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Database: UniProt
Entry: G2FWC7_9FIRM
LinkDB: G2FWC7_9FIRM
Original site: G2FWC7_9FIRM 
ID   G2FWC7_9FIRM            Unreviewed;       322 AA.
AC   G2FWC7;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   07-JUN-2017, entry version 35.
DE   SubName: Full=Bacterial dnaA family protein {ECO:0000313|EMBL:EGW38086.1};
GN   ORFNames=DOT_4030 {ECO:0000313|EMBL:EGW38086.1};
OS   Desulfosporosinus sp. OT.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Peptococcaceae;
OC   Desulfosporosinus.
OX   NCBI_TaxID=913865 {ECO:0000313|EMBL:EGW38086.1, ECO:0000313|Proteomes:UP000004928};
RN   [1] {ECO:0000313|EMBL:EGW38086.1, ECO:0000313|Proteomes:UP000004928}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OT {ECO:0000313|EMBL:EGW38086.1,
RC   ECO:0000313|Proteomes:UP000004928};
RX   PubMed=21994931; DOI=10.1128/JB.06018-11;
RA   Abicht H.K., Mancini S., Karnachuk O.V., Solioz M.;
RT   "Genome Sequence of Desulfosporosinus sp. OT, an Acidophilic Sulfate-
RT   Reducing Bacterium from Copper Mining Waste in Norilsk, Northern
RT   Siberia.";
RL   J. Bacteriol. 193:6104-6105(2011).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC       {ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EGW38086.1}.
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DR   EMBL; AGAF01000178; EGW38086.1; -; Genomic_DNA.
DR   RefSeq; WP_009621521.1; NZ_AGAF01000178.1.
DR   EnsemblBacteria; EGW38086; EGW38086; DOT_4030.
DR   PATRIC; fig|913865.3.peg.3716; -.
DR   OrthoDB; POG091H02FF; -.
DR   BioCyc; DSP913865:G10U7-235-MONOMER; -.
DR   Proteomes; UP000004928; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000004928};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|RuleBase:RU004227,
KW   ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004928}.
FT   DOMAIN       24    154       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      231    299       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
SQ   SEQUENCE   322 AA;  37737 MW;  2F4F26033335EC2A CRC64;
     MNWFLSEFNI RAWRLIRSYR LEAAPNVTLI YGPRGIGKST MLRSLYQHNR LNEEVIFTDA
     LSFSRQYAYA AQDNKLKLFR QRYRSTRLLL IDDLQFFEGK VKTIEELHYT YEYVIGNGGK
     MVISLEANLP QLEFLGERLG SRFLSGVVVP VNCPLEHEME RFLDEYIHQK HLFMDRLVVG
     VIARLTDNLA DAMRVVEQFI QFAELEEDEL SLQCFQVFWD KEEEKRKMVA DPINIINIVS
     QNTKVSVEEL VGPSRKTNVN EARQLAIYTI RTLCQISFPL IACYFNRKHS TMITSYQKIQ
     AKLASDQELY KIYEIILKSF KA
//
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