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Database: UniProt
Entry: G2NEY8_STREK
LinkDB: G2NEY8_STREK
Original site: G2NEY8_STREK 
ID   G2NEY8_STREK            Unreviewed;       577 AA.
AC   G2NEY8;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   05-JUL-2017, entry version 46.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=SACTE_3308 {ECO:0000313|EMBL:AEN11174.1};
OS   Streptomyces sp. (strain SirexAA-E / ActE).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=862751 {ECO:0000313|EMBL:AEN11174.1, ECO:0000313|Proteomes:UP000001397};
RN   [1] {ECO:0000313|EMBL:AEN11174.1, ECO:0000313|Proteomes:UP000001397}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SirexAA-E / ActE {ECO:0000313|Proteomes:UP000001397};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Ovchinnikova G., Davenport K., Detter J.C., Han C.,
RA   Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I.,
RA   Adams A., Raffa K., Adams S., Book A., Currie C., Woyke T.;
RT   "Complete sequence of Streptomyces sp. SirexAA-E.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP002993; AEN11174.1; -; Genomic_DNA.
DR   ProteinModelPortal; G2NEY8; -.
DR   STRING; 862751.SACTE_3308; -.
DR   EnsemblBacteria; AEN11174; AEN11174; SACTE_3308.
DR   KEGG; ssx:SACTE_3308; -.
DR   PATRIC; fig|862751.12.peg.3442; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   KO; K02313; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000001397; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001397};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001397}.
FT   DOMAIN      270    398       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      484    553       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     278    285       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   577 AA;  64857 MW;  7765D1F621E699E8 CRC64;
     MLDQLLGEGQ QGIEPKDKQW IERCQPLALV ADTALLAVPN EWGKRVLEGR LAPLISETLT
     RECGRPIRIA ITVDDSANEP PTPPAPPMHQ QHQSQGQQPH HYQGPQRDEQ PRNDVYDGYG
     HRPSDDGMPT ARPAYPDYQQ QRPGAWPRSQ EDLSWQPRHG GYQDMDPYAS TRPQQPQHDY
     RPQPPERQGY EPQRDGRDRH DMQEQQPPHH QGGHGRAGGP PGSQSAPAPG TNEPHARLNP
     KYLFDTFVIG ASNRFAHAAA VAVAEAPAKA YNPLFIYGES GLGKTHLLHA IGHYARSLYP
     GTRVRYVSSE EFTNEFINSI RDGKGDTFRK RYRDVDILLV DDIQFLASKE STQEEFFHTF
     NTLHNANKQI VLSSDRPPKQ LVTLEDRLRN RFEWGLTTDV QPPELETRIA ILRKKAVQEQ
     LNAPPEVLEF IASRISRNIR ELEGALIRVT AFASLNRQPV DLGLTEIVLK DLIPGGEDTA
     PEITAPAIMA STADYFGLTV EDLCGSSRSR VLVTARQIAM YLCRELTDLS LPKIGAQFGG
     RDHTTVMHAD RKIRALMAER RSIYNQVTEL TNRIKNG
//
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