ID G2GKX9_9ACTN Unreviewed; 336 AA.
AC G2GKX9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=2-hydroxyacid family dehydrogenase {ECO:0000313|EMBL:EGX55829.1};
GN ORFNames=SZN_30864 {ECO:0000313|EMBL:EGX55829.1};
OS Streptomyces zinciresistens K42.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=700597 {ECO:0000313|EMBL:EGX55829.1, ECO:0000313|Proteomes:UP000004217};
RN [1] {ECO:0000313|EMBL:EGX55829.1, ECO:0000313|Proteomes:UP000004217}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K42 {ECO:0000313|EMBL:EGX55829.1,
RC ECO:0000313|Proteomes:UP000004217};
RA Lin Y., Hao X., Johnstone L., Miller S.J., Wei G., Rensing C.;
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGX55829.1}.
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DR EMBL; AGBF01000190; EGX55829.1; -; Genomic_DNA.
DR RefSeq; WP_007502511.1; NZ_AGBF01000190.1.
DR AlphaFoldDB; G2GKX9; -.
DR PATRIC; fig|700597.3.peg.6046; -.
DR OrthoDB; 4324715at2; -.
DR Proteomes; UP000004217; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:UniProt.
DR CDD; cd12167; 2-Hacid_dh_8; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10996:SF178; 2-HYDROXYACID DEHYDROGENASE YGL185C-RELATED; 1.
DR PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
DR PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000004217}.
FT DOMAIN 120..296
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 336 AA; 35538 MW; 94CC8DE8FCB07FE7 CRC64;
MTQRPHAVLA MSAANVPLVF PPRVLARLRE ALDLDPAAVA EDFTDPRLRD ALARAEVLVT
GWGCPRLDTA ALDAVPRLRA VLHSAGSVKG LVTPELWRRR ITVTSAAAAN AVPVAEYTLA
MILLTGKDLL AARDRLRAER SALPGWRLLP GTGNHGRRVG VIGASRTGRR VIELLRPFDL
VTALTDPYAD TADAAALGVP LLPLDDLLRT SDVVTVHAPQ TPATHHLLGA RELALMPDGA
VLINTARGPL VDHDALTAEL RTGRLSAVLD VTEPEPLPDD SPLYGLPNAF LTPHLAGSQG
NEAARLGLAV AEEAARLRAG AAPAHPVDPA VLEREA
//
