ID G2MSK9_9THEO Unreviewed; 502 AA.
AC G2MSK9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 62.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=Thewi_0285 {ECO:0000313|EMBL:AEM77786.1};
OS Thermoanaerobacter wiegelii Rt8.B1.
OC Bacteria; Bacillota; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacteraceae; Thermoanaerobacter.
OX NCBI_TaxID=697303 {ECO:0000313|EMBL:AEM77786.1, ECO:0000313|Proteomes:UP000008276};
RN [1] {ECO:0000313|EMBL:AEM77786.1, ECO:0000313|Proteomes:UP000008276}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rt8.B1 {ECO:0000313|EMBL:AEM77786.1,
RC ECO:0000313|Proteomes:UP000008276};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Zeytun A., Daligault H., Detter J.C., Han C.,
RA Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Hemme C.,
RA Woyke T.;
RT "Complete sequence of Thermoanaerobacter wiegelii Rt8.B1.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP002991; AEM77786.1; -; Genomic_DNA.
DR RefSeq; WP_014062156.1; NC_015958.1.
DR AlphaFoldDB; G2MSK9; -.
DR STRING; 697303.Thewi_0285; -.
DR KEGG; twi:Thewi_0285; -.
DR eggNOG; COG2972; Bacteria.
DR HOGENOM; CLU_020473_5_1_9; -.
DR Proteomes; UP000008276; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR010559; Sig_transdc_His_kin_internal.
DR PANTHER; PTHR34220; SENSOR HISTIDINE KINASE YPDA; 1.
DR PANTHER; PTHR34220:SF7; SENSOR HISTIDINE KINASE YPDA; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF06580; His_kinase; 1.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AEM77786.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 206..259
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 314..496
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT COILED 254..296
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 502 AA; 57543 MW; 109843C1DE675877 CRC64;
MKKDMWRFTG IRRKLIVYYL LITVLMGITS FYSYYNAKSV INRLKSVFVD YIYLNNLNTD
VNTLETEVEK YLSTKSSDAL LNYYTLNNKL QEQASVILNE KNYDQDGLML KDIGNMIESL
LNETDAAINA KRGRISSEYI AHFTRSNKIS EYIKLYINNL LNSKLQEGSL KYASITKNME
FISYLNVFLI IGSILFNIFL AIFFTYRITK PLIDLSHLAV RVSKGDFDVR PLSIKTNDEI
NILAEAFNKM VVSIKNYIGE IKNQAEVEKK LKEQEMQNLK MRNILKEAEL KALQSQINPH
FLFNTLNAAA QLAMMEGADK SSEFIENVAN LFRYNLKKLD TTVTLQDEIN NVKTYMYILK
TRFGDRVDFK VDVDEGVLDI EMPCTIIQPV VENAFIHGLE DTEKGGFIKL TVKKDNDKVL
IEVIDNGIGM SEEKVRAILS ADNEDLSKRH VTGIGMHNII NRLRLFYNTS AIEDVIEIDS
KIGEGTKVTL KIPLMKGDKE ND
//
