ID G2GYW6_9ENTR Unreviewed; 577 AA.
AC G2GYW6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Type 3 secretion system secretin {ECO:0000256|HAMAP-Rule:MF_02219};
DE Short=T3SS secretin {ECO:0000256|HAMAP-Rule:MF_02219};
DE Flags: Precursor;
GN Name=sctC {ECO:0000256|HAMAP-Rule:MF_02219};
GN ORFNames=Rin_00009760 {ECO:0000313|EMBL:EGY29061.1};
OS Candidatus Regiella insecticola 5.15.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; aphid secondary symbionts; Regiella.
OX NCBI_TaxID=1005043 {ECO:0000313|EMBL:EGY29061.1, ECO:0000313|Proteomes:UP000004116};
RN [1] {ECO:0000313|EMBL:EGY29061.1, ECO:0000313|Proteomes:UP000004116}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R5.15 {ECO:0000313|Proteomes:UP000004116};
RX PubMed=21948522; DOI=10.1101/gr.125351.111;
RA Hansen A.K., Vorburger C., Moran N.A.;
RT "Genomic basis of endosymbiont-conferred protection against an insect
RT parasitoid.";
RL Genome Res. 22:106-114(2012).
CC -!- FUNCTION: Component of the type III secretion system (T3SS), also
CC called injectisome, which is used to inject bacterial effector proteins
CC into eukaryotic host cells. Forms a ring-shaped multimeric structure
CC with an apparent central pore in the outer membrane.
CC {ECO:0000256|HAMAP-Rule:MF_02219}.
CC -!- SUBUNIT: The core secretion machinery of the T3SS is composed of
CC approximately 20 different proteins, including cytoplasmic components,
CC a base, an export apparatus and a needle. This subunit is part of the
CC base, which anchors the injectisome in the bacterial cell envelope.
CC Forms a stable homooligomeric complex. {ECO:0000256|HAMAP-
CC Rule:MF_02219}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane
CC {ECO:0000256|ARBA:ARBA00004442, ECO:0000256|HAMAP-Rule:MF_02219,
CC ECO:0000256|RuleBase:RU004004}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the bacterial secretin family. T3SS SctC
CC subfamily. {ECO:0000256|ARBA:ARBA00007032, ECO:0000256|HAMAP-
CC Rule:MF_02219}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGY29061.1}.
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DR EMBL; AGCA01000249; EGY29061.1; -; Genomic_DNA.
DR RefSeq; WP_006706655.1; NZ_AGCA01000249.1.
DR AlphaFoldDB; G2GYW6; -.
DR PATRIC; fig|1005043.3.peg.877; -.
DR OrthoDB; 9779724at2; -.
DR Proteomes; UP000004116; Unassembled WGS sequence.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030257; C:type III protein secretion system complex; IEA:UniProtKB-UniRule.
DR GO; GO:0030254; P:protein secretion by the type III secretion system; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.120; -; 2.
DR Gene3D; 3.55.50.30; -; 1.
DR HAMAP; MF_02219; Type_III_secretin; 1.
DR InterPro; IPR005644; NolW-like.
DR InterPro; IPR038591; NolW-like_sf.
DR InterPro; IPR004846; T2SS/T3SS_dom.
DR InterPro; IPR004845; T2SS_GspD_CS.
DR InterPro; IPR049034; T3S_SPI-1_N0.
DR InterPro; IPR003522; T3SS_OM_pore_YscC.
DR NCBIfam; TIGR02516; type_III_yscC; 1.
DR PANTHER; PTHR30332; PROBABLE GENERAL SECRETION PATHWAY PROTEIN D; 1.
DR PANTHER; PTHR30332:SF5; SPI-1 TYPE 3 SECRETION SYSTEM SECRETIN; 1.
DR Pfam; PF00263; Secretin; 1.
DR Pfam; PF03958; Secretin_N; 1.
DR Pfam; PF21304; T3S_SPI-1_N0; 1.
DR PRINTS; PR01337; TYPE3OMGPROT.
DR PROSITE; PS00875; T2SP_D; 1.
PE 3: Inferred from homology;
KW Cell outer membrane {ECO:0000256|HAMAP-Rule:MF_02219};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_02219};
KW Protein transport {ECO:0000256|HAMAP-Rule:MF_02219};
KW Reference proteome {ECO:0000313|Proteomes:UP000004116};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|HAMAP-Rule:MF_02219};
KW Translocation {ECO:0000256|ARBA:ARBA00023010, ECO:0000256|HAMAP-
KW Rule:MF_02219};
KW Transport {ECO:0000256|HAMAP-Rule:MF_02219, ECO:0000256|RuleBase:RU004004};
KW Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02219"
FT CHAIN 24..577
FT /note="Type 3 secretion system secretin"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02219"
FT /id="PRO_5026394456"
FT DOMAIN 38..106
FT /note="SPI-1 type 3 secretion system secretin N0"
FT /evidence="ECO:0000259|Pfam:PF21304"
FT DOMAIN 182..325
FT /note="NolW-like"
FT /evidence="ECO:0000259|Pfam:PF03958"
FT DOMAIN 381..537
FT /note="Type II/III secretion system secretin-like"
FT /evidence="ECO:0000259|Pfam:PF00263"
SQ SEQUENCE 577 AA; 63632 MW; 9EC0C0436B0A1C50 CRC64;
MKKILSCLLT SVLFLSLIPG SLAQSASSMA PQGEAQGYLA KKEGIQGVFD ALSSRLNKPV
VLSKLAARKQ VSGHFDFTAP QQVLTQLATQ LGLIWYHDGQ SIYVYDASEI RNTMISLHTS
SFSAVKNFLV QARLYDKRYP LRGDENSATF YVSGPPVYIE LITRTAKFLD NQNESVDNRE
KVAVIKLHNT FVDDRQYDYR GQTIRLPGMA KIIQNLLANQ QQPQQVEILP QEKSESGQYA
PAMPAFSEQR PAVLPYKAPM GLAESLKMRQ NTSVATPSVA ARKVRSDIAL QVVANPSTNS
LLVKGRAEHI AFVKQLIAQL DQPKRHIELS VWIIDLEKTA LDQLGVNFNG RININGKFGA
SFNGGGASTL DGSRFIASIM ALSQQNKANI VSRPIVLTQE NIPAIFDNNC AFYSEVKGDR
VATLESVTYG TSVSVLPRFA EQSQIEMMLN IEDGNEIAQS DNEIKTSLPK VGRTKISTVA
RVPKGKSLLI GGYTRDSSNN TEAKIPGLGS LPWIGGLFRY RQGASANTVR VFLIQPREIE
GPLSRDASDI AGEMVKDLNA EPLQDWMRNY MDSQKWT
//
