ID G2HGI8_PANTR Unreviewed; 573 AA.
AC G2HGI8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 22-FEB-2023, entry version 41.
DE RecName: Full=Methyl-CpG-binding domain protein 4 {ECO:0000256|PIRNR:PIRNR038005};
DE EC=3.2.2.- {ECO:0000256|PIRNR:PIRNR038005};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:BAK62846.1};
RN [1] {ECO:0000313|EMBL:BAK62846.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Testis {ECO:0000313|EMBL:BAK62846.1};
RX PubMed=21484476; DOI=10.1007/s10142-011-0220-9;
RA Kim R.N., Kim D.W., Choi S.H., Chae S.H., Nam S.H., Kim D.W., Kim A.,
RA Kang A., Park K.H., Lee Y.S., Hirai M., Suzuki Y., Sugano S., Hashimoto K.,
RA Kim D.S., Park H.S.;
RT "Major chimpanzee-specific structural changes in sperm development-
RT associated genes.";
RL Funct. Integr. Genomics 11:507-517(2011).
CC -!- FUNCTION: Mismatch-specific DNA N-glycosylase involved in DNA repair.
CC Has thymine glycosylase activity and is specific for G:T mismatches
CC within methylated and unmethylated CpG sites. Can also remove uracil or
CC 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first
CC identified as methyl-CpG-binding protein.
CC {ECO:0000256|PIRNR:PIRNR038005}.
CC -!- SUBUNIT: Interacts with MLH1. {ECO:0000256|PIRNR:PIRNR038005}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR038005}.
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DR EMBL; AK305852; BAK62846.1; -; mRNA.
DR RefSeq; NP_001267403.1; NM_001280474.1.
DR AlphaFoldDB; G2HGI8; -.
DR GeneID; 738526; -.
DR KEGG; ptr:738526; -.
DR CTD; 8930; -.
DR OrthoDB; 1451962at2759; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008263; F:pyrimidine-specific mismatch base pair DNA N-glycosylase activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd01396; MeCP2_MBD; 1.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR011257; DNA_glycosylase.
DR InterPro; IPR017352; MBD4.
DR InterPro; IPR045138; MeCP2/MBD4.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR PANTHER; PTHR15074:SF7; METHYL-CPG-BINDING DOMAIN PROTEIN 4; 1.
DR PANTHER; PTHR15074; METHYL-CPG-BINDING PROTEIN; 1.
DR Pfam; PF01429; MBD; 1.
DR PIRSF; PIRSF038005; Methyl_CpG_bd_MBD4; 1.
DR SMART; SM00391; MBD; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF48150; DNA-glycosylase; 1.
DR PROSITE; PS50982; MBD; 1.
PE 2: Evidence at transcript level;
KW DNA damage {ECO:0000256|PIRNR:PIRNR038005};
KW DNA repair {ECO:0000256|PIRNR:PIRNR038005};
KW DNA-binding {ECO:0000256|PIRNR:PIRNR038005};
KW Hydrolase {ECO:0000256|PIRNR:PIRNR038005};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR038005};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 76..148
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 573 AA; 65156 MW; 76774A5F7D0CF931 CRC64;
MGTTGLESLS LGDRGAAPTV TSSERLVPDP PNDLRKEDVA MELERVGEDE EQMMIKRSSE
CNPLLQEPIA SAQFGATAGT ECRKSVPCGW ERVVKQRLFG KTAGRFDVYF ISPQGLKFRS
KSSLANYLHK NGETSLKPED FDFTVLSKRG IKSRCKDCSM AALTSHLQNQ SNNSNWNLRT
RSKCKKDVFM PPSSSSELQE GRGLSNFTST HLLLKEDEGV DDVNFRKVRK PKGKVTILKG
IPIKKTKKGC RKSCSGFVRS DSKRESVCNK ADAESEPVAQ KSQLDRTVCI SDAGACGETL
SVTSEENSLV KKKERSLSSG SNFCSEQKTS GIINKFCSAK DSEHNEKYED TFLESEEIGT
KVEVVERKEH LHTDILKRGS EMDNNCSPTR KDFTDTIPRT QIQRRKTSLY FSSKYNKEAL
SPPRRKAFKK WTPPRSPFNL VQETLFHDPW KLLIATIFLN RTSGKMAIPV LWKFLEKYPS
AEVARTADWR DVSELLKPLG LYDLRAKTIV KFSDEYLTKQ WKYPIELHGI GKYGNDSYRI
FCVNEWKQVH PEDHKLNKYH DWLWENHEKL SLS
//