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Database: UniProt
Entry: G2MM54_9ARCH
LinkDB: G2MM54_9ARCH
Original site: G2MM54_9ARCH 
ID   G2MM54_9ARCH            Unreviewed;       324 AA.
AC   G2MM54;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   31-JAN-2018, entry version 36.
DE   RecName: Full=Transcription initiation factor IIB {ECO:0000256|HAMAP-Rule:MF_00383};
DE            Short=TFIIB {ECO:0000256|HAMAP-Rule:MF_00383};
GN   Name=tfb {ECO:0000256|HAMAP-Rule:MF_00383};
GN   ORFNames=Halar_2447 {ECO:0000313|EMBL:AEN06101.1};
OS   halophilic archaeon DL31.
OC   Archaea.
OX   NCBI_TaxID=756883 {ECO:0000313|EMBL:AEN06101.1, ECO:0000313|Proteomes:UP000010096};
RN   [1] {ECO:0000313|EMBL:AEN06101.1, ECO:0000313|Proteomes:UP000010096}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DL31 {ECO:0000313|EMBL:AEN06101.1,
RC   ECO:0000313|Proteomes:UP000010096};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Mikhailova N., Teshima H., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I.,
RA   Dyall-Smith M., Cavicchioli R., Woyke T.;
RT   "Complete sequence of chromosome of halophilic archaeon DL31.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stabilizes TBP binding to an archaeal box-A promoter.
CC       Also responsible for recruiting RNA polymerase II to the pre-
CC       initiation complex (DNA-TBP-TFIIB). {ECO:0000256|HAMAP-
CC       Rule:MF_00383}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00383};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|HAMAP-
CC       Rule:MF_00383};
CC   -!- SIMILARITY: Belongs to the TFIIB family. {ECO:0000256|HAMAP-
CC       Rule:MF_00383}.
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DR   EMBL; CP002988; AEN06101.1; -; Genomic_DNA.
DR   RefSeq; WP_014051873.1; NC_015954.1.
DR   STRING; 756883.Halar_2447; -.
DR   EnsemblBacteria; AEN06101; AEN06101; Halar_2447.
DR   GeneID; 11095814; -.
DR   KEGG; hah:Halar_2447; -.
DR   eggNOG; arCOG01981; Archaea.
DR   eggNOG; COG1405; LUCA.
DR   KO; K03124; -.
DR   OrthoDB; POG093Z07LX; -.
DR   Proteomes; UP000010096; Chromosome.
DR   GO; GO:0003700; F:DNA binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0070897; P:DNA-templated transcriptional preinitiation complex assembly; IEA:InterPro.
DR   Gene3D; 1.10.472.10; -; 2.
DR   HAMAP; MF_00383; TF2B_arch; 1.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR000812; TFIIB.
DR   InterPro; IPR023484; TFIIB_arc.
DR   InterPro; IPR023486; TFIIB_CS.
DR   InterPro; IPR013150; TFIIB_cyclin.
DR   InterPro; IPR013137; Znf_TFIIB.
DR   PANTHER; PTHR11618; PTHR11618; 1.
DR   Pfam; PF08271; TF_Zn_Ribbon; 1.
DR   Pfam; PF00382; TFIIB; 2.
DR   PRINTS; PR00685; TIFACTORIIB.
DR   SMART; SM00385; CYCLIN; 2.
DR   SUPFAM; SSF47954; SSF47954; 2.
DR   PROSITE; PS00782; TFIIB; 2.
DR   PROSITE; PS51134; ZF_TFIIB; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000010096};
KW   Initiation factor {ECO:0000313|EMBL:AEN06101.1};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00383, ECO:0000256|PROSITE-
KW   ProRule:PRU00469};
KW   Protein biosynthesis {ECO:0000313|EMBL:AEN06101.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010096};
KW   Repeat {ECO:0000256|HAMAP-Rule:MF_00383};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_00383};
KW   Transcription regulation {ECO:0000256|HAMAP-Rule:MF_00383};
KW   Zinc {ECO:0000256|HAMAP-Rule:MF_00383, ECO:0000256|PROSITE-
KW   ProRule:PRU00469};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00469}.
FT   DOMAIN       23     54       TFIIB-type. {ECO:0000259|PROSITE:
FT                                PS51134}.
FT   REPEAT      140    223       1. {ECO:0000256|HAMAP-Rule:MF_00383}.
FT   REPEAT      234    315       2. {ECO:0000256|HAMAP-Rule:MF_00383}.
FT   ZN_FING      23     54       TFIIB-type. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00469}.
FT   METAL        28     28       Zinc. {ECO:0000256|HAMAP-Rule:MF_00383}.
FT   METAL        31     31       Zinc. {ECO:0000256|HAMAP-Rule:MF_00383}.
FT   METAL        46     46       Zinc. {ECO:0000256|HAMAP-Rule:MF_00383}.
FT   METAL        49     49       Zinc. {ECO:0000256|HAMAP-Rule:MF_00383}.
SQ   SEQUENCE   324 AA;  36010 MW;  9D7FE47A1EDA83F1 CRC64;
     MTKTQLNIED SPTGEKQSAS EPQPVSSCPE CDGQVIRDDE HGETTCEECG LVLDDVSIDR
     GPEWRTFDGE EKDEKSRVGA PTTQLMHDKG LSTTIGWQNK DAYGQAVSNR KRARLQRLRT
     WDERFRTKDA HERNLKQAFG EISRMASALD MPEPARETAG VLYRRAVDED LLPGRSIEGM
     ATAALYAAAR QHGTPRPLSE FAEVSRVEKI RIQRAYRYLS RELSLQIEPA DPLEYVPQFA
     SALDVSDEAT RQARDLLTTA KAKGTHSGKS PAGLAAAALY AATHLTNEQL TQETVSNAAH
     ISTVTIRNRY QELLDVYAEE EGYA
//
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