ID G3HIB4_CRIGR Unreviewed; 486 AA.
AC G3HIB4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE SubName: Full=SHC-transforming protein 3 {ECO:0000313|EMBL:EGV98274.1};
GN ORFNames=I79_010382 {ECO:0000313|EMBL:EGV98274.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV98274.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
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DR EMBL; JH000401; EGV98274.1; -; Genomic_DNA.
DR AlphaFoldDB; G3HIB4; -.
DR STRING; 10029.G3HIB4; -.
DR PaxDb; 10029-XP_007635434-1; -.
DR InParanoid; G3HIB4; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01209; PTB_Shc; 1.
DR CDD; cd09925; SH2_SHC; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006019; PID_Shc-like.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035676; SHC_SH2.
DR PANTHER; PTHR10337; SHC TRANSFORMING PROTEIN; 1.
DR PANTHER; PTHR10337:SF4; SHC-TRANSFORMING PROTEIN 3; 1.
DR Pfam; PF00640; PID; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00629; SHCPIDOMAIN.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 70..206
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 391..482
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 320..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 486 AA; 53671 MW; 067458C3C20C6D5A CRC64;
MPAYGQGNQE DKEESPPPPQ TAILGIYIFL PPIAGCAYWR GLLFSQRLHF TFVCQLAPQW
VGAVSESLWR YTGLSAFTRS DSLGQKLKYH PWISQPPSKV LSNILGKSNL QFAGMSISLT
ISTASLNLRT PDSKQIIANH HMQSISFASG GDPDTTDYVA YVAKDPVNRR ACHILECCDG
LAQDVIGSIG QAFELRFKQY LQCPSKIPAL QDRMQSLDEP WTEEEGDGPD HPYYNSVPSK
MPPPGGFLDA RLKARPHGPD AAQFAGKEQT YYQGRHLGDT FGEDWQRAPT RQGSLDIYST
PEGKAHMALV GETPTYVNTQ PVPPHVWPTA SSSTESSPRK DLFDMKPFED ALKNQPLGPV
LSKAASVECI SPVSPRAPDA KTLEELDAEP WYQGEMSRKE AEALLQEDGD FLVRKSTTNP
GSFVLTGMHN GQAKHLLLVD PEGTIRTKDR VFDSISHLIN YHLESSLPIV SAGSELCLQQ
PVERKH
//
