ID G1WH48_9ACTN Unreviewed; 388 AA.
AC G1WH48;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=SIS domain-containing protein {ECO:0000259|PROSITE:PS51464};
GN ORFNames=HMPREF9452_00769 {ECO:0000313|EMBL:EGX67067.1};
OS Collinsella tanakaei YIT 12063.
OC Bacteria; Actinomycetota; Coriobacteriia; Coriobacteriales;
OC Coriobacteriaceae; Collinsella.
OX NCBI_TaxID=742742 {ECO:0000313|EMBL:EGX67067.1, ECO:0000313|Proteomes:UP000004830};
RN [1] {ECO:0000313|EMBL:EGX67067.1, ECO:0000313|Proteomes:UP000004830}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YIT 12063 {ECO:0000313|EMBL:EGX67067.1,
RC ECO:0000313|Proteomes:UP000004830};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Morotomi M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Mehta T.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Collinsella tanakaei YIT 12063.";
RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-galactosamine 6-phosphate + H2O = D-tagatopyranose 1-
CC phosphate + NH4(+); Xref=Rhea:RHEA:47680, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:28938, ChEBI:CHEBI:71674, ChEBI:CHEBI:138150;
CC Evidence={ECO:0000256|ARBA:ARBA00029292};
CC -!- SIMILARITY: Belongs to the SIS family. AgaS subfamily.
CC {ECO:0000256|ARBA:ARBA00007748}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGX67067.1}.
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DR EMBL; ADLS01000009; EGX67067.1; -; Genomic_DNA.
DR RefSeq; WP_009140804.1; NZ_JH126468.1.
DR AlphaFoldDB; G1WH48; -.
DR STRING; 742742.HMPREF9452_00769; -.
DR GeneID; 62758526; -.
DR PATRIC; fig|742742.3.peg.744; -.
DR eggNOG; COG2222; Bacteria.
DR HOGENOM; CLU_012520_0_0_11; -.
DR OrthoDB; 9779207at2; -.
DR Proteomes; UP000004830; Unassembled WGS sequence.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:InterPro.
DR CDD; cd05010; SIS_AgaS_like; 1.
DR CDD; cd05008; SIS_GlmS_GlmD_1; 1.
DR InterPro; IPR035466; GlmS/AgaS_SIS.
DR InterPro; IPR035464; SIS_AgaS.
DR InterPro; IPR001347; SIS_dom.
DR InterPro; IPR046348; SIS_dom_sf.
DR PANTHER; PTHR32502:SF3; D-GALACTOSAMINE-6-PHOSPHATE DEAMINASE AGAS-RELATED; 1.
DR PANTHER; PTHR32502; N-ACETYLGALACTOSAMINE PERMEASE II COMPONENT-RELATED; 1.
DR SUPFAM; SSF53697; SIS domain; 1.
DR PROSITE; PS51464; SIS; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000004830};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 42..201
FT /note="SIS"
FT /evidence="ECO:0000259|PROSITE:PS51464"
FT DOMAIN 221..368
FT /note="SIS"
FT /evidence="ECO:0000259|PROSITE:PS51464"
SQ SEQUENCE 388 AA; 42242 MW; 9B999F1D902C6402 CRC64;
MFEKDIESLK ALGADITTGE IKQQPELWLD TLNIYKDNKD AIDALLADAR AMGEGRLSVI
FTGAGTSDYV GDTCAPYLRH AGDTNLYDFK PIATTDIVSA PRDFLRAEDP TLLVSFARSG
NSPESLAAVE VARKFVKNIK FLNITCAPEG KLAVQSADDP DALTLLIPRA NDKGFAMTGS
YSCMTLLSTL IFDSADLATK EAWVKQAAEM GEEVVAREEE ISSMLAGDFN RVTYLGSGSF
VGLAQESQLK ILELAHGLVA TSWDSCMGYR HGPKSFVDDK TLVFVFMNND EYTRQYDLDI
LNEINGDEIA QKTVAIQQDL TPAFEGESFT FAGREALPEG YLALPFVMFA QVISLLNSVR
VGNTPDTPSP TGTVNRVVKG VTIHPFEA
//
