ID G3B7G4_CANTC Unreviewed; 451 AA.
AC G3B7G4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Autophagy-related protein 17 {ECO:0000256|ARBA:ARBA00013806, ECO:0000256|RuleBase:RU368080};
GN ORFNames=CANTEDRAFT_131642 {ECO:0000313|EMBL:EGV62272.1};
OS Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC
OS 10315 / NRRL Y-1498 / VKM Y-70) (Yeast) (Yamadazyma tenuis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Yamadazyma.
OX NCBI_TaxID=590646 {ECO:0000313|Proteomes:UP000000707};
RN [1] {ECO:0000313|EMBL:EGV62272.1, ECO:0000313|Proteomes:UP000000707}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 /
RC NRRL Y-1498 / VKM Y-70 {ECO:0000313|Proteomes:UP000000707};
RX PubMed=21788494; DOI=10.1073/pnas.1103039108;
RA Wohlbach D.J., Kuo A., Sato T.K., Potts K.M., Salamov A.A., LaButti K.M.,
RA Sun H., Clum A., Pangilinan J.L., Lindquist E.A., Lucas S., Lapidus A.,
RA Jin M., Gunawan C., Balan V., Dale B.E., Jeffries T.W., Zinkel R.,
RA Barry K.W., Grigoriev I.V., Gasch A.P.;
RT "Comparative genomics of xylose-fermenting fungi for enhanced biofuel
RT production.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:13212-13217(2011).
CC -!- FUNCTION: Autophagy-specific protein that functions in response to
CC autophagy-inducing signals as a scaffold to recruit other ATG proteins
CC to organize preautophagosomal structure (PAS) formation. Modulates the
CC timing and magnitude of the autophagy response, such as the size of the
CC sequestering vesicles. Plays particularly a role in pexophagy and
CC nucleophagy. {ECO:0000256|RuleBase:RU368080}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU368080}.
CC Preautophagosomal structure membrane {ECO:0000256|RuleBase:RU368080};
CC Peripheral membrane protein {ECO:0000256|RuleBase:RU368080}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the ATG17 family.
CC {ECO:0000256|ARBA:ARBA00006259, ECO:0000256|RuleBase:RU368080}.
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DR EMBL; GL996527; EGV62272.1; -; Genomic_DNA.
DR RefSeq; XP_006688442.1; XM_006688379.1.
DR AlphaFoldDB; G3B7G4; -.
DR STRING; 590646.G3B7G4; -.
DR GeneID; 18249546; -.
DR KEGG; cten:CANTEDRAFT_131642; -.
DR eggNOG; ENOG502RW77; Eukaryota.
DR HOGENOM; CLU_565132_0_0_1; -.
DR OrthoDB; 2047735at2759; -.
DR Proteomes; UP000000707; Unassembled WGS sequence.
DR GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR InterPro; IPR007240; Atg17.
DR InterPro; IPR045326; ATG17-like_dom.
DR PANTHER; PTHR28005; AUTOPHAGY-RELATED PROTEIN 17; 1.
DR PANTHER; PTHR28005:SF1; AUTOPHAGY-RELATED PROTEIN 17; 1.
DR Pfam; PF04108; ATG17_like; 1.
PE 3: Inferred from homology;
KW Autophagy {ECO:0000256|RuleBase:RU368080};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU368080};
KW Reference proteome {ECO:0000313|Proteomes:UP000000707}.
FT DOMAIN 20..404
FT /note="Autophagy protein ATG17-like"
FT /evidence="ECO:0000259|Pfam:PF04108"
FT COILED 203..230
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 451 AA; 53295 MW; 34DE2F6A725151FF CRC64;
MNEFSRDNLI ECRDHAKKAL NEARELCNTA NTSISNLINK LVVELSDHLE HIDAKYKQFQ
MVNDLIANYI AFLNDKVHND CIGKYNVEYA KLQQVMQEFN EIIDSLDKVK VPEFLIQESS
TNDLSLEQGV SLKHFISVDE IELLFGNISI HHENMTKLHE FMDKSFRETA QLPFNKVINK
RFQQMFKTHD DLMTFQSMNN DGIQSILKEN ESLEQELVSL LQMLTNHYDQ CMVGLNEFGK
SSLHINYDVL AQDSEESVSV LKDLRSIYDI IINNEIRGKK IVKSFETYTD KLMGQIKDLD
KIYNKFKSTN LFQIIIFLNK YHEINGKLDL TNYHHIIDQL IYYYRNFLSI YKNKYLVEFH
HQQFTYPRQF LTKLNRFLND ELYQFHQNER DRRINWLTKY GEFIPKQFKL PGDKQPSVVQ
VITEGLNDND DNEANGVFME KQLLDLIKSL M
//
