ID G3HEW9_CRIGR Unreviewed; 311 AA.
AC G3HEW9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE SubName: Full=Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform {ECO:0000313|EMBL:EGV98741.1};
GN ORFNames=I79_009116 {ECO:0000313|EMBL:EGV98741.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV98741.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. {ECO:0000256|PROSITE-
CC ProRule:PRU00877}.
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DR EMBL; JH000322; EGV98741.1; -; Genomic_DNA.
DR AlphaFoldDB; G3HEW9; -.
DR STRING; 10029.G3HEW9; -.
DR eggNOG; KOG0904; Eukaryota.
DR InParanoid; G3HEW9; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.10.20.770; -; 2.
DR InterPro; IPR003113; PI3K_ABD.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR Pfam; PF02192; PI3K_p85B; 1.
DR SMART; SM00143; PI3K_p85B; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS51544; PI3K_ABD; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:EGV98741.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Transferase {ECO:0000313|EMBL:EGV98741.1}.
FT DOMAIN 16..105
FT /note="PI3K-ABD"
FT /evidence="ECO:0000259|PROSITE:PS51544"
SQ SEQUENCE 311 AA; 35682 MW; 6A09EFB5929702D2 CRC64;
MADILDIWAV DSQIASDGAI SVDFLLPTGI YIQLEVPREA TISYIKQMLW KHVHNYPMFN
LLMDIDSYMF ACVNQTAVYE ELEDETRRLC DVRPFLPVLK LVTRSCDPAE KLDSKIGVLI
GKGLHEFDAL KDPEVNEFRR KMRKFSEDKI QSLVGLSWID WLKHTYPPEH EASVLENLED
KLYGGKLIVA VHFENSQYIR NCVMNRTLPH FILVECCKIK KMYEQEMIAI EAAINRNSSN
LPLPLPPKKT RVISVRSPSH TLVNPKPCDF SVCKLALSDP LPLLTSPSVE INICQKFIAI
HLKRAFFYMA L
//
