ID G3HLX5_CRIGR Unreviewed; 563 AA.
AC G3HLX5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Coenzyme A synthase {ECO:0000313|EMBL:EGW08047.1, ECO:0000313|Ensembl:ENSCGRP00001017607.1, ECO:0000313|RefSeq:XP_027283911.1};
GN Name=Coasy {ECO:0000313|Ensembl:ENSCGRP00001017607.1,
GN ECO:0000313|RefSeq:XP_027283911.1, ECO:0000313|RefSeq:XP_035303439.1};
GN ORFNames=I79_011719 {ECO:0000313|EMBL:EGW08047.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW08047.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGW08047.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSCGRP00001017607.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:XP_027283911.1, ECO:0000313|RefSeq:XP_035303439.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027283911.1,
RC ECO:0000313|RefSeq:XP_035303439.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_027283911.1,
RC ECO:0000313|RefSeq:XP_035303439.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; JH000499; EGW08047.1; -; Genomic_DNA.
DR RefSeq; XP_003504702.1; XM_003504654.3.
DR RefSeq; XP_007618451.1; XM_007620261.2.
DR RefSeq; XP_016823504.1; XM_016968015.1.
DR RefSeq; XP_016832233.1; XM_016976744.1.
DR RefSeq; XP_027283911.1; XM_027428110.2.
DR RefSeq; XP_035303439.1; XM_035447548.1.
DR STRING; 10029.G3HLX5; -.
DR PaxDb; 10029-XP_007618451-1; -.
DR Ensembl; ENSCGRT00001021851.1; ENSCGRP00001017607.1; ENSCGRG00001017604.1.
DR GeneID; 100757898; -.
DR KEGG; cge:100757898; -.
DR CTD; 80347; -.
DR eggNOG; KOG3220; Eukaryota.
DR eggNOG; KOG3351; Eukaryota.
DR GeneTree; ENSGT00550000075078; -.
DR OMA; TQCLQSY; -.
DR OrthoDB; 460288at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP000694386; Unplaced.
DR Proteomes; UP001108280; Chromosome 7.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:Ensembl.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004140; F:dephospho-CoA kinase activity; IEA:Ensembl.
DR GO; GO:0004595; F:pantetheine-phosphate adenylyltransferase activity; IEA:Ensembl.
DR GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:Ensembl.
DR CDD; cd02022; DPCK; 1.
DR CDD; cd02164; PPAT_CoAS; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00376; Dephospho_CoA_kinase; 1.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR001977; Depp_CoAkinase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00152; dephospho-CoA kinase; 1.
DR PANTHER; PTHR10695:SF64; BIFUNCTIONAL COENZYME A SYNTHASE; 1.
DR PANTHER; PTHR10695; DEPHOSPHO-COA KINASE-RELATED; 1.
DR Pfam; PF01121; CoaE; 1.
DR Pfam; PF01467; CTP_transf_like; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51219; DPCK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..563
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041117316"
FT DOMAIN 195..338
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
SQ SEQUENCE 563 AA; 61941 MW; 0FF37E3786119561 CRC64;
MAVFRSGLLV LTTPLATLAP RLPPILTSAA RLVNHTLYVH LQPGMDLGGA AQPQASPVQA
TFEVLDFITH FYSGADLHRQ LDVRILLTNI QTKSTFFPVL PSVQNLAHPP EVVMTDFQTL
DGSQYNPVKQ HLERYATSCY SCCSQLSSVL LYPDYGTGEL PVESPSALLP STIRPASPVA
RSPKQPVRGY RRGAVGGTFD RLHNAHKVLL SVACVLAQEQ LVVGVADKDL LKSKLLPELL
QPYGERVDHL SEFLVDIKPS LTFEIVSLLD PYGPAGSDPT LEFLVVSEET YRGGMAVNRF
RLENGKEELA LYQIQLMKDQ NHGENEEDKV SSSSLRQRIL GNLLQPPNLR PELPSGLYVL
GLTGISGSGK SSVAQRLKNL GAYIIDSDLL GHRAYAPGGP AYQPVVEAFG TDILHKDGTI
NRKVVGSRVF GNKKQLKTLT DIMWPVIGKL AREEMDLAVT KGKTVCVIDA AMLLEAGWQN
MVHEVWTIVI PETEAVRRIV ERDGLSEAAA QSRLQSQMSG QQLVEHSHVV LSTLWEPQVT
QQQVEKAWSL LQNRLPKTHQ TKS
//
