ID G3CEK6_9AMPH Unreviewed; 224 AA.
AC G3CEK6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE Flags: Fragment;
GN Name=BDNF {ECO:0000313|EMBL:AEB40267.1};
OS Liua tsinpaensis (Tsinpa salamander).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Caudata; Cryptobranchoidea; Hynobiidae; Liua.
OX NCBI_TaxID=245147 {ECO:0000313|EMBL:AEB40267.1};
RN [1] {ECO:0000313|EMBL:AEB40267.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21422243; DOI=10.1093/molbev/msr072;
RA Zheng Y., Peng R., Kuro-O M., Zeng X.;
RT "Exploring patterns and extent of bias in estimating divergence time from
RT mitochondrial DNA sequence data in a particular lineage: a case study of
RT salamanders (order caudata).";
RL Mol. Biol. Evol. 28:2521-2535(2011).
CC -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC located either in the central nervous system or directly connected to
CC it. {ECO:0000256|RuleBase:RU364086}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR EMBL; HM037752; AEB40267.1; -; Genomic_DNA.
DR AlphaFoldDB; G3CEK6; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01912; BDNFACTOR.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001789-1};
KW Growth factor {ECO:0000256|RuleBase:RU364086}.
FT DOMAIN 116..223
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT DISULFID 124..191
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 169..220
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 179..222
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEB40267.1"
FT NON_TER 224
FT /evidence="ECO:0000313|EMBL:AEB40267.1"
SQ SEQUENCE 224 AA; 25226 MW; D7133916552D828E CRC64;
AAPMKEASIR GQGSLAYPGL RTHGTLESIG GPKSSSRGGL TSLADTFEQV IEEMLEEEQS
MRPSEENKDA DLFTSRVMLS SQVPLEPPLL FLLEEYKNYL DAANMSMRVR RHSDPARRGE
LSVCDSISEW VTASDKKTAV DMSGQTVTVL EKVPVPKGQL KQYFYETKCN PMAYMKEGCR
GIDKRYWNSQ CRTTQSYVRA LTMDNKKKVG WRFIRIDTSC VCTL
//
