ID G2XCE9_VERDV Unreviewed; 466 AA.
AC G2XCE9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=tRNA guanosine-2'-O-methyltransferase TRM11 {ECO:0000313|EMBL:EGY16667.1};
GN ORFNames=VDAG_07831 {ECO:0000313|EMBL:EGY16667.1};
OS Verticillium dahliae (strain VdLs.17 / ATCC MYA-4575 / FGSC 10137)
OS (Verticillium wilt).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX NCBI_TaxID=498257 {ECO:0000313|EMBL:EGY16667.1};
RN [1] {ECO:0000313|EMBL:EGY16667.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VdLs.17 {ECO:0000313|EMBL:EGY16667.1};
RG The Broad Institute Genome Sequencing Platform;
RA Ma L.-J.J., Klosterman S.J., Subbarao K., Dobinson K., Veronese P.,
RA Kang S., Gold S.E., Young S., Jaffe D., Gnerre S., Berlin A., Heiman D.,
RA Hepburn T., Sykes S., Alvarado L., Kodira C.D., Lander E., Galagan J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Verticillium dahliae VdLs.17.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalytic subunit of an S-adenosyl-L-methionine-dependent
CC tRNA methyltransferase complex that mediates the methylation of the
CC guanosine nucleotide at position 10 (m2G10) in tRNAs.
CC {ECO:0000256|ARBA:ARBA00002425}.
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DR EMBL; DS572712; EGY16667.1; -; Genomic_DNA.
DR RefSeq; XP_009650892.1; XM_009652597.1.
DR AlphaFoldDB; G2XCE9; -.
DR STRING; 498257.G2XCE9; -.
DR EnsemblFungi; EGY16667; EGY16667; VDAG_07831.
DR GeneID; 20709294; -.
DR KEGG; vda:VDAG_07831; -.
DR eggNOG; KOG2671; Eukaryota.
DR HOGENOM; CLU_029646_3_0_1; -.
DR InParanoid; G2XCE9; -.
DR OMA; QAFNKWS; -.
DR OrthoDB; 5488599at2759; -.
DR GO; GO:0005737; C:cytoplasm; IEA:EnsemblFungi.
DR GO; GO:0043528; C:tRNA (m2G10) methyltransferase complex; IEA:EnsemblFungi.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0160102; F:tRNA (guanine(10)-N2)-methyltransferase activity; IEA:EnsemblFungi.
DR GO; GO:0030488; P:tRNA methylation; IEA:EnsemblFungi.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016691; tRNA_mtfrase_TRM11.
DR PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR PANTHER; PTHR13370:SF3; TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG; 1.
DR Pfam; PF01170; UPF0020; 1.
DR PIRSF; PIRSF017259; tRNA_mtfrase_TRM11; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
DR PROSITE; PS51627; SAM_MT_TRM11; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022555};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555}.
FT DOMAIN 185..298
FT /note="UPF0020"
FT /evidence="ECO:0000259|Pfam:PF01170"
SQ SEQUENCE 466 AA; 53160 MW; 29A357B20761B741 CRC64;
MDYLVRFSQF HESFRLAELK ALAVVEGIDL KILEYSDDHP FCIITVPSAD AARALIRRAI
LIQSIHELWG YAPSGLYEDI HADVRARTEP LWSSYATCSF KFIVDAFQHT RTMDERVQLI
NSFSYLAFQG RIDMRAPDET FTIFEDWPFR PAGVRPEPNP RRLFLGRWLG GGSRELCRTY
DLKKRGYIST TSMDSELALV TANMALAAPG KIFYDPFVGT GSFPVAAAHF GALAFGSDID
GRSFRGQGGQ KSLKGNFAQY GLEQLVGEFF TADLTNTPLV RRRWMDGIVC DPPYGVREGL
KMLGCRDPEK TPNVIVAGEK YWKSVALFFS LCRFLLRNRL LIVTSSPSYI APKKPYSFLA
MLDDILEFAT QMLVDEGRLT FWMPTANDED QELNVPTHPC LEIVSVCVQP FNRWSRRLIT
YRRMPDSQVD QEKLSLHKRA KHEGVTADEL NPFRERYFKG FKKEEA
//
