ID   G2T327_ROSHA            Unreviewed;       511 AA.
AC   G2T327;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 65.
DE   SubName: Full=Cardiolipin synthetase {ECO:0000313|EMBL:AEN96803.1};
GN   OrderedLocusNames=RHOM_08450 {ECO:0000313|EMBL:AEN96803.1};
OS   Roseburia hominis (strain DSM 16839 / JCM 17582 / NCIMB 14029 / A2-183).
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX   NCBI_TaxID=585394 {ECO:0000313|EMBL:AEN96803.1, ECO:0000313|Proteomes:UP000008178};
RN   [1] {ECO:0000313|EMBL:AEN96803.1, ECO:0000313|Proteomes:UP000008178}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16839 / JCM 17582 / NCIMB 14029 / A2-183
RC   {ECO:0000313|Proteomes:UP000008178};
RX   PubMed=26543119; DOI=10.1128/genomeA.01286-15;
RA   Travis A.J., Kelly D., Flint H.J., Aminov R.I.;
RT   "Complete genome sequence of the human gut symbiont Roseburia hominis.";
RL   Genome Announc. 3:E0128615-E0128615(2015).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; CP003040; AEN96803.1; -; Genomic_DNA.
DR   RefSeq; WP_014079842.1; NC_015977.1.
DR   AlphaFoldDB; G2T327; -.
DR   STRING; 585394.RHOM_08450; -.
DR   GeneID; 77459300; -.
DR   KEGG; rho:RHOM_08450; -.
DR   eggNOG; COG1502; Bacteria.
DR   HOGENOM; CLU_038053_1_2_9; -.
DR   OrthoDB; 9762009at2; -.
DR   BioCyc; RHOM585394:G1H02-1691-MONOMER; -.
DR   Proteomes; UP000008178; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008808; F:cardiolipin synthase activity; IEA:InterPro.
DR   GO; GO:0032049; P:cardiolipin biosynthetic process; IEA:InterPro.
DR   CDD; cd09154; PLDc_SMU_988_like_1; 1.
DR   CDD; cd09160; PLDc_SMU_988_like_2; 1.
DR   Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR   InterPro; IPR022924; Cardiolipin_synthase.
DR   InterPro; IPR027379; CLS_N.
DR   InterPro; IPR025202; PLD-like_dom.
DR   InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR   NCBIfam; TIGR04265; bac_cardiolipin; 1.
DR   PANTHER; PTHR21248; CARDIOLIPIN SYNTHASE; 1.
DR   PANTHER; PTHR21248:SF22; PHOSPHOLIPASE D; 1.
DR   Pfam; PF13091; PLDc_2; 2.
DR   Pfam; PF13396; PLDc_N; 1.
DR   SMART; SM00155; PLDc; 2.
DR   SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR   PROSITE; PS50035; PLD; 2.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW   Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008178};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        37..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        68..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          244..271
FT                   /note="PLD phosphodiesterase"
FT                   /evidence="ECO:0000259|PROSITE:PS50035"
FT   DOMAIN          424..451
FT                   /note="PLD phosphodiesterase"
FT                   /evidence="ECO:0000259|PROSITE:PS50035"
SQ   SEQUENCE   511 AA;  58640 MW;  85EDF4B9706828F0 CRC64;
     MKKIAHLLMG RLTIVGVSIL LQICWLFLVL WKFSYQFTYA NLIIRAAAIV LVLVIANKWE
     NPANKLSWTF LILLSPILGI MLYFLFGRSG LTKHTREQMD AVNREVDACM PVDEEAVRLL
     QEADPSVLRQ SKYIADWGHF PVYRNTATKY YESGEAMFPD MLAALESAEH FIFLEYFIIE
     EGHMFHQIED ILEKKVKEGV EVRLIYDDVG CIGTLPPRYY KQLQKKGIKC AAFNPFRPLL
     SVIMNNRDHR KIFVVDGAVG FTGGINLADE YINEVKRFGY WKDTGVRIEG EAVWSLTSMF
     LSMWNYIVHS TEDYSRFMPA QHQKAPFEND GFVQPYGDSP LDHENVGENI YLNIINRAKN
     YVYIFTPYLI IDHEMLTALC NAAKDGVDVR IVTPGIPDKK MIFLLTQSYY APLIQSGVKI
     YQYTPGFIHA KCFVCDDEIA TVGSVNLDFR SLYLHFECGV FFYRSAVVAQ VKEDCLNTFA
     CSEQMTAEFC RNRPVPVRLL QSVLRLLAPL L
//