ID   G3H8Q6_CRIGR            Unreviewed;       497 AA.
AC   G3H8Q6;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
GN   ORFNames=I79_006766 {ECO:0000313|EMBL:EGW04614.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW04614.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA   Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA   Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA   Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL   Nat. Biotechnol. 29:735-741(2011).
CC   -!- FUNCTION: Functions in nuclear protein import.
CC       {ECO:0000256|PIRNR:PIRNR005673}.
CC   -!- SIMILARITY: Belongs to the importin alpha family.
CC       {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
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DR   EMBL; JH000218; EGW04614.1; -; Genomic_DNA.
DR   RefSeq; XP_003500546.1; XM_003500498.2.
DR   RefSeq; XP_007633382.1; XM_007635192.1.
DR   AlphaFoldDB; G3H8Q6; -.
DR   STRING; 10029.G3H8Q6; -.
DR   PaxDb; 10029-XP_007633382-1; -.
DR   GeneID; 100761838; -.
DR   CTD; 3839; -.
DR   eggNOG; KOG0166; Eukaryota.
DR   InParanoid; G3H8Q6; -.
DR   OMA; GGNEHIQ; -.
DR   OrthoDB; 916229at2759; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR032413; Arm_3.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR002652; Importin-a_IBB.
DR   InterPro; IPR036975; Importin-a_IBB_sf.
DR   InterPro; IPR024931; Importin_alpha.
DR   PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR   PANTHER; PTHR23316:SF6; IMPORTIN SUBUNIT ALPHA-4; 1.
DR   Pfam; PF00514; Arm; 8.
DR   Pfam; PF16186; Arm_3; 1.
DR   Pfam; PF01749; IBB; 1.
DR   PIRSF; PIRSF005673; Importin_alpha; 1.
DR   SMART; SM00185; ARM; 8.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 3.
DR   PROSITE; PS51214; IBB; 1.
PE   3: Inferred from homology;
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW   ECO:0000256|PIRNR:PIRNR005673};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT   DOMAIN          1..34
FT                   /note="IBB"
FT                   /evidence="ECO:0000259|PROSITE:PS51214"
FT   REPEAT          90..134
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REPEAT          133..160
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REPEAT          260..298
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
SQ   SEQUENCE   497 AA;  55024 MW;  D9011CF56057F070 CRC64;
     MRRHRNEVTV ELRKNKRDEH LLKKRNVPQE ESLEDSDVDA DFKAQNVTLE AILQNATSDN
     PVVQLSAVQA ARKLLSSDRN PPIDDLIKSG ILPILVKCLE RDDNPSLQFE AAWALTNIAS
     GTSAQTQAVV QSNAVPLFLR LLHSTHQNVC EQAVWALGNI IGDGPQCRDY VISLGVVKPL
     LSFINPSIPI TFLRNVTWVI VNLCRNKDPP PPMETVQEIL PALCVLIYHT DINILVDTVW
     ALSYLTDGGN EQIQMVIDSG VVPFLVPLLS HQEVKVQTAA LRAVGNIVTG TDEQTQVVLN
     CDVLSHFPNL LSHPKEKINK EAVWFLSNIT AGNQQQVQAV IDAGLIPMII HQLAKGDFGT
     QKEAAWAISN LTISGRKDQV EYLVQQNVIP PFCNLLSVKD SQVVQVVLDG LKNILIMAGD
     EASTIAEIIE ECGGLEKIEV LQQHENEDIY KLAFEIIDQY FSGDDIDEDP SLIPEATQGG
     TYNFDPTANL QTKEFNF
//