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Database: UniProt
Entry: G3HEJ3_CRIGR
LinkDB: G3HEJ3_CRIGR
Original site: G3HEJ3_CRIGR 
ID   G3HEJ3_CRIGR            Unreviewed;      1033 AA.
AC   G3HEJ3;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   25-OCT-2017, entry version 34.
DE   SubName: Full=Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 {ECO:0000313|EMBL:EGW02119.1};
GN   ORFNames=I79_008977 {ECO:0000313|EMBL:EGW02119.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW02119.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
RA   Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
RA   Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
RA   Quake S.R., Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell
RT   line.";
RL   Nat. Biotechnol. 29:735-741(2011).
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DR   EMBL; JH000315; EGW02119.1; -; Genomic_DNA.
DR   InParanoid; G3HEJ3; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030552; F:cAMP binding; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   GO; GO:0002027; P:regulation of heart rate; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR018488; cNMP-bd_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR030173; HCN4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR10217:SF375; PTHR10217:SF375; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS00888; CNMP_BINDING_1; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001075};
KW   Ion channel {ECO:0000256|SAAS:SAAS00904115};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00903208};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00904256};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00903350};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00903851}.
FT   TRANSMEM    101    121       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    328    351       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      429    544       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
SQ   SEQUENCE   1033 AA;  111865 MW;  CE415854A22B5C79 CRC64;
     MVLNTILGSV QRFVQPSGKE YRDTVYKAKG SSQSLNLLIF SSSIFPLSPI MVTNSHLFGY
     PAAGDGFLDP KATSPGGFSS LVHSLPVTGP FISLGRFYWD LTMLLLMVGN LIIIPVGITF
     FKDENTTPWI VFNVVSDTFF LIDLVLNFRT GIVVEDNTEI ILDPQRIKMK YLKSWFVVDF
     ISSIPVDYIF LIVETRIDSE VYKTARALRI VRFTKILSLL RLLRLSRLIR YIHQWEEIFH
     MTYDLASAVV RIVNLIGMML LLCHWDGCLQ FLVPMLQDFP HDCWVSINGM VNNSWGKQYS
     YALFKAMSHM LCIGYGRQAP VGMSDVWLTM LSMIVGATCY AMFIGHATAL IQSLDSSRRQ
     YQEKYKQVEQ YMSFHKLPPD TRQRIHDYYE HRYQGKMFDE ESILGELSEP LREEIINFNC
     RKLVASMPLF ANADPNFVTS MLTKLRFEVF QPGDYIIREG TIGKKMYFIQ HGVVSVLTKG
     NKETKLADGS YFGEICLLTR GRRTASVRAD TYCRLYSLSV DNFNEVLEEY PMMRRAFETV
     ALDRLDRIGK KNSILLHKVQ HDLNSGVFNY QENEIIQQIV RHDREMAHCA HRVQAAASAT
     PTPTPVIWTP LIQAPLQAAA ATTSVAIALT HHPRLPAAIF RPPPGPGLGN LGAGQTPRHP
     RRLQSLIPLV LGSVSPASSP SQVDTPSSSS FHIQQLAGFS APPGLSPLLP SSSSSPPPGA
     CGSPPAPTPS TSAAAATTAG FGHFHKALGG SLSSSDSPLL TPLQPGARSP QAAQLPPPLP
     GARGGLGLLE HFLPPPPSSR SPSSSPGQLG QPPGELSPGL AAGPPSTPET PPRPERPSFM
     AGASGGASPV AFTQRGGLSP PGHSPGPPRT FPSAPPRASG SHGSLLLPPA SSPPPPQVPQ
     RRGTPPLTPG RLTQDLKLIS ASQPALPQDG AQTLRRASPH SSGESVAAFP LFPRAVGGSG
     SSGGLGPPGR PYGAIPGQHV TLPRKTSSGS LPPPLSLFGA RAVSSGGPPL TAAPQREPGA
     RSEPVRSKLP SNL
//
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