ID G3H8V3_CRIGR Unreviewed; 826 AA.
AC G3H8V3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=PDX1 C-terminal inhibiting factor 1 {ECO:0000313|Ensembl:ENSCGRP00001007107.1};
DE SubName: Full=Phosphorylated CTD-interacting factor 1 {ECO:0000313|EMBL:EGV97684.1};
DE SubName: Full=mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase isoform X1 {ECO:0000313|RefSeq:XP_027279231.1};
GN Name=Pcif1 {ECO:0000313|Ensembl:ENSCGRP00001007107.1,
GN ECO:0000313|RefSeq:XP_027279231.1};
GN ORFNames=I79_006814 {ECO:0000313|EMBL:EGV97684.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV97684.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGV97684.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSCGRP00001007107.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:XP_027279231.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027279231.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_027279231.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; JH000219; EGV97684.1; -; Genomic_DNA.
DR RefSeq; XP_003500578.2; XM_003500530.2.
DR RefSeq; XP_027279231.1; XM_027423430.2.
DR STRING; 10029.G3H8V3; -.
DR PaxDb; 10029-XP_007608540-1; -.
DR Ensembl; ENSCGRT00001011117.1; ENSCGRP00001007107.1; ENSCGRG00001009568.1.
DR GeneID; 100771480; -.
DR KEGG; cge:100771480; -.
DR CTD; 63935; -.
DR eggNOG; ENOG502QVT7; Eukaryota.
DR GeneTree; ENSGT00390000016206; -.
DR OrthoDB; 5472126at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP000694386; Unplaced.
DR Proteomes; UP001108280; Chromosome 6.
DR GO; GO:0045171; C:intercellular bridge; IEA:Ensembl.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0016422; F:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity; IEA:Ensembl.
DR GO; GO:1990269; F:RNA polymerase II C-terminal domain phosphoserine binding; IEA:Ensembl.
DR GO; GO:1904047; F:S-adenosyl-L-methionine binding; IEA:Ensembl.
DR GO; GO:0017148; P:negative regulation of translation; IEA:Ensembl.
DR GO; GO:0045727; P:positive regulation of translation; IEA:Ensembl.
DR CDD; cd00201; WW; 1.
DR Gene3D; 1.20.1270.10; -; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR InterPro; IPR029048; HSP70_C_sf.
DR InterPro; IPR039881; PCIF1-like.
DR InterPro; IPR022035; PCIF1_WW.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR21727:SF0; MRNA (2'-O-METHYLADENOSINE-N(6)-)-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR21727; PHOSPHORYLATED CTD INTERACTING FACTOR 1; 1.
DR Pfam; PF12237; PCIF1_WW; 1.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT DOMAIN 166..200
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 103..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 788..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 788..807
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 808..826
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 826 AA; 93998 MW; AE3EA3EB7B8B0204 CRC64;
MAARPRRGPS EAVPTHAQRG VPARDTRWRQ RRWGGRGGGG KTGGRAERVA ASPRVRFGQL
LMHGVPCVPV NYTADQPTFL CYTFLWASPL LLWDPVTWVQ SSQRRKPSHA SVADPRGSRV
AAEMANENHG SPREEASLLS HSPGTSNQSQ PCSPKPVRLV QDLPEELVHA GWEKCWSRRE
SRPYYFNRFT NQSLWEMPVL GQHDVLSDPL GLNATPLPQD SSLVETPPVE NKPRKRQLSE
EQPSGNGVKK PKIEIPVTPT SQSVPSSPSI PGTPTLKIWG GSAEDKQQAA LLRPTEVYWD
LDIQTNAVIK HRGPSEVLPP HPEVELLRSQ LILKLRQHYR ELCQQREGIE PPRESFNRWM
LERKVVDKGS DPLLPSNCDP VVSPSMFREI MNDIPIRLSR IKFREEAKRL LFKYAEAARR
LIESRSASPD SRKVVKWNVE DTFSWLRKDH SASKEDYMDR LEHLRRQCGP HVSAAAKDSV
EGICSKIYHI SLEYVKRIRE KHLAILKENN IPEEVEASEL EPRLVYCYPV RLAVSAPPMP
SVEMHMENSV VCIRYKGEMV KVSRSYFSKL WLLYRYSCVD DSAFERFLPR VWCLLRRYQM
MFGVGLYEGT GLQGSLPVHV FEVLHRLFGV SFECFASPLN CYFRQYCSAF PDTDGYFGSR
GPCLDFAPLS GSFEANPPFC EELMDAMVSH FEKLLESSPE PLSFIVFIPE WREPPTPALT
RMEQSRFKRH QLVLPAFEHE YRSGSQHICK KEEMHYKAVH NTAVLFLQND PGFAKWGPTP
ERLQELTTAY KQSGRSHGSS SSSSSSEAKD RDSGREQGPS REPHPT
//
