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Database: UniProt
Entry: G1WKX0_9ACTN
LinkDB: G1WKX0_9ACTN
Original site: G1WKX0_9ACTN 
ID   G1WKX0_9ACTN            Unreviewed;       613 AA.
AC   G1WKX0;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   05-JUL-2017, entry version 40.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|RuleBase:RU000577};
GN   ORFNames=HMPREF9452_01983 {ECO:0000313|EMBL:EGX68896.1};
OS   Collinsella tanakaei YIT 12063.
OC   Bacteria; Actinobacteria; Coriobacteriia; Coriobacteriales;
OC   Coriobacteriaceae; Collinsella.
OX   NCBI_TaxID=742742 {ECO:0000313|EMBL:EGX68896.1, ECO:0000313|Proteomes:UP000004830};
RN   [1] {ECO:0000313|EMBL:EGX68896.1, ECO:0000313|Proteomes:UP000004830}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YIT 12063 {ECO:0000313|EMBL:EGX68896.1,
RC   ECO:0000313|Proteomes:UP000004830};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Morotomi M., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A.,
RA   Alvarado L., Arachchi H.M., Berlin A., Brown A., Chapman S.B.,
RA   Chen Z., Dunbar C., Freedman E., Gearin G., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D., Howarth C., Larson L., Lui A.,
RA   MacDonald P.J.P., Mehta T., Montmayeur A., Murphy C., Neiman D.,
RA   Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Collinsella tanakaei YIT 12063.";
RL   Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|RuleBase:RU000577,
CC       ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC       {ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EGX68896.1}.
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DR   EMBL; ADLS01000028; EGX68896.1; -; Genomic_DNA.
DR   RefSeq; WP_009142007.1; NZ_JH126474.1.
DR   EnsemblBacteria; EGX68896; EGX68896; HMPREF9452_01983.
DR   PATRIC; fig|742742.3.peg.1966; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000004830; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000004830};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|RuleBase:RU004227,
KW   ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004830}.
FT   DOMAIN      279    407       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      517    586       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
SQ   SEQUENCE   613 AA;  67546 MW;  F4CE5F5F067E7451 CRC64;
     MESEAQILLD DAIAFCQRDG QSDRLVNMLS QSTPVELDDE SLYIEAPSRF AVAFLEKNRS
     VVEAYLEEIA FMPISLVVQA PAGSHTGAVR PTIPAAPAAA QDTPVMATTE VPRPHQTNAM
     PEAIAANAAG VDMPQMAAPH MAVEPVEKPI ENPFDLEAAF AKPRVTVEND AAGFATAPGP
     MSFAPAGEHG GVNVTNTMSR DQFNRMFAQM KGVETGQTVQ KKSIEPAGSG APMTDASDQP
     VANPIGSKFT FDNFVYGDEN KLAYHSAMRF AAFADEPGQY NSLFIYGGSG LGKTHLLLAI
     KNHLAANKPH IKVKYANSQA YIDDFINEIA RQKTEGRAIL REYHEANVLI IDDIQNIIGK
     QASIEYFFSL MDEFIRENKK VVIASDRAPK NLGMDERLTS RFNAGMLCLV SEPGFEMKYM
     ILKRYYENTI KGGDGLNGMN VDPSLLGAFQ TNDGTLTDEQ LRHMAEISGN NIRELESYCE
     RCASLSFERE QQGGELTTED IEKVANEYFD TARKIIRIDT VQKVVADFYH LQPEDLKGTR
     RTKEIAFARH VAVYLSNSLC EMTSSAIGAE FGGRDHSTVL NSLKVVESKI KEDRRICDDL
     QKLKNKIVLQ SQS
//
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