ID   G3HM81_CRIGR            Unreviewed;       900 AA.
AC   G3HM81;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   SubName: Full=Klotho {ECO:0000313|EMBL:EGV98875.1};
GN   ORFNames=I79_011830 {ECO:0000313|EMBL:EGV98875.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV98875.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA   Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA   Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA   Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL   Nat. Biotechnol. 29:735-741(2011).
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DR   EMBL; JH000505; EGV98875.1; -; Genomic_DNA.
DR   AlphaFoldDB; G3HM81; -.
DR   STRING; 10029.G3HM81; -.
DR   PaxDb; 10029-XP_007609982-1; -.
DR   eggNOG; KOG0626; Eukaryota.
DR   InParanoid; G3HM81; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.80; Glycosidases; 2.
DR   InterPro; IPR001360; Glyco_hydro_1.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR10353; GLYCOSYL HYDROLASE; 1.
DR   PANTHER; PTHR10353:SF10; KLOTHO; 1.
DR   Pfam; PF00232; Glyco_hydro_1; 3.
DR   PRINTS; PR00131; GLHYDRLASE1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        870..891
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   900 AA;  104264 MW;  992822E8DAA60D33 CRC64;
     MADPTQLGPN DVASDSYNNV YRDTEGLREL GVTHYRFSIS WARVLPNGTV GAPNREGLRY
     YRRLLERLRE LGVQPVVTLY HWDLPQRLQD AYGGWANRAL ADHFRDYAEL CFRHFGGQVK
     YWITIDNPYV VAWHGYATGR LAPGVRGSSR LGYLVAHNLL LAHAKVWHLY NTSFRPTQGG
     QVSIALSSHW ISPRRMTDHN IRECQKSLDF VLGWFAKPIF IDGDYPESMK SNLSSLLPDF
     TESEKKFIKG TADFFALSFG PTLSFQLLDP HMKFHQLESP SLRQLLSWID LEYNHPQIFI
     VENGWFVSGT TKRDDAKYMY YLKKFIMETL KAIRLDGVDV IGYTAWSLMD GFEWHRGYSI
     RRGLFYVDFL SQDKVLLPKS SALFYQKLIE NNGFPPLPEN QPLEGTFPCG FAWGVADNYI
     QVDTTLSQFT DPNIYLWDVH HSKRLIKVDG VVGKRRKPYC VDFSAIRPQI ALLREVHVTH
     FRFSLDWALI LPLGNQTQVN RTVLHFYRCV ISELVRANIT PVVALWQPAA PHQGLPHVLA
     KQGAWENPHT ALAFADYANL CFKELGHRVK FWITINEPNT RNMTYRAGHH LLKAHALAWR
     LYDEKFRAAQ KGKISIALQA DWIEPACSFS QKDKEVAERV LEFDIGWLAE PIFGSGDYPR
     VMRDWLNQKN NFLLPYFTED EEKIIRGSFD FLALSHYTTI LVDWEKEDPI KYNDYLDVQE
     MTDITWLNSP SQVAVVPWGL RKVLNWMRFK YGDVPMYVTA NGIDDDPHAE QDALRTYYVE
     SYVNEALKAY VLDGINLRGY FAYSLSDRSA PKFGFYRYAV NQFEPKPSMR HYRKIVDNNG
     FLGSETQGRL CPEEYTVCTE CSFFHTRKSL LIFLAFLVFA FIISLSLIFY YSKKGRRSYK
//