UniProt: G2GNW4

Database: UniProt
Entry: G2GNW4_9ACTN

LinkDB:  G2GNW4_9ACTN 
Original site:  G2GNW4_9ACTN

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Ontology (5)   
   GO (5)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (36)   
   InterPro (19)   
   Pfam (8)   
   PROSITE (4)   
   SMART (5)   
All databases (42)   

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ID   G2GNW4_9ACTN            Unreviewed;      1550 AA.
AC   G2GNW4;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 61.
DE   SubName: Full=Putative type-I PKS {ECO:0000313|EMBL:EGX54801.1};
DE   Flags: Fragment;
GN   ORFNames=SZN_36097 {ECO:0000313|EMBL:EGX54801.1};
OS   Streptomyces zinciresistens K42.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=700597 {ECO:0000313|EMBL:EGX54801.1, ECO:0000313|Proteomes:UP000004217};
RN   [1] {ECO:0000313|EMBL:EGX54801.1, ECO:0000313|Proteomes:UP000004217}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K42 {ECO:0000313|EMBL:EGX54801.1,
RC   ECO:0000313|Proteomes:UP000004217};
RA   Lin Y., Hao X., Johnstone L., Miller S.J., Wei G., Rensing C.;
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EGX54801.1}.
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DR   EMBL; AGBF01000322; EGX54801.1; -; Genomic_DNA.
DR   OrthoDB; 9778690at2; -.
DR   Proteomes; UP000004217; Unassembled WGS sequence.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR   CDD; cd00833; PKS; 1.
DR   Gene3D; 3.30.70.3290; -; 2.
DR   Gene3D; 3.40.47.10; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR042104; PKS_dehydratase_sf.
DR   InterPro; IPR020807; PKS_DH.
DR   InterPro; IPR049551; PKS_DH_C.
DR   InterPro; IPR049552; PKS_DH_N.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF21089; PKS_DH_N; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   Pfam; PF14765; PS-DH; 1.
DR   SMART; SM00826; PKS_DH; 1.
DR   SMART; SM00822; PKS_KR; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SMART; SM01294; PKS_PP_betabranch; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS00606; KS3_1; 1.
DR   PROSITE; PS52004; KS3_2; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW   Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004217};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          885..960
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          985..1411
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   REGION          961..983
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:EGX54801.1"
FT   NON_TER         1550
FT                   /evidence="ECO:0000313|EMBL:EGX54801.1"
SQ   SEQUENCE   1550 AA;  160307 MW;  10815790F16007FF CRC64;
     LAPIAPRSAT VPFYSTVTGG LLDTERLDAA YWVRNLRQTV EFEATTRALI ADGLSAFVEC
     SAHPVLAVGV EESGASTVVG SLRREDGGAQ RFVTSLAQAY VNGLPVDLAP LVADGHAVDL
     PTYAFQGTHY WLRPTAGRTD FNAAGLGAAQ HPLLGAVVRL ADTDGALLTG RLSLADHPWL
     ADHTVDGHAI LPGAAYVELA VRAGDEVGCG RLAELTLQAP LELVDGRPVA VQVAVGTADA
     DGSRPLTVHA RRDDSGDASW TCHATGTLAP ADAAEPSFGL TAWPPPGASA VPLDTFYDDV
     TAAGYGYGPA FQGLRAVWTA GDEVYAEVTS VEPEEAERFL LHPAALDAAL HAILVRTGDA
     GDTATLRLPF SWSGVEVYAT GTADLRVQLT RTGDDTVSVR LTDTDGTPVA RVESLALRAP
     ATDTLGTKGA ADLLHVVWEP IVGLPAPTDA ADIVFLDTGA PDLDTVATPD GPAPDVVALA
     LPDDATDVRG LVGSVLALVR RWLSDDRWST SRLAFVTRRD SLAHAAVRGF VRSAQTEHPG
     RFQLLETERD SEPSPDAVAA ALATGEPQLA LGPTGISTPR LAPVPADPDT TSTPIDTEGT
     VLVTGGTGTL GSLLARHLVT AHGVRHLLLL SRGGPDAPGA PELAADLAAH GADAHIVACD
     AADRDALAAV LADIDPAHPL TAVVHTAGAL ADTVVTSLTD DHVDQVLRPK SDAAQHLHDL
     TAHLGLSAFV FFSSAAGVLG TAGQANYAAA NAYLDALAVR RRQEGLPAVS LAWGYWEQAS
     GLTGHLDRGD VLRLARTGVA PMTTAQGLAL FDAGLRTPHP AVVPLVLDRA ALHDAARSET
     LSPLLRTYAP RPRRRTTTAA AARGTSAVSD LARALVGLTP EQREHTLTEL VRAQAGAVLG
     HDSAAAVDAG QPFRTLGFDS LAAVELRNRL NTATGLRLPT TAVFDHPTPD RLAAHIGTLL
     DDGPEARTQP SAPGGPGASR ASAVDEPIAI VGMACRLPGG VGSPEELWHL VADGVDAVSP
     LPTDRGWDMD ALLGATDGTG GTSYVREGGF LYDAADFDAG FFGISPREAL AMDPQQRLLL
     ETSWEALERA GIDPTSLNGT RTGVFTGVMY HDYASRLDRV PEEVGGYLAT GTSGSVASGR
     VAYTLGLEGP AVTVDTACSS SLVALHLAAQ ALRQGECTMA LAGGVTVLSS PSVFSEFSRQ
     QGLATDGRCK SFADAADGTG WAEGVGVLLV ERLSDAVRNG HRVLAVVRGS AVNQDGASNG
     LTAPNGPAQQ RVIRQALESA RLSPTDVDAV EAHGTGTRLG DPIEAQALLA TYGQGREEGA
     ALLLGSLKSN IGHAQAAAGV AGVIKMVMAM RHGVLPRTLH VDEPSSHVDW SAGDVSLLTE
     SREWPETGRP RRAGVSSFGV SGTNAHVILE AVEHTDAPAH STPAVGGGAT PWVLSAASED
     ALRATAERLL THLQSVTDAD QDLLSVAGAL LRSRARLEHR AVVVGHDREE LLAGLYAVAA
     GEPGVVSGVA GAGVRPVFVF PGQGAQWSRM GLELADAFPV FDKALGACAA
//

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