ID G3H6R2_CRIGR Unreviewed; 474 AA.
AC G3H6R2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE SubName: Full=Equilibrative nucleoside transporter 3 {ECO:0000313|EMBL:EGV93760.1};
DE SubName: Full=Solute carrier family 29 member 3 {ECO:0000313|Ensembl:ENSCGRP00001026663.1};
GN Name=Slc29a3 {ECO:0000313|Ensembl:ENSCGRP00001026663.1};
GN ORFNames=I79_006030 {ECO:0000313|EMBL:EGV93760.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV93760.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGV93760.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSCGRP00001026663.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004424}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
CC {ECO:0000256|ARBA:ARBA00007965}.
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DR EMBL; JH000180; EGV93760.1; -; Genomic_DNA.
DR RefSeq; XP_003499946.2; XM_003499898.3.
DR RefSeq; XP_007611765.1; XM_007613575.2.
DR STRING; 10029.G3H6R2; -.
DR PaxDb; 10029-XP_007611765-1; -.
DR Ensembl; ENSCGRT00001030909.1; ENSCGRP00001026663.1; ENSCGRG00001023912.1.
DR GeneID; 100767453; -.
DR CTD; 55315; -.
DR eggNOG; KOG1479; Eukaryota.
DR GeneTree; ENSGT00950000182898; -.
DR OMA; GSPWTTK; -.
DR OrthoDB; 517168at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP000694386; Unplaced.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0031902; C:late endosome membrane; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR GO; GO:0015212; F:cytidine transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015208; F:guanine transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0008504; F:monoamine transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0005326; F:neurotransmitter transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015101; F:organic cation transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015210; F:uracil transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015213; F:uridine transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0032238; P:adenosine transport; IEA:Ensembl.
DR GO; GO:0015872; P:dopamine transport; IEA:Ensembl.
DR GO; GO:0035340; P:inosine transport; IEA:Ensembl.
DR GO; GO:0015874; P:norepinephrine transport; IEA:Ensembl.
DR GO; GO:0006837; P:serotonin transport; IEA:Ensembl.
DR InterPro; IPR002259; Eqnu_transpt.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR10332; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; 1.
DR PANTHER; PTHR10332:SF17; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 3; 1.
DR Pfam; PF01733; Nucleoside_tran; 1.
DR PIRSF; PIRSF016379; ENT; 1.
DR PRINTS; PR01130; DERENTRNSPRT.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 53..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 132..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 199..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 377..394
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 414..435
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 447..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 474 AA; 51214 MW; 88C9EFD9B0629EBB CRC64;
MADSEDNIYQ SSNATYGALS NPHNADQEAL LGKLLDYPAP GLQRPEDRFN GTYIIFFSLG
IGGLLPWNFF VTAKEYWAFK LRNCSSLASG KDSEDTDILN YFESYLAVAS TVPSLLCLVA
NFLLVNRVQV HVRVLASLSV SLAIFVVMIV LVKVDTSSWT RGFFSVTIAC MAIVSGSSTI
FNSSVYGLTG SFPMRNAQAL ISGGAMGGTV SAVASLVDLA ASSDVRDSAL AFFLTAAVFL
GLCAGFYLLL SRLEYARYYM RPVVPVHVFS GEEHPSQDTP STSSVAPGSR VVHTPPLGPI
LKKTAGLGFC TVFIYFITAL IFPAISTNIQ SMHKGTGSPW TAKFFVPLTV FLLFNFADLC
GRQVTAWIQV PGPRSKVLPA LALLRVCLVP LFLLCNYQPR SHLTVVLFQS DIYPVLFTCL
LGLSNGYLST LVLIYGPKIV PRELAEATGV VMSFYMSVGL MLGSACAALL VHLI
//
