GenomeNet

Database: UniProt
Entry: G2DLF6_9NEIS
LinkDB: G2DLF6_9NEIS
Original site: G2DLF6_9NEIS 
ID   G2DLF6_9NEIS            Unreviewed;       540 AA.
AC   G2DLF6;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-SEP-2017, entry version 38.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=l11_12290 {ECO:0000313|EMBL:EGV37476.1};
OS   Neisseria weaveri LMG 5135.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales;
OC   Neisseriaceae; Neisseria.
OX   NCBI_TaxID=1051985 {ECO:0000313|EMBL:EGV37476.1, ECO:0000313|Proteomes:UP000004938};
RN   [1] {ECO:0000313|EMBL:EGV37476.1, ECO:0000313|Proteomes:UP000004938}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 5135 {ECO:0000313|EMBL:EGV37476.1};
RX   PubMed=22188430; DOI=10.1111/j.1574-6968.2011.02485.x;
RA   Yi H., Cho Y.J., Yoon S.H., Park S.C., Chun J.;
RT   "Comparative genomics of Neisseria weaveri clarifies the taxonomy of
RT   this species and identifies genetic determinants that may be
RT   associated with virulence.";
RL   FEMS Microbiol. Lett. 328:100-105(2012).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EGV37476.1}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AFWQ01000023; EGV37476.1; -; Genomic_DNA.
DR   RefSeq; WP_004283942.1; NZ_AFWQ01000023.1.
DR   EnsemblBacteria; EGV37476; EGV37476; l11_12290.
DR   PATRIC; fig|1051985.3.peg.1246; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000004938; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000004938};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004938}.
FT   DOMAIN      237    367       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      448    517       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     245    252       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   540 AA;  60408 MW;  1DECBDC872FF1BC7 CRC64;
     MTLAEFWPLC LRRLSDTLTQ QQFKNWIAPL TVGEENGIWV IYAKNQFACN MVKNQFANAI
     ESVKGELAAG HVPLVFKIGV GKVFEMAAES AAEKSSGGVH TRPEDGGGSV GIAKTVDPAS
     VPESKPESAS AKDKDQTEAA EVVRVVDQPL SGNKKTVQDI LAKHLNKLPP EIQNKNRPSE
     NKTASKPQAE AAEEKKEQRY QQTNLAPDYT FETLVEGKGN HLAAAAAKSI AEKPGQNYNP
     FFLYGSTGLG KTHLVQAIGN ELLKNKPNAK VRYMHSDDYI RSFMNAVRTN SYDVFKQQYK
     QYDLLIIDDI QFIKGKDRTM EEFFYLYNHF HNEKKQLILT CDVLPTKIED MDDRLKSRFS
     WGLTLELEPP ELEMRVAILQ KKAEAAGVNL NEDAAFFIAN LIRSNVRELE GAFNRVSASS
     RFLGKEIDID LARNSLQDIV ANSYKVITAD LIIDATAKYY RVKISDILGK KRTRNIARPR
     QVAMSLTKEL TNLSLPSIGD AFGGRDHTTI MHGIKAVAKL REEDPELAQD YEKLLIIIQN
//
DBGET integrated database retrieval system