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Database: UniProt
Entry: G2P9P5_STRVO
LinkDB: G2P9P5_STRVO
Original site: G2P9P5_STRVO 
ID   G2P9P5_STRVO            Unreviewed;       605 AA.
AC   G2P9P5;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   05-JUL-2017, entry version 45.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=Strvi_0251 {ECO:0000313|EMBL:AEM80039.1};
OS   Streptomyces violaceusniger Tu 4113.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=653045 {ECO:0000313|EMBL:AEM80039.1, ECO:0000313|Proteomes:UP000008703};
RN   [1] {ECO:0000313|EMBL:AEM80039.1, ECO:0000313|Proteomes:UP000008703}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tu 4133 {ECO:0000313|Proteomes:UP000008703};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Ivanova N., Daligault H., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Hagen A.,
RA   Katz L., Fiedler H.-P., Keasling J., Fortman J., Woyke T.;
RT   "Complete sequence of chromosome of Streptomyces violaceusniger Tu
RT   4113.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP002994; AEM80039.1; -; Genomic_DNA.
DR   STRING; 653045.Strvi_0251; -.
DR   EnsemblBacteria; AEM80039; AEM80039; Strvi_0251.
DR   KEGG; svl:Strvi_0251; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   KO; K02313; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000008703; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008703};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008703}.
FT   DOMAIN      298    426       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      512    581       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     306    313       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   605 AA;  66506 MW;  1BC2B6F32BEC55C8 CRC64;
     MLERLLGEGS GQGGQGVEAK DEHWIKRCQP LALVADTALL AVPNEFAKGV LEGRLAPVVS
     ETLSRECGRP IRIAITVDES AGEPVVPPQV QREQRESYEN REQRESYESY DGRDGYGRQA
     PDDLPSARPA YPGYQQSRPE PGAWPRPRDD YGWQQPRLGG FPEGDPYASQ HAPSGYGQQP
     YDQQRRGDYR GPGAERPGPG GPGGGPGGGP GPGPERPPYE QRHDLPDPLE RARGGPPLLP
     SQTGAPGPLA AQPAPASGPG EPTARLNPKY LFDTFVIGAS NRFAHAAAVA VAEAPAKAYN
     PLFIYGESGL GKTHLLHAIG HYARSLYPGT RVRYVSSEEF TNEFINSIRD GKADAFRRRY
     RDMDILLVDD IQFLASKEST QEEFFHTFNT LHNANKQIVL SSDRPPKQLV TLEDRLRNRF
     EWGLITDVQP PELETRIAIL RKKAVQEQLN APPEVLEFIA SRISRNIREL EGALIRVTAF
     ASLNRQPVDL GLAEIVLKDL IPGGEDAAPE ITATAIMAAT ADYFGHTVDD LCGASRSRVL
     VTARQIAMYL CRELTDLSLP KIGAQFGGRD HTTVMHADRK IRALMAERRS IYNQVTELTN
     RIKNG
//
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