ID   G3HBS2_CRIGR            Unreviewed;       436 AA.
AC   G3HBS2;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   SubName: Full=Regulator of G-protein signaling 11 {ECO:0000313|EMBL:EGW04359.1};
GN   ORFNames=I79_007871 {ECO:0000313|EMBL:EGW04359.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW04359.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA   Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA   Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA   Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL   Nat. Biotechnol. 29:735-741(2011).
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DR   EMBL; JH000273; EGW04359.1; -; Genomic_DNA.
DR   AlphaFoldDB; G3HBS2; -.
DR   STRING; 10029.G3HBS2; -.
DR   PaxDb; 10029-XP_007606733-1; -.
DR   eggNOG; KOG3589; Eukaryota.
DR   InParanoid; G3HBS2; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   CDD; cd04450; DEP_RGS7-like; 1.
DR   CDD; cd00068; GGL; 1.
DR   Gene3D; 1.10.1240.60; -; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR015898; G-protein_gamma-like_dom.
DR   InterPro; IPR036284; GGL_sf.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR047016; RGS6/7/9/11.
DR   InterPro; IPR047017; RGS6/7/9/11_DHEX_sf.
DR   InterPro; IPR040759; RGS_DHEX.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR45746; LP21163P; 1.
DR   PANTHER; PTHR45746:SF3; REGULATOR OF G-PROTEIN SIGNALING 11; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF00631; G-gamma; 1.
DR   Pfam; PF00615; RGS; 1.
DR   Pfam; PF18148; RGS_DHEX; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00049; DEP; 1.
DR   SMART; SM01224; G_gamma; 1.
DR   SMART; SM00224; GGL; 1.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   SUPFAM; SSF48670; Transducin (heterotrimeric G protein), gamma chain; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50186; DEP; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700}.
FT   DOMAIN          34..109
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   DOMAIN          272..387
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
SQ   SEQUENCE   436 AA;  50040 MW;  472A4199B0EB15BB CRC64;
     MATAAGCTPH GGCSRTQWSH LSKMERMVMS MQDPDQGVKM RSQRLLITVI PHAVAGKDVV
     EWLVQKFCIS EEEALHLGTL LAQYGYIYPL RESRDLTLRP DETPYRFQTP YFWTSTLWPA
     SELDYAIYLA KKNIQKQGVL VDYEKEHYAQ LHKKINHAWD LVVMQAREQL RAAKQRRKGD
     RLVISCQEQT YWLVNKPPIQ CFRKALGRNR VKSSVCLEAY LKFSSQHGPH DPIMSGCLPS
     NPWITDDVTY WTMNAPMVTA PTKLRVERWS FSFRELLDDP MGRGHFMDFL QKEFSAENLS
     FWEACEELRF GGQAQVPALV DAVYQQFLAP GAARWINIDS RTMECTLEGL RQPHRYVLDA
     AQLHIYMLMK KDSYPRFLKS DIYKGLLEEA VTPLETKRRS VGCQLHAVVL TVVLPDPVGQ
     VFGKEQSPCP GCPLCC
//