ID G3CKS6_EBVG Unreviewed; 609 AA.
AC G3CKS6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=BXLF1 {ECO:0000313|EMBL:AEM00657.1};
GN Name=BXLF1 {ECO:0000313|EMBL:AEM00657.1};
OS Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Gammaherpesvirinae; Lymphocryptovirus;
OC Lymphocryptovirus humangamma4.
OX NCBI_TaxID=10376 {ECO:0000313|EMBL:AEM00657.1, ECO:0000313|Proteomes:UP000163118};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AEM00657.1, ECO:0000313|Proteomes:UP000163118}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GD2 {ECO:0000313|EMBL:AEM00657.1};
RX PubMed=21880770; DOI=10.1128/JVI.00823-11;
RA Liu P., Fang X., Feng Z., Guo Y.M., Peng R.J., Liu T., Huang Z., Feng Y.,
RA Sun X., Xiong Z., Guo X., Pang S.S., Wang B., Lv X., Feng F.T., Li D.J.,
RA Chen L.Z., Feng Q.S., Huang W.L., Zeng M.S., Bei J.X., Zhang Y., Zeng Y.X.;
RT "Direct sequencing and characterization of a clinical isolate of epstein-
RT barr virus from nasopharyngeal carcinoma tissue by using next-generation
RT sequencing technology.";
RL J. Virol. 85:11291-11299(2011).
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DR EMBL; HQ020558; AEM00657.1; -; Genomic_DNA.
DR Proteomes; UP000163118; Genome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006230; P:TMP biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_04029; HSV_KITH; 1.
DR InterPro; IPR001889; Herpes_TK.
DR InterPro; IPR013672; Herpes_TK_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10513; DEOXYNUCLEOSIDE KINASE; 1.
DR PANTHER; PTHR10513:SF35; THYMIDINE KINASE 2, MITOCHONDRIAL; 1.
DR Pfam; PF00693; Herpes_TK; 1.
DR Pfam; PF08465; Herpes_TK_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA synthesis {ECO:0000256|ARBA:ARBA00022634};
KW Early protein {ECO:0000256|ARBA:ARBA00022518};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 564..596
FT /note="Herpesvirus thymidine kinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08465"
FT REGION 1..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 182..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..133
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..198
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 609 AA; 67331 MW; EE438E3598950FA1 CRC64;
MAGFPGKEAG PPGGWRKCQE DESPENERHE NFYAEIDDFA PSVLTPTGSD SGAGEEDDDG
LYQVPTHWPP LMAPTGLSGE RVPCRTQAAV TSNTGNSPGS RHTSCPFTLP RGAQPPAPAH
QKPTAPAPTP KPRSRECGPS KTPDPFSWFR KTSCTEGGAD STSRSFMYQK GFEEGLAGLG
LDDKSDCESE DESNFRRPSS HSALKQKNGG KGKPSGLFEH LAAHGREFSK LSKHAAQLKR
LSGSVMNVLN LDDAQDTRQA KAQRKESTRV PIVTHLTNHV PVIKPACSLF LEGAPGVGKT
TMLNHLKAVF GDLTIVVPEP MRYWTHVYEN AIKAMHKNVT RARHGREDTS AEVLACQMKF
TTPFRVLASR KRSLLVTESG ARSVAPLDCW ILHDRHLLSA SVVFPLMLLR SQLLSYSDFI
QVLATFTADP GDTIVWMKLN VEENMRRLKK RGRKHESGLD AGYLKSVNDA YHAVYCAWLL
TQYFAPEDIV KVCAGLTTIT TVCHQSHTPI IRSGVAEKLY KNSIFSVLKE VIQPFRADAV
LLEVCLAFTR TLAYLQFVLV DLSEFQDDLP GCWTEIYMQA LKNPAIRSQF FDWAGLSKVI
SDFERGNRD
//
