ID G3F0V9_HELPX Unreviewed; 152 AA.
AC G3F0V9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 13-SEP-2023, entry version 41.
DE RecName: Full=indole-3-glycerol-phosphate synthase {ECO:0000256|ARBA:ARBA00012362};
DE EC=4.1.1.48 {ECO:0000256|ARBA:ARBA00012362};
DE Flags: Fragment;
GN Name=trpC {ECO:0000313|EMBL:AEM67702.1};
OS Helicobacter pylori (Campylobacter pylori).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=210 {ECO:0000313|EMBL:AEM67702.1};
RN [1] {ECO:0000313|EMBL:AEM67702.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CAM125 {ECO:0000313|EMBL:AEM67702.1};
RX PubMed=21818291; DOI=10.1371/journal.pone.0022058;
RA Breurec S., Guillard B., Hem S., Brisse S., Dieye F.B., Huerre M., Oung C.,
RA Raymond J., Sreng Tan T., Thiberge J.M., Vong S., Monchy D., Linz B.;
RT "Evolutionary History of Helicobacter pylori Sequences Reflect Past Human
RT Migrations in Southeast Asia.";
RL PLoS ONE 6:E22058-E22058(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001633};
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 4/5. {ECO:0000256|ARBA:ARBA00004696}.
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DR EMBL; JF433617; AEM67702.1; -; Genomic_DNA.
DR AlphaFoldDB; G3F0V9; -.
DR UniPathway; UPA00035; UER00043.
DR GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00331; IGPS; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR PANTHER; PTHR22854:SF2; INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE; 1.
DR PANTHER; PTHR22854; TRYPTOPHAN BIOSYNTHESIS PROTEIN; 1.
DR Pfam; PF00218; IGPS; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW Isomerase {ECO:0000313|EMBL:AEM67702.1};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Tryptophan biosynthesis {ECO:0000256|ARBA:ARBA00022822}.
FT DOMAIN 1..152
FT /note="Indole-3-glycerol phosphate synthase"
FT /evidence="ECO:0000259|Pfam:PF00218"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEM67702.1"
FT NON_TER 152
FT /evidence="ECO:0000313|EMBL:AEM67702.1"
SQ SEQUENCE 152 AA; 17073 MW; FC1D46306CEE5BF2 CRC64;
CVSVLADSKY FLGSYENIKI VSQYSTKPVL CKDFIIDAFQ IKLARMMGAN AVLLMLSVLD
DKNYLELFNL AKSLNMSVLT EVSNQQEIKR LLKLQYDIIG INNRDLHTLT TDINNTLKLR
SLLPKDALVV SESGIYSHAQ IKALAPYVNG FL
//
