ID G3B6L8_CANTC Unreviewed; 329 AA.
AC G3B6L8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=NAD(P)-binding protein {ECO:0000313|EMBL:EGV63500.1};
GN ORFNames=CANTEDRAFT_114803 {ECO:0000313|EMBL:EGV63500.1};
OS Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC
OS 10315 / NRRL Y-1498 / VKM Y-70) (Yeast) (Yamadazyma tenuis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Yamadazyma.
OX NCBI_TaxID=590646 {ECO:0000313|Proteomes:UP000000707};
RN [1] {ECO:0000313|EMBL:EGV63500.1, ECO:0000313|Proteomes:UP000000707}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 /
RC NRRL Y-1498 / VKM Y-70 {ECO:0000313|Proteomes:UP000000707};
RX PubMed=21788494; DOI=10.1073/pnas.1103039108;
RA Wohlbach D.J., Kuo A., Sato T.K., Potts K.M., Salamov A.A., LaButti K.M.,
RA Sun H., Clum A., Pangilinan J.L., Lindquist E.A., Lucas S., Lapidus A.,
RA Jin M., Gunawan C., Balan V., Dale B.E., Jeffries T.W., Zinkel R.,
RA Barry K.W., Grigoriev I.V., Gasch A.P.;
RT "Comparative genomics of xylose-fermenting fungi for enhanced biofuel
RT production.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:13212-13217(2011).
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. Dihydroflavonol-4-reductase subfamily.
CC {ECO:0000256|ARBA:ARBA00023445}.
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DR EMBL; GL996524; EGV63500.1; -; Genomic_DNA.
DR RefSeq; XP_006687293.1; XM_006687230.1.
DR AlphaFoldDB; G3B6L8; -.
DR STRING; 590646.G3B6L8; -.
DR GeneID; 18247588; -.
DR KEGG; cten:CANTEDRAFT_114803; -.
DR eggNOG; KOG1502; Eukaryota.
DR HOGENOM; CLU_007383_9_2_1; -.
DR OrthoDB; 1694166at2759; -.
DR Proteomes; UP000000707; Unassembled WGS sequence.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10366; NAD DEPENDENT EPIMERASE/DEHYDRATASE; 1.
DR PANTHER; PTHR10366:SF242; STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000000707}.
FT DOMAIN 5..174
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 329 AA; 37080 MW; AD2CDE600BEE148B CRC64;
MSTVLVTGAT GHTGVFTVLE YIKNGYKVNT TMRDISQLSE VKEMIQKTGN LSDEAMKNIR
YFQADLGKEE GWKEAIDGCE YVCHVAYPFI NNVPLEQIYD AAITGTMNLL NLAANTESVK
QFIFCSSFAA IGFADSYPEG TIVNDDSWTP EDAKILDGYM KSKILVEKMM WKFIKSSENK
RGMSFTSIAP YMISGPLPWG YRKLVGVMGL IKLYITGGLD VILHYHLNNS DVRDLSKSFV
SATNNKEAFN ERFLLVEEKE HLMSEIVDIL KRDFPAKYSE KVPTAVSPPL TISKITDSSK
ARRILNFNPI PFEESIKQSI ENIIERENL
//
