ID   G3GTU9_CRIGR            Unreviewed;       884 AA.
AC   G3GTU9;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   RecName: Full=Protein unc-45 homolog B {ECO:0000256|ARBA:ARBA00020768};
GN   ORFNames=I79_001088 {ECO:0000313|EMBL:EGV94394.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV94394.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA   Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA   Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA   Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL   Nat. Biotechnol. 29:735-741(2011).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, A band
CC       {ECO:0000256|ARBA:ARBA00004161}. Cytoplasm, myofibril, sarcomere, Z
CC       line {ECO:0000256|ARBA:ARBA00004216}. Cytoplasm, perinuclear region
CC       {ECO:0000256|ARBA:ARBA00004556}.
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DR   EMBL; JH000022; EGV94394.1; -; Genomic_DNA.
DR   AlphaFoldDB; G3GTU9; -.
DR   STRING; 10029.G3GTU9; -.
DR   PaxDb; 10029-XP_003495851-1; -.
DR   eggNOG; KOG4151; Eukaryota.
DR   InParanoid; G3GTU9; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0031672; C:A band; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR024660; UCS_central_dom.
DR   PANTHER; PTHR45994; FI21225P1; 1.
DR   PANTHER; PTHR45994:SF2; PROTEIN UNC-45 HOMOLOG B; 1.
DR   Pfam; PF11701; UNC45-central; 1.
DR   SMART; SM00185; ARM; 3.
DR   SUPFAM; SSF48371; ARM repeat; 2.
DR   SUPFAM; SSF48452; TPR-like; 1.
PE   4: Predicted;
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   Myogenesis {ECO:0000256|ARBA:ARBA00022541};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT   DOMAIN          262..442
FT                   /note="UNC-45/Cro1/She4 central"
FT                   /evidence="ECO:0000259|Pfam:PF11701"
SQ   SEQUENCE   884 AA;  98336 MW;  CFD9C3264B5270BB CRC64;
     MESLIPVPQE SYAQAASDAS RAIDINSTDI KALYRRCQAL EHLGKLDQAF KDVQRCATLE
     PRNQNFQETL RRLNTSIQEQ LRAQFSTDSR VQTMFEILLN ENSEADKREK AANNLIVLGR
     EEAGAERIFQ SNGVGLLLQL MDTKRPELVL AAVRTLSGMC SGHQARATAI LHTVRTDRIC
     SLMATENEEM SLAVCNLLQA IIDSLSGEDK REHRGKEEAL VLDTKKDLKQ ITSHLLDMLV
     SKKVSGQGRD QALNLLNKNV PRKDLSIHDN SRTIYVVDNG LRKILKVVGQ VPDLPSCLPL
     TDNTRMLASI LINKLYDDLR CDPERDHFRK ICEEYITGKF DPQDMDKNVN AIQTVSGILQ
     GPFDLGNQLL GMKGVMEMMV ALCGSEREAD QLVAVEALIH ASTKLSRATF IITNGVSLLK
     QIYKTTKNEK IKIRTLVGLC KLGSAGGSDY GLRQFAEGST EKLAKQCRKW LCNTAIDTRT
     RRWAVEGLAY LTLDADVKDD FVQDIPALQA MFELAKARTS DKTILYSVAN TLVNCTNSYD
     VKEVVPELVQ LAKFSKQHVP EEHPKDKKDF VDMRVKRLLK AGVISALACM VKADSAILTD
     QTKELLARVF LALCDNPKDR GTIVAQGGGK ALIPLALEGT DVGKVKAAHG LAKIAAVSNP
     DIAFPGERVY EVVRPLVSLL DTQRDGLQNY EALLGLTNLS GRSDKLRQKI FKEKALPDIE
     NYMFENHDQL RQAATECMCN MVINKEVQER FLADGNDRLK LVVLLCGEED DKLQNAAAGA
     LAMLTAAHKK LCLKMTQVTT QWLEILQRLC LHDQLSVQHR GLVIAYNLLS ADAELARKLV
     ESELLEILTV VGKQEPDEKR ATVVQTAREC LIKCMDYGFI KPVS
//