ID G2HFY4_PANTR Unreviewed; 471 AA.
AC G2HFY4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Dihydrothymine dehydrogenase {ECO:0000256|ARBA:ARBA00032722};
DE AltName: Full=Dihydrouracil dehydrogenase {ECO:0000256|ARBA:ARBA00030119};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:BAK62642.1};
RN [1] {ECO:0000313|EMBL:BAK62642.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Testis {ECO:0000313|EMBL:BAK62642.1};
RX PubMed=21484476; DOI=10.1007/s10142-011-0220-9;
RA Kim R.N., Kim D.W., Choi S.H., Chae S.H., Nam S.H., Kim D.W., Kim A.,
RA Kang A., Park K.H., Lee Y.S., Hirai M., Suzuki Y., Sugano S., Hashimoto K.,
RA Kim D.S., Park H.S.;
RT "Major chimpanzee-specific structural changes in sperm development-
RT associated genes.";
RL Funct. Integr. Genomics 11:507-517(2011).
CC -!- SIMILARITY: Belongs to the dihydropyrimidine dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00010804}.
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DR EMBL; AK305648; BAK62642.1; -; mRNA.
DR AlphaFoldDB; G2HFY4; -.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR PANTHER; PTHR43073; DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]; 1.
DR PANTHER; PTHR43073:SF2; DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]; 1.
DR Pfam; PF07992; Pyr_redox_2; 1.
DR PRINTS; PR00419; ADXRDTASE.
DR SUPFAM; SSF51395; FMN-linked oxidoreductases; 1.
DR SUPFAM; SSF51971; Nucleotide-binding domain; 2.
PE 2: Evidence at transcript level;
FT DOMAIN 24..329
FT /note="FAD/NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF07992"
SQ SEQUENCE 471 AA; 51360 MW; 62CA400CE7690D08 CRC64;
MSIPQIRNPS LPPPEKMSEA YSAKIALFGA GPASISCASF LARLGYSDIT IFEKQEYVGG
LSTSEIPQFR LPYDVVNFEI ELMKDLGVKI ICGKSLSVNE MTLSTLKEKG YKAAFIGIGL
PEPNKDAIFQ GLTQDQGFYT SKDFLPLVAK GSKAGMCACH SPLPSIRGVV IVLGAGDSAF
DCATSALRCG ARRVFIVFRK GFVNIRAVPE EMELAKEEKC EFLPFLSPRK VIVKGGRIVA
MQFVRTEQDE TGKWNEDEDQ MVHLKADVVI SAFGSVLSDP KVKEALSPIK FNRWGLPEVD
PETMQTSEAW VFAGGDVVGL ANTTVESVND GKQASWYIHK YVQSQYGASV SAKPELPLFY
TPIDLVDISV EMAGLKFINP FGLASATPAT STSMIRRAFE AGWGFALTKT LSLDKDIVTN
VSPRIIRGTT SGPMYGPGQS SFLNIELISE KTAAYWCQSV TELKADFPDN E
//
