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Database: UniProt
Entry: G2HGI8_PANTR
LinkDB: G2HGI8_PANTR
Original site: G2HGI8_PANTR 
ID   G2HGI8_PANTR            Unreviewed;       573 AA.
AC   G2HGI8;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   22-FEB-2023, entry version 41.
DE   RecName: Full=Methyl-CpG-binding domain protein 4 {ECO:0000256|PIRNR:PIRNR038005};
DE            EC=3.2.2.- {ECO:0000256|PIRNR:PIRNR038005};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|EMBL:BAK62846.1};
RN   [1] {ECO:0000313|EMBL:BAK62846.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Testis {ECO:0000313|EMBL:BAK62846.1};
RX   PubMed=21484476; DOI=10.1007/s10142-011-0220-9;
RA   Kim R.N., Kim D.W., Choi S.H., Chae S.H., Nam S.H., Kim D.W., Kim A.,
RA   Kang A., Park K.H., Lee Y.S., Hirai M., Suzuki Y., Sugano S., Hashimoto K.,
RA   Kim D.S., Park H.S.;
RT   "Major chimpanzee-specific structural changes in sperm development-
RT   associated genes.";
RL   Funct. Integr. Genomics 11:507-517(2011).
CC   -!- FUNCTION: Mismatch-specific DNA N-glycosylase involved in DNA repair.
CC       Has thymine glycosylase activity and is specific for G:T mismatches
CC       within methylated and unmethylated CpG sites. Can also remove uracil or
CC       5-fluorouracil in G:U mismatches. Has no lyase activity. Was first
CC       identified as methyl-CpG-binding protein.
CC       {ECO:0000256|PIRNR:PIRNR038005}.
CC   -!- SUBUNIT: Interacts with MLH1. {ECO:0000256|PIRNR:PIRNR038005}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PIRNR:PIRNR038005}.
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DR   EMBL; AK305852; BAK62846.1; -; mRNA.
DR   RefSeq; NP_001267403.1; NM_001280474.1.
DR   AlphaFoldDB; G2HGI8; -.
DR   GeneID; 738526; -.
DR   KEGG; ptr:738526; -.
DR   CTD; 8930; -.
DR   OrthoDB; 1451962at2759; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008263; F:pyrimidine-specific mismatch base pair DNA N-glycosylase activity; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   CDD; cd01396; MeCP2_MBD; 1.
DR   InterPro; IPR016177; DNA-bd_dom_sf.
DR   InterPro; IPR011257; DNA_glycosylase.
DR   InterPro; IPR017352; MBD4.
DR   InterPro; IPR045138; MeCP2/MBD4.
DR   InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR   PANTHER; PTHR15074:SF7; METHYL-CPG-BINDING DOMAIN PROTEIN 4; 1.
DR   PANTHER; PTHR15074; METHYL-CPG-BINDING PROTEIN; 1.
DR   Pfam; PF01429; MBD; 1.
DR   PIRSF; PIRSF038005; Methyl_CpG_bd_MBD4; 1.
DR   SMART; SM00391; MBD; 1.
DR   SUPFAM; SSF54171; DNA-binding domain; 1.
DR   SUPFAM; SSF48150; DNA-glycosylase; 1.
DR   PROSITE; PS50982; MBD; 1.
PE   2: Evidence at transcript level;
KW   DNA damage {ECO:0000256|PIRNR:PIRNR038005};
KW   DNA repair {ECO:0000256|PIRNR:PIRNR038005};
KW   DNA-binding {ECO:0000256|PIRNR:PIRNR038005};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR038005};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR038005};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT   DOMAIN          76..148
FT                   /note="MBD"
FT                   /evidence="ECO:0000259|PROSITE:PS50982"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   573 AA;  65156 MW;  76774A5F7D0CF931 CRC64;
     MGTTGLESLS LGDRGAAPTV TSSERLVPDP PNDLRKEDVA MELERVGEDE EQMMIKRSSE
     CNPLLQEPIA SAQFGATAGT ECRKSVPCGW ERVVKQRLFG KTAGRFDVYF ISPQGLKFRS
     KSSLANYLHK NGETSLKPED FDFTVLSKRG IKSRCKDCSM AALTSHLQNQ SNNSNWNLRT
     RSKCKKDVFM PPSSSSELQE GRGLSNFTST HLLLKEDEGV DDVNFRKVRK PKGKVTILKG
     IPIKKTKKGC RKSCSGFVRS DSKRESVCNK ADAESEPVAQ KSQLDRTVCI SDAGACGETL
     SVTSEENSLV KKKERSLSSG SNFCSEQKTS GIINKFCSAK DSEHNEKYED TFLESEEIGT
     KVEVVERKEH LHTDILKRGS EMDNNCSPTR KDFTDTIPRT QIQRRKTSLY FSSKYNKEAL
     SPPRRKAFKK WTPPRSPFNL VQETLFHDPW KLLIATIFLN RTSGKMAIPV LWKFLEKYPS
     AEVARTADWR DVSELLKPLG LYDLRAKTIV KFSDEYLTKQ WKYPIELHGI GKYGNDSYRI
     FCVNEWKQVH PEDHKLNKYH DWLWENHEKL SLS
//
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