ID G2WS59_VERDV Unreviewed; 485 AA.
AC G2WS59;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=NEDD8-activating enzyme E1 regulatory subunit {ECO:0000256|PIRNR:PIRNR039099};
GN ORFNames=VDAG_00392 {ECO:0000313|EMBL:EGY13710.1};
OS Verticillium dahliae (strain VdLs.17 / ATCC MYA-4575 / FGSC 10137)
OS (Verticillium wilt).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX NCBI_TaxID=498257 {ECO:0000313|EMBL:EGY13710.1, ECO:0000313|Proteomes:UP000001611};
RN [1] {ECO:0000313|Proteomes:UP000001611}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VdLs.17 / ATCC MYA-4575 / FGSC 10137
RC {ECO:0000313|Proteomes:UP000001611};
RX PubMed=21829347; DOI=10.1371/journal.ppat.1002137;
RA Klosterman S.J., Subbarao K.V., Kang S., Veronese P., Gold S.E.,
RA Thomma B.P.H.J., Chen Z., Henrissat B., Lee Y.-H., Park J.,
RA Garcia-Pedrajas M.D., Barbara D.J., Anchieta A., de Jonge R., Santhanam P.,
RA Maruthachalam K., Atallah Z., Amyotte S.G., Paz Z., Inderbitzin P.,
RA Hayes R.J., Heiman D.I., Young S., Zeng Q., Engels R., Galagan J.,
RA Cuomo C.A., Dobinson K.F., Ma L.-J.;
RT "Comparative genomics yields insights into niche adaptation of plant
RT vascular wilt pathogens.";
RL PLoS Pathog. 7:E1002137-E1002137(2011).
CC -!- FUNCTION: Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.
CC {ECO:0000256|PIRNR:PIRNR039099}.
CC -!- PATHWAY: Protein modification; protein neddylation.
CC {ECO:0000256|ARBA:ARBA00005032, ECO:0000256|PIRNR:PIRNR039099}.
CC -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family. ULA1
CC subfamily. {ECO:0000256|ARBA:ARBA00006868,
CC ECO:0000256|PIRNR:PIRNR039099}.
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DR EMBL; DS572695; EGY13710.1; -; Genomic_DNA.
DR RefSeq; XP_009650064.1; XM_009651769.1.
DR AlphaFoldDB; G2WS59; -.
DR STRING; 498257.G2WS59; -.
DR EnsemblFungi; EGY13710; EGY13710; VDAG_00392.
DR GeneID; 20701855; -.
DR KEGG; vda:VDAG_00392; -.
DR eggNOG; KOG2016; Eukaryota.
DR HOGENOM; CLU_019618_1_0_1; -.
DR InParanoid; G2WS59; -.
DR OMA; KLITHQY; -.
DR OrthoDB; 5488891at2759; -.
DR UniPathway; UPA00885; -.
DR Proteomes; UP000001611; Chromosome 2.
DR GO; GO:0019781; F:NEDD8 activating enzyme activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045116; P:protein neddylation; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR030667; APP-BP1.
DR InterPro; IPR045886; ThiF/MoeB/HesA.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR PANTHER; PTHR10953:SF29; NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR Pfam; PF00899; ThiF; 1.
DR PIRSF; PIRSF039099; APP-BP1; 2.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001611};
KW Ubl conjugation pathway {ECO:0000256|PIRNR:PIRNR039099}.
FT DOMAIN 25..476
FT /note="THIF-type NAD/FAD binding fold"
FT /evidence="ECO:0000259|Pfam:PF00899"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 485 AA; 52615 MW; B3E7DBA8D1F72522 CRC64;
MTEVATIQTQ TPPLLSGPSE KERKYDRQLR LWAASGQAAL ESSHILLVNS SSGTMGVETL
KNLVLPGIGK FTIADGANVQ EADLGVNFFL DASSLGKPRA QACADLLVEL NPEVKADWFP
KNSEPYDLAK VLESPEPYTI ILYALPIKPE DLQILESYAT DHKTPLIAAH SVGFYAYFRV
HLPAAFPIVW KQSHQGEYPS TYQDKVAFRR VVAEAARTDT PEGGEENFDE AAAAVLKTIS
PPSLPDSLRH VFEYQSADLE ETQSSFWIIA GAVKAFYEKH KCLPVPGGLP DMKAQSSVYI
RLQGIYKAKA RKDAAEVLDS VRRAPGGEHV DPAEVDLFCK NAAFVKLIDA KDGGTERLLK
VADEELANDD MAAMGVMPTS LLPIYLALRA TSHALDTAAA GAALSPETIL KNVTALVPRA
TESERYAQAA QEVSRAAGGE LHNVSAVMGG LVAQEMIKII TKQYIPVHNT CIFDGIGSRC
QVLRL
//
