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Database: UniProt
Entry: G3HJA7_CRIGR
LinkDB: G3HJA7_CRIGR
Original site: G3HJA7_CRIGR 
ID   G3HJA7_CRIGR            Unreviewed;      1965 AA.
AC   G3HJA7;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   07-JUN-2017, entry version 37.
DE   SubName: Full=Ryanodine receptor 1 {ECO:0000313|EMBL:EGV93017.1};
GN   ORFNames=I79_010749 {ECO:0000313|EMBL:EGV93017.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV93017.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
RA   Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
RA   Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
RA   Quake S.R., Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell
RT   line.";
RL   Nat. Biotechnol. 29:735-741(2011).
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DR   EMBL; JH000426; EGV93017.1; -; Genomic_DNA.
DR   InParanoid; G3HJA7; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0006936; P:muscle contraction; IEA:InterPro.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR033215; RyR1.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   PANTHER; PTHR13715:SF97; PTHR13715:SF97; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 1.
DR   Pfam; PF02026; RyR; 1.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001075};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:EGV93017.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1629   1652       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1713   1736       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1773   1794       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1846   1869       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      122    332       RYDR_ITPR. {ECO:0000259|Pfam:PF01365}.
FT   DOMAIN      594    663       RyR. {ECO:0000259|Pfam:PF02026}.
FT   DOMAIN     1444   1493       EF-hand. {ECO:0000259|Pfam:PF13833}.
FT   DOMAIN     1570   1654       RR_TM4-6. {ECO:0000259|Pfam:PF06459}.
FT   DOMAIN     1734   1875       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1965 AA;  221747 MW;  C058DFCA0202EEFC CRC64;
     MPSCQPPGIQ LEGEEEEPEE ETTLGSRLMS LLEKVRLVKK KEEKLEEEPA AEEHKPQSLQ
     ELVSHTVVRW AQEDFVQSPE LVRAMFSLLH YDGLGELLRA LPRAYTISLS SVEDTMSLLE
     CLGQIRSLLI VQMGPQEENL MIQSIGNIMN NKVFYQHPNL MRALGMHETV MEVMVNVLGG
     GESKEIRFPK MVTSCCRFLC YFCRISRQNQ RSMFDHLSYL LENSGIGLGM QGSTPLDVAA
     ASVIDNNELA LALQKQDLEK VVSYLAGCGL QSCPMLLAKG YPDIGWNPCG GERYLDFLRF
     AVFVNGESVE ENANVVVRLL IRKPECFGPA LRGEGGSGLL AAIEEAIRIS EDPARDGPGV
     RRGRRRERFG EEPPEENRVH LGHAIMSFYA ALIDLLGRCA PEMHLIQAGK GEALRIRAIL
     RSLVPLDDLV GIISLPLQIP TLGKDGALVQ PKMSASFVPD HKASMVLFLD RVYGIENQDF
     LLHVLDVGFL PDMRAAASLD TLLTNHYERC WKYYCLPTGW ANFGVTSEEE LHLTRKLFWG
     IFDSLAHKKY DQELYRIAMP CLCAIAGALP PDYVDASYSS KTEKKATVDA EGNFDPRPVE
     TLNVIIPEKL DSFINKFAEY THEKWAFDKA STGIQNNWSY GENVDEELKT HPMLRPYKTF
     SEKPLVEVLP VEPVETREAE GAFLLVPFHQ LCFRWLPQDK EIYRWPIKES LKAMIAWEWT
     VEKAREGEEE KTEKKKTRKI SQTAQVSLPG GSAGLSKGRE GPGRVGGLKD RELDTSSIEK
     RFAFGFLQQL LRWMDISQEF IAHLEAVVSS GRVEKSPHEQ EIKFFAKILL PLINQYFTNH
     CLYFLSTPAK VLGSGGHASN KEKEMITSWF PGTDAPAVVN CLHILARSLD ARTVMKSGPE
     IVKAGLRSFF ESASEDIEKM VENLRLGKVS QARTQVKGVG QNLTYTTVAL LPVLTTLFQH
     IAQHQFGDDV ISRLAAAMPV AFLEPQLNEY NACSVYTTKS PRERARGRNG KEAVVCTLYK
     LRSRFGLHSN CDPSPVVHAF NPSTWLAEAS RSLHRACNMF LESYKASWIL TEDHSFEDRM
     IDDLSLSWGP PGIKLDEDYL YMAYADIMAK SCHLEEGGEN GEEGEEEASE VSFEEKEMEK
     QRLLYQQSRL HNRGAAEMVL QMISACKGET GAMVSSTLKL GISILNGGNA EVQQKMLDYL
     KDKKEVGFFQ SIQALMQTCS VLDLNAFERQ NKAEGLGMVN EDGTGEKVMA DDEFTQDLFR
     FLQLLCEGHN NGEEDSGQGV EDTESISDFY WYYSGKDVIE EQGKRNFSKA MSVAKQVFNS
     LTEYIQENYT MGRKWHLCVP ENNTDAAMGN FDGGFCECSI RHHAGDALAS YFPRMAYQKA
     HAPAALPLEL PHGNVVNGMI ARQMVDMLVE SSSNVEMILK FFDMFLKLKD IVGSEAFQDY
     VTDPRGLISK KDFQKAMDSQ KQFSGPEIQF LLSCSEADEN EMINCEEFAN RFQEPARDIG
     FNVAVLLTNL SEHVPHDPRL RNFLELAESI LEYFRPYLGR IEIMGSSRRI ERIYFEISET
     NRAQWEMPQV SDSPPGEDDI EGSGAGDMSG AGSGGGSGWG SGAGEEMEGD EDENMVYYFL
     EESTGYMEPA LWCLSLLHTL VAFLCIIGYN CLKVRRHLSF PSNYWDKFVK RKVLDKHGDI
     FGRERIAELL GMDLASLEIT AHNELRTDPP PGLLTWIMSI DVSFLYLGWY MVMSLLGHYN
     NFFFAAHLLD IAMGVKTLRT ILSSVTHNGK QLVMTVGLLA VVVYLYTVVA FNFFRKFYNK
     SEDEDEPDMK CDDMMTVGVR AGGGIGDEIE DPAGDEYELY RVVFDITFFF FVIVILLAII
     QGLIIDAFGE LRDQQEQVKE DMETKCFICG IGSDYFDTTP HGFETHTLEE HNLANYMFFL
     MYLINKDETE HTGQESYVWK MYQERCWDFF PAGDCFRKQY EDQLS
//
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