSATVLK EQLKLCLAAE GFGNRLCFLE PTSNAQGLVP
     EVASCSRTYP RPQKGRVLGS VLTVCPSPTP QSSQGGGHRT LLYGHAILLR HAHSRMYLSC
     LTTSRSMTDK LAFDVGLQED ATGEACWWTM HPASKQRSEG EKVRVGDDLI LVSVSSERYL
     HLSTASGELQ VDASFMQTLW NMNPICSCCE EGYVTGGHVL RLFHGHMDEC LTISAADSDD
     QRRLVYYEGG AVCTHARSLW RLEPLRISWS GSHLRWGQPL RIRHVTTGRY LALTEDQGLV
     VVDACKAHTK ATSFCFRVSK EKLDTAPKRD VEGMGPPEIK YGESLCFVQH VASGLWLTYA
     APDPKALRLG VLKKKTDRHG DGRIKEISIV TDCEGREATS DRGKRVTAGL YNQFIKGLDS
     FSGKPRGSGP PAGPALPIEA VILSLQDLIG YFEPPSEELQ HEEKQSKLRS LRNRQSLFQE
     EGMLSLVLNC IDRLNVYTTA AHFAEYAGEE AAESWKEIVN LLYELLASLI RGNRANCALF
     STNLDWVVSK LDRLEASSGI LEVLYCVLIE SPEVLNIIQE NHIKSIISLL DKHGRNHKVL
     DVLCSLCVCN GVAVRSNQDL ITENLLPGRE LLLQTNLINY VTSIRPNIFV GRAEGSTQYG
     KWYFEVMVDE VVPFLTAQAT HLRVGWALTE GYSPYPGGGE GWGGNGVGDD LYSYGFDGLH
     LWTGHVARPV TSPGQHLLAP EDVVSCCLDL SVPSISFRIN GCPVQGVFEA FNLDGLFFPV
     VSFSAGVKVR FLLGGRHGEF KFLPPPGYAP CHEAVLPRER LRLEPIKEYR REGPRGPHLV
     GPSRCLSHTD FVPCPVDTVQ IVLPPHLERI REKLAENIHE LWALTRIEQG WTYGPVRDDN
     KRLHPCLVNF HSLPEPERNY NLQMSGETLK TLLALGCHVG MADEKAEDNL KKTKLPKTYM
     MSNGYKPAPL DLSHVRLTPA QTTLVDRLAE NGHNVWARDR VAQGWSYSAV QDIPARRNPR
     LVPYRLLDEA TKRSNRDSLC QAVRTLLGYG YNIEPPDQEP SQVENQSRWD RVRIFRAEKS
     YTVQSGRWYF EFEAVTTGEM RVGWARPELR PDVELGADEL AYIFNGHRGA LGGRTTREVA
     KVGLRGRVRE SLLALAAAKR VFSAQGTDTT SSREAELKYA QPGGGISQTC CPAERSQTQE
     GTSYRSPFTG NSPRPALAPL RASFVQRVSG QFSHRLRTMG PPAGSMLSFH LQVARMDGTV
     DTPPCLRLAH RTWGSQNSLV EMLFLRLSLP VQFHQHFRCT AGATPLAPPG LQPPAEDEAR
     AAEPDPDYEN LRRSAGGWGE AEGGKEGTAK EGTPGGTPQP GVEAQPVRAE NEKDATTEKN
     KKRGFLFKAK KAAMMTQPPA TPALPRLPHD VVPADNRDDP EIILNTTTYY YSVRVFAGQE
     PSCVWVGWVT PDYHQHDMNF DLSKVRAVTV TMGDEQGNVH SSLKCSNCYM VWGGDFVSPG
     QQGRISHTDL VIGCLVDLAT GLMTFTANGK ESNTFFQVEP NTKLFPAVFV LPTHQNVIQF
     ELGKQKNIMP LSAAMFLSER KNPAPQCPPR LEVQMLMPVS WSRMPNHFLQ VETRRAGERL
     GWAVQCQDPL TMMALHIPEE NRCMDILELS ERLDLQRFHS HTLRLYRAVC ALGNNRVAHA
     LCSHVDQAQL LHALEDAHLP GPLRAGYYDL LISIHLESAC RSRRSMLSEY IVPLTPETRA
     ITLFPPGRKG GNARRHGLPG VGVTTSLRPP HHFSPPCFVA ALPAAGVAEA PARLSPAIPL
     EALRDKALRM LGEAVRDGGQ HARDPVGGSV EFQFVPVLKL VSTLLVMGIF GDEDVKQILK
     MIEPEVFTEE EEEEEEEEEE EEEEEEDEEE KEEDEEEEEK EDAEKEEEEA PEGEKEDLEE
     GLLQMKLPES VKLQMCNLLE YFCDQELQHR VESLAAFAER YVDKLQANQR SRYALLMRAF
     TMSAAETARR TREFRSPPQE QINMLLHFKD DADEEDCPLP EDIRQDLQDF HQDLLAHCGI
     QLEGEEEEPE EETSLSSRLR SLLETVRLVK KKEEKPEEEL PAEEKKPQSL QELVSHMVVR
     WAQEDYVQSP ELVRAMFSLL HRQYDGLGEL LRALPRAYTI SPSSVEDTMS LLECLGQIRS
     LLIVQMGPQE ENLMIQSIGN IMNNKVFYQH PNLMRALGMH ETVMEVMVNV LGGGETKEIR
     FPKMVTSCCR FLCYFCRISR QNQRSMFDHL SYLLENSGIG LGMQGSTPLD VAAASVIDNN
     ELALALQEQD LEKVVSYLAG CGLQSCPMLL AKGYPDIGWN PCGGERYLDF LRFAVFVNGE
     SVEENANVVV RLLIRKPECF GPALRGEGGS GLLAAIEEAI RISEDPARDG PGVRRDRRRE
     HFGEEPPEEN RVHLGHAIMS FYAALIDLLG RCAPEMHLIQ AGKGEALRIR AILRSLVPLD
     DLVGIISLPL QIPTLGKDGA LVQPKMSASF VPDHKASMVL FLDRVYGIEN QDFLLHVLDV
     GFLPDMRAAA SLDTACGPAA TAGLLFVLGL CCFHNPAPQQ PQKKQKPRNT RALLEGLFLY
     TTLSNKYEGG VGRAAWEVRN DCLPLAGRGR PAFDSITITR PLLMFPQLCV PPPIPTQLLT
     NHYERCWKYY CLPTGWANFG VTSEEELHLT RKLFWGIFDS LAHKKYDQEL YRMAMPCLCA
     IAGALPPDYV DASYSSKAEK KATVDAEGNF DPRPVETLNV IIPEKLDSFI NKFAEYTHEK
     WAFDKIQNNW SYGENVDEEL KTHPMLRPYK TFSEKESSIW GVPHPQTLPS SKGAAEVLQN
     ERLRGHRHGA GRPRGRRGAG WTAGARAGPG WGPVGGAGPD RGGRGVAGGR RRGQGRLRGR
     AIEGRGLRRR RGQEDLGAGL QSAVGTKEEP GPGRRQKPLW QSSRPRSTGL KDMELDTSSI
     EKRFAFGFLQ QLLRWMDISQ EFIAHLEAVV SSGRVEKSPH EQEIKFFAKI LLPLINQYFT
     NHCLYFLSTP AKVLGSGGHA SNKEKEMITS LFCKLAALVR HRVSLFGTDA PAVVNCLHIL
     ARSLDARTVM KSGPEIVKAG LRSFFESASE DIEKMVENLR LGKVSQARTQ VKGVGQNLTY
     TTVALLPVLT TLFQHIAQHQ FGDDVILDDV QVSCYRTLCS IYSLGTTKNT YVEKLRPALG
     ECLARLAAAM PVAFLEPQLN EYNACSVYTT KSPRERAILG LPNSVEEMCP DIPVLDRLMA
     DIGGLAESGA RYTEMPHVIE ITLPMLCSYL PRWWERGPEA PPPALPAGAP PPCTAVTSDH
     LNSLLGNILR IIVNNLGIDE ATWMKRLAVF AQPIVSRARP ELLHSHFIPT IGRLRKRAGK
     VVAEEEQLRL EAKAEAEEGE LLVRDEFSVL CRDLYALYPL LIRYVDNNRA HWLTELNANA
     EELFRMVGEI FIYWSKSHNF REEPNFVVQN EINNMSFLTA DSKSKMAKAG DAQSGGSDQE
     RTKKKRRGDR YSVQTSLIVA TLKKMLPIGL NMCAPTDQDL IMLAKTRYAL KDTDEEVREF
     LQNNLHLQGK VEGSPSLRWQ MALYRGLPGR EEDADDPEKI VRRVQEVSAV LYHLEQTEHP
     YKSKKAVWHK LLSKQRRRAV VACFRMTPLY NLPTHRACNM FLESYKAAWI LTEDHSFEDR
     MIDDLSKAGE QEEEEEEVEE KKPDPLHQLV LHFSRTALTE KSKLDEDYLY MAYADIMAKS
     CHLEEGGENG EAEEEEVEVS FEEKEMEKQR LLYQQSRLHT RGAAEMVLQM ISACKGETGA
     MVSSTLKLGI SILNGGNAEV QQKMLDYLKD KKEVGFFQSI QALMQTCSVL DLNAFERQNK
     AEGLGMVNED GTVINRQNGE KVMADDEFTQ DLFRFLQLLC EGHNNDFQNY LRTQTGNTTT
     INIIICTVDY LLRLQESISD FYWYYSGKDV IEEQGKRNFS KAMSVAKQVF NSLTEYIQGP
     CTGNQQSLAH SRLWDAVVGF LHVFAHMMMK LAQDSSQIEL LKELLDLQKD MVVMLLSLLE
     GNVVNGMIAR QMVDMLVESS SNVEMILKFF DMFLKLKDIV GSEAFQDYVT DPRGLISKKD
     FQKAMDSQKQ FTGPEIQFLL SCSEADENEM INFEEFANRF QEPARDIGFN VAVLLTNLSE
     HVPHDPRLRN FLELAESILE YFRPYLGRIE IMGASRRIER IYFEISETNR AQWEMPQVRA
     PVRTPLMQAH TRCREREPLL LTLPAAPGSP VYSAGTLESL HTPPPSPHAA CTQDMQTPAS
     AASPGPFTSR VCAGGGAFPA PRPDVTSPLR EGKTASQPVS DRRARLTLLL VSKSQKTGLL
     GTACGDSVFL DRGQRAPAQR VASDDGMREG SEPGTAGLTP AWPLPLSSAP HAVPAARPAG
     QGVQAPGGEA EKMELFGDGD EEVAGHEAGP GGAEGVVAVA DGGPFRPEGA GGLGDMGDTT
     PAEPPTPEGS PILKRKLGVD GEEEELVPEP EPEPEPEPEK ADEENGEKEE VPEAPPEPPK
     KAPPSPPAKK EEAGGAGMEF WGELEVQRVK FLNYLSRNFY TLRFLALFLA FAINFILLFY
     KVSDSPPGED DMEGSAAGDL AGAGSGGGSG WGSGAGEEAE GDEDENMVYY FLEESTGYME
     PALCELLHTL VAFLCIIGYN CLKVPLVIFK REKELARKLE FDGLYITEQP GDDDVKGQWD
     RLVLNTPSFP SNYWDKFVKR KVLDKHGDIF GRERIAELLG MDLASLEITA HNERKPDPPP
     GLLTWLMSID VKYQIWKFGV IFTDNSFLYL GWYMVMSLLG HYNNFFFAAH LLDIAMGVKT
     LRTILSSVTH NGKQLVMTVG LLAVVVYLYT VVAFNFFRKF YNKSEDEDEP DMKCDDMMTC
     YLFHMYVGVR AGGGIGDEIE DPAGDEYELY RVVFDITFFF FVIVILLAII QGLIIDAFGE
     LRDQQEQVKE DMETKCFICG IGSDYFDTTP HGFETHTLEE HNLANYMFFL MYLINKDETE
     HTGQESYVWK MYQERCWDFF PAGDCFRKQY EDQLS
//
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