ID   G1WC53_9BACT            Unreviewed;       691 AA.
AC   G1WC53;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   RecName: Full=prolyl oligopeptidase {ECO:0000256|ARBA:ARBA00011897};
DE            EC=3.4.21.26 {ECO:0000256|ARBA:ARBA00011897};
GN   ORFNames=HMPREF9431_01404 {ECO:0000313|EMBL:EGV31069.1};
OS   Segatella oulorum F0390.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC   Segatella.
OX   NCBI_TaxID=702438 {ECO:0000313|EMBL:EGV31069.1, ECO:0000313|Proteomes:UP000005141};
RN   [1] {ECO:0000313|EMBL:EGV31069.1, ECO:0000313|Proteomes:UP000005141}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0390 {ECO:0000313|EMBL:EGV31069.1,
RC   ECO:0000313|Proteomes:UP000005141};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Izard J., Ganesan A.,
RA   Baranova O.V., Blanton J.M., Tanner A.C., Dewhirst F.E., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA   Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA   Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Mehta T.,
RA   Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA   Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Prevotella oulorum F0390.";
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.;
CC         EC=3.4.21.26; Evidence={ECO:0000256|ARBA:ARBA00001070};
CC   -!- SIMILARITY: Belongs to the peptidase S9A family.
CC       {ECO:0000256|ARBA:ARBA00005228}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EGV31069.1}.
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DR   EMBL; ADGI01000048; EGV31069.1; -; Genomic_DNA.
DR   AlphaFoldDB; G1WC53; -.
DR   PATRIC; fig|702438.4.peg.1451; -.
DR   eggNOG; COG1505; Bacteria.
DR   HOGENOM; CLU_011290_1_1_10; -.
DR   Proteomes; UP000005141; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.130.10.120; Prolyl oligopeptidase, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002471; Pept_S9_AS.
DR   InterPro; IPR023302; Pept_S9A_N.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002470; Peptidase_S9A.
DR   PANTHER; PTHR42881; PROLYL ENDOPEPTIDASE; 1.
DR   PANTHER; PTHR42881:SF2; PROLYL ENDOPEPTIDASE; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   Pfam; PF02897; Peptidase_S9_N; 1.
DR   PRINTS; PR00862; PROLIGOPTASE.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
DR   PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005141}.
FT   DOMAIN          25..417
FT                   /note="Peptidase S9A N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02897"
FT   DOMAIN          475..690
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
SQ   SEQUENCE   691 AA;  77911 MW;  A27CED97EEACE48F CRC64;
     MLSAMTLATM SAQAQSFHYP KAPQSDVKDR YFDVEIADPF RPLEDDNSAE TQQWVAAENK
     LTRSYLDKLP QRERLMKRMK TLVNYEKIGT PFHVHGTWYV YKNNGLQNQS VLYKMEHLGG
     KLIEVLDPNK LSADGTVALK GINFSHNGRY MAYIISRSGS DWQEIYVKDL QTGRDLSDHI
     EWAKFSGAAW KGDGFYYSAY DAPTKHAFSG KNEVHKVYYH RLGTPQKDDV LFYQNPAHPL
     RFYHVSVNKE ETLMYLIESG EGNGNNLFVR DLRQPDAQFI QMTNDMSCQY SPQENIGDSI
     YIFTNWGAPK NRLMVADLKN PGLSAWKEVI PEGESVLEDV TFTNGKLILS YNKDACTHAY
     WCDMQGKNRK EIVLPSGTAS FYGKRDLAEC FYSFSSFTTP GSIYQLDVNS GKASVYAAPK
     VAFDSKNFET KQVFFTSKDG TRVPMFLTFK KGLKRNGKNP VFLYGYGGFN IPLYPSFSAL
     RIPFLEQGGI YVQVNLRGGS EYGEAWHLAG TKMQKQNVFD DFIAAAEWLI AQQYTDKKHL
     AIVGGSNGGL LVGACMTQRP DLYAVCIPQV GVLDMLRYHR FTIGWNWAPD YGTSADSKEM
     FNYLRGYSPL HNIKKGVHYP ATLITTADHD DRVVPAHSFK FAATLQQAQG GTAPILIRID
     SKAGHGGGKP LSKQIEEQAD IYSFILQNMG K
//