ID G2W8Q0_YEASK Unreviewed; 1191 AA.
AC G2W8Q0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=K7_Swh1p {ECO:0000313|EMBL:GAA21443.1};
GN Name=K7_SWH1 {ECO:0000313|EMBL:GAA21443.1};
GN ORFNames=SYK7_001351 {ECO:0000313|EMBL:GAA21443.1};
OS Saccharomyces cerevisiae (strain Kyokai no. 7 / NBRC 101557) (Baker's
OS yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=721032 {ECO:0000313|EMBL:GAA21443.1, ECO:0000313|Proteomes:UP000001608};
RN [1] {ECO:0000313|EMBL:GAA21443.1, ECO:0000313|Proteomes:UP000001608}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Kyokai no. 7 / NBRC 101557 {ECO:0000313|Proteomes:UP000001608};
RX PubMed=21900213; DOI=10.1093/dnares/dsr029;
RA Akao T., Yashiro I., Hosoyama A., Kitagaki H., Horikawa H., Watanabe D.,
RA Akada R., Ando Y., Harashima S., Inoue T., Inoue Y., Kajiwara S.,
RA Kitamoto K., Kitamoto N., Kobayashi O., Kuhara S., Masubuchi T.,
RA Mizoguchi H., Nakao Y., Nakazato A., Namise M., Oba T., Ogata T., Ohta A.,
RA Sato M., Shibasaki S., Takatsume Y., Tanimoto S., Tsuboi H., Nishimura A.,
RA Yoda K., Ishikawa T., Iwashita K., Fujita N., Shimoi H.;
RT "Whole-genome sequencing of sake yeast Saccharomyces cerevisiae Kyokai no.
RT 7.";
RL DNA Res. 18:423-434(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000256|ARBA:ARBA00008842,
CC ECO:0000256|RuleBase:RU003844}.
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DR EMBL; DG000037; GAA21443.1; -; Genomic_DNA.
DR AlphaFoldDB; G2W8Q0; -.
DR HOGENOM; CLU_001040_1_1_1; -.
DR Proteomes; UP000001608; Chromosome I.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0120015; F:sterol transfer activity; IEA:UniProt.
DR GO; GO:0006897; P:endocytosis; IEA:UniProt.
DR GO; GO:0006887; P:exocytosis; IEA:UniProt.
DR GO; GO:0030011; P:maintenance of cell polarity; IEA:UniProt.
DR GO; GO:0034727; P:piecemeal microautophagy of the nucleus; IEA:UniProt.
DR CDD; cd13292; PH_Osh1p_Osh2p_yeast; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972:SF205; OXYSTEROL-BINDING PROTEIN; 1.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT REPEAT 96..118
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 196..228
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 281..379
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 415..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 664..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 723..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..514
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1191 AA; 135379 MW; 7E5CB16E960F800D CRC64;
MEQPDLSSVA ISKPLLKLKL LDALRQGSFP NLQDLLKKQF QPLDDPNVQQ VLHLMLHYAV
QVAPMAVIKE IVHHWVSTTN TTFLNIHLDL NERDSNGNTP LHIAAYQSRG DIVAFLLDQP
TINDCVLNNS HLQAIEMCKN LNIAQMMQVK RSTYVAETAQ EFRTAFNNRD FGHLESILSS
PRNAELLDIN GMDPETGDTV LHEFVKKRDV IMCRWLLEHG ADPFKRDRKG KLPIELVRKV
NENYTATNTK IAIDIELKKL LERATREQSV IDVTNNNLHE APTYKGYLKK WTNFAQGYKL
RWFILSSDGK LSYYIDQADT KNACRGSLNM SSCSLHLDSS EKLKFEIIGG NNGVIRWHLK
GNHPIETNRW VWAIQGAIRY AKDREILLHN GPYSPSLALS HGLSSKVSNK ENLHATSKRL
TKSPHLSKST LTQNDHDNDD DSTNNNNNKS NNDYDDNNNN NNNNNDDDDY DDDDDESRPL
IEPLPLISSR SQSLSEIASG PHSRKSTVSS TRAADIPSDD EGYSEDDSDD DGNSSYTMEN
GGENDGDEDL NAIYGPYIQK LHMLQRSISI ELASLNELLQ DKQQHDEYWN TVNTSIETVS
EFFDKLNRLT SQREKRMIAQ MTKQRDVNNV WIQSVKDLEM ELVDKDEKLV ALDKERKNLK
KMLQKKLNNQ PQVETEANEE SDDANSMIKG SQESTNTLEE IVKFIEATKE SDEDSDADEF
FDAEEAASDK KTNDSENLTT SKETPANAKP QEEAPEDESL IVISSPQVEK KNQLLKEGSF
VGYEDPVRTK LALDEDNRPK IGLWSVLKSM VGQDLTKLTL PVSFNEPTSL LQRVSEDIEY
SHILDQAATF EDSSLRMLYV AAFTASMYAS TTNRVSKPFN PLLGETFEYA RTDGQYRFFT
EQVSHHPPIS ATWTESPKWD FYGECNVDSS FNGRTFAVQH LGLWYITIRP DHNISVPEET
YSWKKPNNTV IGILMGKPQV DNSGDVKVTN HTTGDYCMLH YKAHGWTSAG AYEVRGEVFN
KDGKKLWVLG GHWNDSIYGK KVTARGGELT LDRIKTANSA TGGPKLDGSK FLIWKANERP
SVPFNLTSFA LTLNALPPHL VPYLAPTDSR LRPDQRAMEN GEYDKAAAEK HRVEVKQRAA
KKEREQKGEE YRPKWFVQEE HPVTKSLYWK FNGEYWNKRK NHDFKDCADI F
//
