ID G3H7D9_CRIGR Unreviewed; 475 AA.
AC G3H7D9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Centrosomal protein of 57 kDa {ECO:0000313|EMBL:EGW00888.1};
GN ORFNames=I79_006270 {ECO:0000313|EMBL:EGW00888.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW00888.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
CC -!- SIMILARITY: Belongs to the translokin family.
CC {ECO:0000256|ARBA:ARBA00008179}.
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DR EMBL; JH000193; EGW00888.1; -; Genomic_DNA.
DR AlphaFoldDB; G3H7D9; -.
DR STRING; 10029.G3H7D9; -.
DR PaxDb; 10029-XP_007631647-1; -.
DR eggNOG; ENOG502QTZR; Eukaryota.
DR InParanoid; G3H7D9; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR Gene3D; 1.20.58.90; -; 1.
DR InterPro; IPR025913; Cep57_CLD.
DR InterPro; IPR024957; Cep57_MT-bd_dom.
DR PANTHER; PTHR19336:SF11; CENTROSOMAL PROTEIN OF 57 KDA; 1.
DR PANTHER; PTHR19336; UNCHARACTERIZED DUF1167; 1.
DR Pfam; PF14073; Cep57_CLD; 1.
DR Pfam; PF06657; Cep57_MT_bd; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT DOMAIN 41..217
FT /note="Cep57 centrosome localisation"
FT /evidence="ECO:0000259|Pfam:PF14073"
FT DOMAIN 326..394
FT /note="Cep57 centrosome microtubule-binding"
FT /evidence="ECO:0000259|Pfam:PF06657"
FT REGION 230..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 39..210
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 400..422
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..452
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 475 AA; 54715 MW; 7FD1AD289ACF81DD CRC64;
MIRHSPSPYV LYPSDKPFLN SDLRRSPNKP TFAYPESNSR AIFSALKNLQ EKIRRLELER
IQAEESVKTL SRETIEYKKV LDEQIQEREN SKNEESKHNQ ELTSQLLAAE NKCNLLEKQL
EYMRNMIKHA EMERTSVLEK QVSLEKERQH DQNHVQSQLE KLDLLEQEYS KLTTMQVLAE
KKMQELESKL HEEEQERKRM QAQAAELQTG LEANRLIFED KTTSSYVATN TRKIKKKKSK
PPEKKGPRNY FGAQPHYRLC LGDMPFVAGK STSPSHAVVA NVQHVLHLMK HHSKALCNDR
VVNSVPLAKQ ACSRGCRSSK KSVTPPSGSV SEELSDVLET LQDEFGQMSF DHQQLAKLIQ
ESPTVELKDN LECELEALVG RMEAKANQIT KVRKYQAQLE KQNIDKQKKE LKPNKKTLDE
EGNSSNRSPG VTRTTSKKDF AKQRPGEKSR KNLQLLKDMQ TIQNSLQSSN LCWDY
//
