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Database: UniProt
Entry: G3HCZ0_CRIGR
LinkDB: G3HCZ0_CRIGR
Original site: G3HCZ0_CRIGR 
ID   G3HCZ0_CRIGR            Unreviewed;      1774 AA.
AC   G3HCZ0;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   25-OCT-2017, entry version 31.
DE   RecName: Full=Voltage-dependent P/Q-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   ORFNames=I79_008358 {ECO:0000313|EMBL:EGW00626.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW00626.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
RA   Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
RA   Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
RA   Quake S.R., Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell
RT   line.";
RL   Nat. Biotechnol. 29:735-741(2011).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1A
CC       gives rise to P and/or Q-type calcium currents. P/Q-type calcium
CC       channels belong to the 'high-voltage activated' (HVA) group and
CC       are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-
CC       IVA (omega-Aga-IVA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; JH000286; EGW00626.1; -; Genomic_DNA.
DR   InParanoid; G3HCZ0; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR005448; CACNA1A.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01632; PQVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001075};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    101    120       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    212    234       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    362    381       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    393    413       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    488    510       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    564    588       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    841    860       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    880    901       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    913    930       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    975    997       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1087   1112       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1160   1178       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1190   1213       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1281   1299       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1377   1401       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1538   1572       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      584    620       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1774 AA;  200885 MW;  DE3A611DF3B6FCE9 CRC64;
     MPAERAGAPS QGRVASSIHA GEACGSFAYQ QADVYNPDEQ ETAMLPGRTL AMLELILATV
     GTEFDLRTLR AVRVLRPLKL VSGIPSLQVV LKSIMKAMIP LLQIGLLLFF AILIFAIIGL
     EFYMGKFHTT CFEEGTDDIQ GESPAPCGTE EPARTCPNGT KCQPYWEGPN NGITQFDNIL
     FAVLTVFQCI TMEGWTDLLY NSNDASGNTW NWLYFIPLII IGSFFMLNLV LGVLSGEFAK
     ERERVENRRA FLKLRRQQQI ERELNGYMEW ISKAEEVILA EDETDVEQRH PFDALRRATL
     KKSKTDLLNP EEAEDQLADI ASVGSPFARA SIKSAKLENS TFFHKKERRM RFYIRRMVKT
     QAFYWTVLSL VALNTLCVAI VHYNQPEWLS DFLYYAEFIF LGLFMSEMFI KMYGLGTRPY
     FHSSFNCFDC GVIIGSIFEV IWAVIKPGTS FGISVLRALR LLRIFKVTKY WASLRNLVVS
     LLNSMKSIIS LLFLLFLFIV VFALLGMQLF GGQFNFDEGT PPTNFDTFPA AIMTVFQILT
     GEDWNEVMYD GIKSQGGVQG GMVFSIYFIV LTLFGNYTLL NVFLAIAVDN LANAQELTKD
     EQEEEEAANQ KLALQKAKEV AEVSPLSAAN MSIAVENQGS GIPMSGPNLS TTRPIQQDLG
     RQDLPLAEDL DNMKNNKLAT GEPASPHDSL GHSGLPPSPT KIGNSTNPGP TLATNPQNAA
     SRRMPNNPGN PSNPGPPKTP ENSLIVTNPS STQPNSAKTA RKPEHMAVEI PPACPPLNHT
     VVQVNKNANP DPLPKKEEEK KEEEEADPGE DGPKPMPPYS SMFILSTTNP LRRLCHYILN
     LRYFEMCILM VIAMSSIALA AEDPVQPNAP RNNVLRYFDY VFTGVFTFEM VIKMIDLGLV
     LHQGAYFRDL WNILDFIVVS GALVAFAFTG NSKGKDINTI KSLRVLRVLR PLKTIKRLPK
     LKAVFDCVVN SLKNVFNILI VYMLFMFIFA VVAVQLFKGK FFHCTDESKE FERDCRGKYL
     LYEKNEVKAR DREWKKYEFH YDNVLWALLT LFTVSTGEGW PQVLKHSVDA TFENQGPSPG
     YRMEMSIFYV VYFVVFPFFF VNIFVALIII TFQEQGDKMM EEACIDFAIS AKPLTRHMPQ
     NKQSFQYRMW QFVVSPPFEY TIMAMIALNT IVLMMKFYGA SVAYENALRV FNIVFTSLFS
     LECVLKVMAF GILNYFRDAW NIFDFVTVLG SITDILVTEF GNNFINLSFL RLFRAARLIK
     LLRQGYTIRI LLWTFVQSFK ALPYVCLLIA MLFFIYAIIG MQVFGNIGID GEDEDSDEDE
     FQITEHNNFR TFFQALMLLF RSATGEAWHN IMLSCLSGKP CDKNSGILTA DCGNEFAYFY
     FVSFIFLCSF LMLNLFVAVI MDNFEYLTRD SSILGPHHLD EYVRVWAEYD PAAWGRMPYP
     DMYQMLRHMS PPLGLGKKCP ARVAYKRLLR MDLPVADDNT VHFNSTLMAL IRTALDIKIA
     KGGADKQQMD AELRKEMMAI WPNLSQKTLD LLVTPHKSTD LTVGKIYAAM MIMEYYRQSK
     AKKLQAMREE QNRTPLMFQR MEPPSPTQEG GPSQNALPST QLDPGGGLMA QESSMKESPS
     WVTQRAQEMF QKTGTWSPER GPPSDMPNSQ PNSQSVEMRE MGTDGYSDSE HYLPMEGQAR
     AASMPRLPAE NQTISDTSPM KRSASVLGPK ARRLDDYSLE RVPPEENQRY HQRRRDRGHR
     TSERSLGRYT DVDTGPSPPP CLFGKYFCEY GLYL
//
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