UniProt: G3GMG0

Database: UniProt
Entry: G3GMG0_CARAU

LinkDB:  G3GMG0_CARAU 
Original site:  G3GMG0_CARAU

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Ontology (8)   
   GO (8)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (16)   
   InterPro (7)   
   Pfam (4)   
   PROSITE (3)   
   SMART (2)   
Literature (1)   
   PubMed (1)   
All databases (27)   

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ID   G3GMG0_CARAU            Unreviewed;       680 AA.
AC   G3GMG0;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
OS   Carassius auratus (Goldfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Carassius.
OX   NCBI_TaxID=7957 {ECO:0000313|EMBL:AEN04474.1};
RN   [1] {ECO:0000313|EMBL:AEN04474.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=21795596; DOI=10.4049/jimmunol.1100642;
RA   Sun F., Zhang Y.B., Liu T.K., Shi J., Wang B., Gui J.F.;
RT   "Fish MITA serves as a mediator for distinct fish IFN gene activation
RT   dependent on IRF3 or IRF7.";
RL   J. Immunol. 187:2531-2539(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00029316};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066;
CC         Evidence={ECO:0000256|ARBA:ARBA00029316};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the helicase family. RLR subfamily.
CC       {ECO:0000256|ARBA:ARBA00006866}.
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DR   EMBL; JF970227; AEN04474.1; -; mRNA.
DR   AlphaFoldDB; G3GMG0; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   CDD; cd12090; MDA5_ID; 1.
DR   Gene3D; 1.20.1320.30; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   Gene3D; 2.170.150.30; RIG-I-like receptor, C-terminal regulatory domain; 1.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR041204; RIG-I-like_C.
DR   InterPro; IPR038557; RLR_C_sf.
DR   InterPro; IPR021673; RLR_CTR.
DR   PANTHER; PTHR14074:SF7; ATP-DEPENDENT RNA HELICASE DHX58; 1.
DR   PANTHER; PTHR14074; HELICASE WITH DEATH DOMAIN-RELATED; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   Pfam; PF18119; RIG-I_C; 1.
DR   Pfam; PF11648; RIG-I_C-RD; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51789; RLR_CTR; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:AEN04474.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          13..191
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          356..515
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   DOMAIN          543..670
FT                   /note="RLR CTR"
FT                   /evidence="ECO:0000259|PROSITE:PS51789"
SQ   SEQUENCE   680 AA;  77833 MW;  7F78F3560E559318 CRC64;
     MEITLRSYQE EVVQAALKGE NSIIWLPTGG GKTRAAVYVA KKHLETTRNA KVAVLVNKVH
     LVDQHFNNEF NPYLGKAYRV KAISGDSSDK DLFGRLVKDS DLIICTAQIL ENALNSSEEE
     KHVELTDFSL LIIDECHHTQ KESVYNKIMG RYVEKKVRKE RKLPQVLGLT ASPGTGGNKT
     LAKAVEHVLQ ICANLDSVIV STKNYASKLK EVVPRPRKQY DIVEKRALDP FGDHLKLMMS
     LIHEFMPSTV SRSLREVGTQ DYEADVVELE KTGVKEENRL ITQCALHLRQ YNDALLIHDT
     VRMVDAFNVL DEFYNSRSNK LLDGTDFFLQ GLFDENRVEL KQLALDARYE NPKLAQLQRT
     LLKEFKENKM SRGIIFSKTR RGTHCLYDWV NANHELQKVK ISAGILTGTG TGVNHMNQNK
     QKNTIKDFRL GHLNLLISTS VAEEGLDIAE CNLVVRYGLL TNEIAQQQAS GRARALNSVY
     SVVAEEGGRE LRREFTNEYL ESLTSNAIDQ VQSMSPREFR IKITELRQMA VLIRIEAERK
     KDARKQRYSP DQVHLQCRGC FVFVGLGEDI RKIENSHHVN INPEFQRHYR TGKQVFLEKT
     FEDWEPGQVI NCRKCGKDWG MEIKFKKVAI LPCLNIKSFS LDTPGGKFTH KQWKDVEFQV
     TEFDFIDYMS SRFPDLDLDD
//

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