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Database: UniProt
Entry: G2XG17_VERDV
LinkDB: G2XG17_VERDV
Original site: G2XG17_VERDV 
ID   G2XG17_VERDV            Unreviewed;       236 AA.
AC   G2XG17;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   24-JAN-2024, entry version 43.
DE   RecName: Full=Orotate phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00014769};
DE            EC=2.4.2.10 {ECO:0000256|ARBA:ARBA00011971};
GN   ORFNames=VDAG_08996 {ECO:0000313|EMBL:EGY18836.1};
OS   Verticillium dahliae (strain VdLs.17 / ATCC MYA-4575 / FGSC 10137)
OS   (Verticillium wilt).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX   NCBI_TaxID=498257 {ECO:0000313|EMBL:EGY18836.1};
RN   [1] {ECO:0000313|EMBL:EGY18836.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=VdLs.17 {ECO:0000313|EMBL:EGY18836.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Ma L.-J.J., Klosterman S.J., Subbarao K., Dobinson K., Veronese P.,
RA   Kang S., Gold S.E., Young S., Jaffe D., Gnerre S., Berlin A., Heiman D.,
RA   Hepburn T., Sykes S., Alvarado L., Kodira C.D., Lander E., Galagan J.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Verticillium dahliae VdLs.17.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the transfer of a ribosyl phosphate group from 5-
CC       phosphoribose 1-diphosphate to orotate, leading to the formation of
CC       orotidine monophosphate (OMP). {ECO:0000256|ARBA:ARBA00003769}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-
CC         ribose 1-diphosphate + orotate; Xref=Rhea:RHEA:10380,
CC         ChEBI:CHEBI:30839, ChEBI:CHEBI:33019, ChEBI:CHEBI:57538,
CC         ChEBI:CHEBI:58017; EC=2.4.2.10;
CC         Evidence={ECO:0000256|ARBA:ARBA00001431};
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC       UMP from orotate: step 1/2. {ECO:0000256|ARBA:ARBA00004889}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC       family. PyrE subfamily. {ECO:0000256|ARBA:ARBA00006340}.
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DR   EMBL; DS572718; EGY18836.1; -; Genomic_DNA.
DR   RefSeq; XP_009655094.1; XM_009656799.1.
DR   AlphaFoldDB; G2XG17; -.
DR   STRING; 498257.G2XG17; -.
DR   EnsemblFungi; EGY18836; EGY18836; VDAG_08996.
DR   GeneID; 20710459; -.
DR   KEGG; vda:VDAG_08996; -.
DR   eggNOG; KOG1377; Eukaryota.
DR   HOGENOM; CLU_074878_0_0_1; -.
DR   InParanoid; G2XG17; -.
DR   OMA; SPFFMNA; -.
DR   OrthoDB; 276022at2759; -.
DR   UniPathway; UPA00070; UER00119.
DR   GO; GO:0004588; F:orotate phosphoribosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   Gene3D; 3.40.50.2020; -; 1.
DR   HAMAP; MF_01208; PyrE; 1.
DR   InterPro; IPR023031; OPRT.
DR   InterPro; IPR004467; Or_phspho_trans_dom.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   NCBIfam; TIGR00336; pyrE; 1.
DR   PANTHER; PTHR46683; OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED; 1.
DR   PANTHER; PTHR46683:SF1; OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED; 1.
DR   Pfam; PF00156; Pribosyltran; 1.
DR   SUPFAM; SSF53271; PRTase-like; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase {ECO:0000313|EMBL:EGY18836.1};
KW   Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          70..181
FT                   /note="Phosphoribosyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00156"
SQ   SEQUENCE   236 AA;  25681 MW;  033D73E464878387 CRC64;
     MAGQLPQWKQ DFLQAAISGK ILKFGSFELK SKRISPYFFN AGDFYRADLL RAISLAYAHA
     IIEATKDAAN PLRFDIVFGP AYKGIPLATA AVDKLAELDS ATFGHTCYSF DRKEAKDHGE
     GGNIVGAPLK GKRVLIVDDV ITAGTAKREA IAKIRAEGGE VAGIVVALDR MEKLPSPDGD
     DSKPMPSAMG EIKKEYGIPI YAILTLDDII EGMKGFASEE DTKRTQEYRA KYKASD
//
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