ID G3HJH0_CRIGR Unreviewed; 475 AA.
AC G3HJH0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Tubulin epsilon 1 {ECO:0000313|Ensembl:ENSCGRP00001010826.1};
DE SubName: Full=Tubulin epsilon chain {ECO:0000313|EMBL:EGV94982.1, ECO:0000313|RefSeq:XP_027257943.1};
GN Name=Tube1 {ECO:0000313|Ensembl:ENSCGRP00001010826.1,
GN ECO:0000313|RefSeq:XP_027257943.1};
GN ORFNames=I79_010815 {ECO:0000313|EMBL:EGV94982.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV94982.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGV94982.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSCGRP00001010826.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:XP_027257943.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027257943.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_027257943.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the tubulin family.
CC {ECO:0000256|ARBA:ARBA00009636, ECO:0000256|RuleBase:RU000352}.
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DR EMBL; JH000430; EGV94982.1; -; Genomic_DNA.
DR RefSeq; XP_003503925.1; XM_003503877.3.
DR RefSeq; XP_027257943.1; XM_027402142.2.
DR STRING; 10029.G3HJH0; -.
DR PaxDb; 10029-XP_007627639-1; -.
DR Ensembl; ENSCGRT00001015052.1; ENSCGRP00001010826.1; ENSCGRG00001012631.1.
DR GeneID; 100756741; -.
DR KEGG; cge:100756741; -.
DR CTD; 51175; -.
DR eggNOG; KOG1375; Eukaryota.
DR GeneTree; ENSGT00940000155723; -.
DR OMA; KRAHLHH; -.
DR OrthoDB; 5480452at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP000694386; Unplaced.
DR Proteomes; UP001108280; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR CDD; cd02190; epsilon_tubulin; 1.
DR Gene3D; 1.10.287.600; Helix hairpin bin; 1.
DR Gene3D; 3.40.50.1440; Tubulin/FtsZ, GTPase domain; 1.
DR InterPro; IPR004057; Epsilon_tubulin.
DR InterPro; IPR008280; Tub_FtsZ_C.
DR InterPro; IPR000217; Tubulin.
DR InterPro; IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
DR InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR InterPro; IPR023123; Tubulin_C.
DR InterPro; IPR017975; Tubulin_CS.
DR InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR PANTHER; PTHR11588; TUBULIN; 1.
DR PANTHER; PTHR11588:SF13; TUBULIN EPSILON CHAIN; 1.
DR Pfam; PF00091; Tubulin; 1.
DR Pfam; PF03953; Tubulin_C; 1.
DR PRINTS; PR01519; EPSLNTUBULIN.
DR PRINTS; PR01161; TUBULIN.
DR SMART; SM00864; Tubulin; 1.
DR SMART; SM00865; Tubulin_C; 1.
DR SUPFAM; SSF55307; Tubulin C-terminal domain-like; 1.
DR SUPFAM; SSF52490; Tubulin nucleotide-binding domain-like; 1.
DR PROSITE; PS00227; TUBULIN; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU000352};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|RuleBase:RU000352};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000352};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT DOMAIN 49..277
FT /note="Tubulin/FtsZ GTPase"
FT /evidence="ECO:0000259|SMART:SM00864"
FT DOMAIN 279..414
FT /note="Tubulin/FtsZ 2-layer sandwich"
FT /evidence="ECO:0000259|SMART:SM00865"
SQ SEQUENCE 475 AA; 52855 MW; 2A08D99C4E5DD514 CRC64;
MTQSVVVQVG QCGNQIGCCF WDLALREHAA VNQKGIYDDA ISNFFRNVDT RVVSDGDSIS
KGRISSLKAR AVLIDMEEGV VNEILQGPLR DVFDSKQLIT DISGSGNNWA VGHKVFGSLY
QEQILEKLRK SAEHCDCLQC FFIIHSMGGG TGSGLGTFLL KVLEDEFPEV YRFVTAVYPS
NEDDVITSPY NSMLAMKELN EHADCVLPID NQSLFDIISK IDLVVNSGKL GTTVKPKSLV
TSNVGTVTKR HKKPFDAMNN IVANLLLSLT SSARFEGSLN MDLNEISMNL VPFPQLHYLV
SSLTPLYTLA DVNIPPRRLD QMFSDAFSKD HQLIQADPRH SLYLACALIV RGNVQISDLR
RNIERLKPAL QFVSWNQEGW KTSLCSVPPV GHSHSLLALA NNTCVKPTFM ELRERFMRLY
KKKAHLHHYL QVDGMEESAF AEAVSSLSAL IQEYNELDAT KSMPVPDVPR LSVAM
//
