ID G2Y390_BOTF4 Unreviewed; 903 AA.
AC G2Y390;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE RecName: Full=Anaphase-promoting complex subunit 2 {ECO:0000256|ARBA:ARBA00016068};
GN ORFNames=BofuT4_P002890.1 {ECO:0000313|EMBL:CCD47130.1};
OS Botryotinia fuckeliana (strain T4) (Noble rot fungus) (Botrytis cinerea).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Sclerotiniaceae; Botrytis.
OX NCBI_TaxID=999810 {ECO:0000313|EMBL:CCD47130.1, ECO:0000313|Proteomes:UP000008177};
RN [1] {ECO:0000313|Proteomes:UP000008177}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T4 {ECO:0000313|Proteomes:UP000008177};
RX PubMed=21876677; DOI=.1371/journal.pgen.1002230;
RA Amselem J., Cuomo C.A., van Kan J.A., Viaud M., Benito E.P., Couloux A.,
RA Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E.,
RA Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.M.,
RA Quevillon E., Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P.,
RA Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I.,
RA Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P.,
RA Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C.,
RA Grossetete S., Guldener U., Henrissat B., Howlett B.J., Kodira C.,
RA Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E.,
RA Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N.,
RA Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E.,
RA Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O.,
RA Zeng Q., Rollins J.A., Lebrun M.H., Dickman M.;
RT "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia
RT sclerotiorum and Botrytis cinerea.";
RL PLoS Genet. 7:E1002230-E1002230(2011).
CC -!- SIMILARITY: Belongs to the cullin family. {ECO:0000256|PROSITE-
CC ProRule:PRU00330, ECO:0000256|RuleBase:RU003829}.
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DR EMBL; FQ790286; CCD47130.1; -; Genomic_DNA.
DR AlphaFoldDB; G2Y390; -.
DR STRING; 999810.G2Y390; -.
DR eggNOG; KOG2165; Eukaryota.
DR HOGENOM; CLU_007149_0_0_1; -.
DR InParanoid; G2Y390; -.
DR Proteomes; UP000008177; Unplaced contigs.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR044554; APC2-like.
DR InterPro; IPR014786; APC2_C.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45957; ANAPHASE-PROMOTING COMPLEX SUBUNIT 2; 1.
DR PANTHER; PTHR45957:SF1; ANAPHASE-PROMOTING COMPLEX SUBUNIT 2; 1.
DR Pfam; PF08672; ANAPC2; 1.
DR Pfam; PF00888; Cullin; 1.
DR SMART; SM01013; APC2; 1.
DR SMART; SM00182; CULLIN; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000008177};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 564..777
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
FT REGION 13..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 806..831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 903 AA; 101225 MW; 6B66744AF9EA0F4C CRC64;
MATFATKRKR VLDSVFKKPE ISEPTPVATP TGSFTTSSQP FGESQSFNHG PKTPSSNTRS
SQQLRGHDRD SSVAQVRDQI QWDRSWHTVT YRLQLPDVPL DTGSIETLRP LSILSDPSFD
DALKDVLDPV NRLPFALHTD DLLVWHTQQV RRHLLRQILP VLRLYADEEG PRSLVFGSVK
ILDFAHRMYL HGLSVILKQV ELFTPGLSRV ILEKFRRDLH AIITNSLTDQ FIAALRTVLE
NYVSSILGLQ GKKGSGIAPI DARTDKVCNE MLNLVESLHK VGLAGEKFEV IFAEIMNHSM
TEYVNRGCKG LWSATEINIT PQDGERRNSV LPRTAHHVSP SNCVTDLCGW IGDRYSKLAV
LVFKVIDNVE VAWSDMERWK EMSIGRLAAL RTDELFDIVV NWPNSNGALH DLRTTITTPQ
RRLHLTEAFA ATLKERLLHP GASTLLILQT YISMIWSFHS LDHSKVLLDR VAYPLQVYLC
SREDTVRIII TGLLSDTEDA QGNPIESGGD RLIELAHLLN NDSEHSGQKI DDEELDWHDM
EWVPDPVDAG PGYKRSKSAD IIGTLIGVFG SQDVFIKEFQ NIISENLLKN DGAYEKEIKV
LELLKSRFGE APLQSCEVML KDILDSVRLD LAIHKTQDLS IAERKAMPPP PTQPILHTKI
LSRLFWPPLQ ESTFTLPPQI TNLQSDYSTA FSSLKPSRKL TWLPALGHTT VELELADRTV
VEECTTWQAT VISCFHSETT HHNPDDEDLP AQKSIEELTS ELEMDSVLIL SALKFWVSKL
VLQESPPKSQ VYSVLETLNA SDRARSDALA SAPVGADHGD DEGEGETEEK GIAGENAKVY
WQFVQSMLTN SSSQMGAPQI AMMLKMLIAE GFPYSNEELL EWLGGKVEEG VLECVGGRYR
LKK
//
