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Database: UniProt
Entry: G2LFW8_CHLTF
LinkDB: G2LFW8_CHLTF
Original site: G2LFW8_CHLTF 
ID   G2LFW8_CHLTF            Unreviewed;       464 AA.
AC   G2LFW8;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   25-OCT-2017, entry version 46.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000256|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000256|HAMAP-Rule:MF_00378};
GN   OrderedLocusNames=Cabther_A1006 {ECO:0000313|EMBL:AEP11762.1};
OS   Chloracidobacterium thermophilum (strain B).
OC   Bacteria; Acidobacteria; Blastocatellia; Chloracidobacterium.
OX   NCBI_TaxID=981222 {ECO:0000313|EMBL:AEP11762.1, ECO:0000313|Proteomes:UP000006791};
RN   [1] {ECO:0000313|EMBL:AEP11762.1, ECO:0000313|Proteomes:UP000006791}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B {ECO:0000313|EMBL:AEP11762.1,
RC   ECO:0000313|Proteomes:UP000006791};
RX   PubMed=21951563; DOI=10.1111/j.1462-2920.2011.02592.x;
RA   Garcia Costas A.M., Liu Z., Tomsho L.P., Schuster S.C., Ward D.M.,
RA   Bryant D.A.;
RT   "Complete genome of Candidatus Chloracidobacterium thermophilum, a
RT   chlorophyll-based photoheterotroph belonging to the phylum
RT   Acidobacteria.";
RL   Environ. Microbiol. 14:177-190(2012).
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large
CC       acid-insoluble oligonucleotides, which are then degraded further
CC       into small acid-soluble oligonucleotides. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|SAAS:SAAS00723532}.
CC   -!- CATALYTIC ACTIVITY: Exonucleolytic cleavage in either 5'- to
CC       3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.
CC       {ECO:0000256|HAMAP-Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723505}.
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000256|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
CC       ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723552}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723548}.
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DR   EMBL; CP002514; AEP11762.1; -; Genomic_DNA.
DR   RefSeq; WP_014099500.1; NC_016024.1.
DR   STRING; 981222.Cabther_A1006; -.
DR   EnsemblBacteria; AEP11762; AEP11762; Cabther_A1006.
DR   KEGG; ctm:Cabther_A1006; -.
DR   eggNOG; ENOG4105DVS; Bacteria.
DR   eggNOG; COG1570; LUCA.
DR   KO; K03601; -.
DR   OMA; NARRRWP; -.
DR   Proteomes; UP000006791; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006791};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|SAAS:SAAS00723549};
KW   Exonuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723511};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723558,
KW   ECO:0000313|EMBL:AEP11762.1};
KW   Nuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723518};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006791}.
FT   DOMAIN       11    103       tRNA_anti_2. {ECO:0000259|Pfam:PF13742}.
FT   DOMAIN      127    443       Exonuc_VII_L. {ECO:0000259|Pfam:PF02601}.
SQ   SEQUENCE   464 AA;  51090 MW;  9E90223CC5575161 CRC64;
     MWEAPEAPPR LTVSALTAQI RRQLEGEFRE VIVEGELSNF VAHTSGHWYF TLKDAQSQIR
     CACWKGTNYR IRFRPRNGQQ VVCRGKVTVY APKGEYQLTV EAMAPVGVGE QQLAFEQLKA
     KLAAEGLLAP ERKRPLPLVP RRIGIVTSPT GAAIQDILNV LRRRNDGVSV LLYPAQVEGA
     EAAASVAAGI RWFSENPDPD FPVDVLIVGR GGGSAEALWA FNTEEVARAI ADSTIPVISA
     VGHEIDFTIA DFVADLRAPT PSAAAEMVTA RRADLLAEVG SMASALTKVM HIRLLRERQA
     LETLARHPVF DDTQARLRDA LQTCDELTLA VQSAVQNRLR FAGWRLERAG NRLRHYPWRP
     YLQLHEQRVS ELTAKLIAGV QAQAAVAQHR LAQALTRLNT LSPLRVLARG YALVQHPDGR
     LIRTTEDAVP GQDIVIRLSD GRLLGRVAQV LPEPEAKPDP PPHS
//
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