ID G2NHE7_STREK Unreviewed; 723 AA.
AC G2NHE7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:AEN09931.1};
DE EC=2.4.1.129 {ECO:0000313|EMBL:AEN09931.1};
GN ORFNames=SACTE_2029 {ECO:0000313|EMBL:AEN09931.1};
OS Streptomyces sp. (strain SirexAA-E / ActE).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=862751 {ECO:0000313|EMBL:AEN09931.1, ECO:0000313|Proteomes:UP000001397};
RN [1] {ECO:0000313|EMBL:AEN09931.1, ECO:0000313|Proteomes:UP000001397}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SirexAA-E / ActE {ECO:0000313|Proteomes:UP000001397};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Ovchinnikova G., Davenport K., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Adams A., Raffa K.,
RA Adams S., Book A., Currie C., Woyke T.;
RT "Complete sequence of Streptomyces sp. SirexAA-E.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AEN09931.1, ECO:0000313|Proteomes:UP000001397}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SirexAA-E / ActE {ECO:0000313|Proteomes:UP000001397};
RX PubMed=24710170; DOI=10.1371/journal.pone.0094166;
RA Takasuka T.E., Acheson J.F., Bianchetti C.M., Prom B.M., Bergeman L.F.,
RA Book A.J., Currie C.R., Fox B.G.;
RT "Biochemical properties and atomic resolution structure of a
RT proteolytically processed beta-mannanase from cellulolytic Streptomyces sp.
RT SirexAA-E.";
RL PLoS ONE 9:e94166-E94166(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; CP002993; AEN09931.1; -; Genomic_DNA.
DR RefSeq; WP_014045917.1; NC_015953.1.
DR AlphaFoldDB; G2NHE7; -.
DR STRING; 862751.SACTE_2029; -.
DR KEGG; ssx:SACTE_2029; -.
DR PATRIC; fig|862751.12.peg.2112; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_1_2_11; -.
DR OMA; SCDTYYY; -.
DR OrthoDB; 9766847at2; -.
DR Proteomes; UP000001397; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR017790; Penicillin-binding_protein_2.
DR NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000313|EMBL:AEN09931.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001397};
KW Transferase {ECO:0000313|EMBL:AEN09931.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 60..246
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 298..657
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 679..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 723 AA; 78603 MW; CE348CBEB2FDB452 CRC64;
MSNIPETGRT QRVQIRLVVI QILVFSLLLT LGGRLWYLQI RNGQEYTDEA KNNHVQQVVQ
PAVRGSILDA RGVPLADNET RLVVSASRTE LMKMKDDGVG VLTRLAEVLD MKPKDVQDKV
RLCDAKTPQP CWNGSPYQPI PVTDEATTQQ ALQIRERAED FPGITAEPTA VRRYAAPGKA
NTAQVLGYLS PVTDEELTKA QDTDSPYLRS DQVGRSGLER TYDKELRGKA GVTRYEVDNL
GRVIGEAQND EAQPGASVVT SIDARVQAVA EYELDQAMKA ARKEMDRNTN EFYKADSGAV
VVMEAKTGRV VSMASLPTYD PNSWVGGISA KDYAELTGKK SNFPLLNRAI QGTAAPGSIF
KVISSTAAVN AGYPFDGNYP CPSSYSIGNQ TFKNFESQGY GNITIGRALE VSCDTVYYGI
AHKEWQKDGG NKPKKNANDW FYKTAHQFGL GKETGIDLPN EVAGRVPDRQ WKQDFYDANR
ESWCKQGKKD GTYVEQLAYE GCAEGYKMRA GDSVNYSIGQ GDTLVTPIQM ATIYAAISNG
GTLYDPTVGK AIVSGDGRTV QEIEPQAHGK LPFTGDTRDK IDQALAGVAT QGSAAWRFGG
WPQDKIPMHA KTGTAEVYGK QTTSWFATYT KDYSIVMTIS QGGTGSGASG PAVRNIYNAI
YGLDGEGKQD LKKALLPQPQ KALPKITPDG SIVSPKIKPY TPEPPADEGT QALALAVAPG
RRD
//