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Database: UniProt
Entry: G3HNS9_CRIGR
LinkDB: G3HNS9_CRIGR
Original site: G3HNS9_CRIGR 
ID   G3HNS9_CRIGR            Unreviewed;      2535 AA.
AC   G3HNS9;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   25-OCT-2017, entry version 32.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|EMBL:EGW04830.1};
GN   ORFNames=I79_012424 {ECO:0000313|EMBL:EGW04830.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW04830.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
RA   Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
RA   Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
RA   Quake S.R., Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell
RT   line.";
RL   Nat. Biotechnol. 29:735-741(2011).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; JH000552; EGW04830.1; -; Genomic_DNA.
DR   ProteinModelPortal; G3HNS9; -.
DR   InParanoid; G3HNS9; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   PANTHER; PTHR13715; PTHR13715; 4.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF02026; RyR; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001075};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:EGW04830.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1642   1666       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1687   1706       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1906   1926       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1981   2000       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2125   2147       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2199   2220       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1430   1465       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     1819   1851       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2535 AA;  289240 MW;  C95CCAC822C2679D CRC64;
     MGNAIMTFYA ALIDLLGRCA PEMHLIHAGK GEAIRIRSIL RSLIPLGDLV GVISIAFQMP
     TIAKDGKVVE PDMSAGFCPD HKAAMVLFLD RVYGIEVQDF LLHLLEVGFL PDLRAAASLD
     TAALSATDMA LALNRYLCTA VLPLLTRCAP LFAGTEHHAS LIDSLLHTVY RLSKGCSLTK
     AQRDSIEVCL LSICGQLRPS MMQHLLRRLV FDVPQLNEHA KMPLKEKEIY RWPIKESLKT
     MLAWGWRIER TREGDSMALY NRTRRISQTS QAMAEMMAEN YHNIWAKKKK MELESKGGGN
     HPLLVPYDTL TAKEKAKDRE KAQDIFKFLQ ISGYAVSRQV DTHLVGFKDL DLDTPSIEKR
     FAYSFLQQLI RYVDEAHQYI LEFDGGSRSK GEHFPYEQEI KFFAKVVLPL IDQYFKNHRL
     YFLSAASRPL CTGGHASNKE KEMVTRIIMS AKIKIWDSRV TGNDATSIVN CLHILGQTLD
     ARTVMKTGLD SVKSALRAFL DNAAEDLEKT MENLKQGQFT HTRSQPKGVT QIINYTTVAL
     LPMLSSLFEH IGQHQFGEDL ILEDVQVSCY RILTSLYALG TSKSIYVERQ RSALGECLAA
     FAGAFPIAFL ETHLDKHNVY SIYNTRSSRE RAALSLPANV EDVCPNIPSL EKLMAEIIEL
     AESGIRYTQM PHMMEVVLPM LCSYMSRWWE HGPENHPERA EMCCTALNSE HMNTLLGNIL
     KIIYNNLGID EGAWMKRLAV FSQPIINKVK PQLLKTHFLP LMEKLKKKAA MVVSEEDHLK
     AEARGDMSEA ELLILDEFTT LARDLYAFYP LLIRFVDYNR AKWLKEPNPE AEELFRMVAE
     VFIFWSKSHN FKREEQNFVV QNEINNMSFL ITDTKSKMSK AAVSDQERKK MKRKGDRYSM
     QTSLIVAALK RLLPIGLNIC APGDQELIAL AKNRFSLLED PAIRWQMALY KDLPNRTEDT
     SDPERTVERV LDIANVLFHL EQVEHPQRSK KAVWHKLLSK QRKRAVVACF RMAPLYNLPR
     HRAVNLFLQG YEKSWIETEE HYFEDKLIED LAMPGTEPPE EDEATKRVDP LHQLILLFSR
     TALTEKCKLE EDFLYMAYAD IMAKSCHDEE DDDGEEEVKS FEEKEMEKQK LLYQQARLHD
     RGAAEMVLQT ISASKGETGP MVAATLKLGI AILNGGNSTV QQKMLDYLKE KKDVGFFQSL
     AGLMQSCSVL DLNAFERQNK AEGLGMVTEE GSGEKVLQDD EFTCDLFRFL QLLCEGHNSD
     FQNYLRTQTG NNTTVNIIIS TVDYLLRVQE SISDFYWYYS GKDIIDEQGQ RNFSKAIQVA
     KQVFNTLTEY IQGPCTGNQQ SLAHSRLWDA VVGFLHVFAH MQMKLSQDSS QIELLKELMD
     LQKDMVVMLL SMLEGNVVNG TIGKQMVDML VESSNNVEMI LKFFDMFLKL KDLTSSDTFK
     EYDPDGKGVI SKRDFHKAME SHKHYTQSET EFLLSCAETD ENETLDYEEF VKRFHEPAKD
     IGFNVAVLLT NLSEHMPNDT RLQTFLELAE SVLNYFQPFL GRIEIMGSAK RIERVYFEIS
     ESSRTQWEKP QVKESKRQFI FDVVNEGGEK EKMELFVNFC EDTIFEMQLA AQISESDLNE
     RSANKEESEK ERPEEQGPRM GFFSLLTIQS ALFALRYNVL TLVRMLSLKS LKKQMKRMKK
     MTVKDMVTAF FSSYWSVFVT LLHFVASVCR GFFRIVSSLL LGGSLVEGAK KIKVAELLAN
     MPDPTQDEVR GDEEEGERKP LESALPSEDL TDLKELAEES DLLSDIFGLD LKREGGQYKL
     IPHNPNAGLS DLMTNPIPVP EVQEKFQEQK AKEEKEEKEE TKSEPEKAEG EDGEKEEKAK
     DDKGKQKLRQ LHTHRYGEPE VPESAFWKKI IAYQQKLLNY FARNFYNMRM LALFVAFAIN
     FILLFYKVST SSVVEGKELP ARSSSDTAKV TTSLDSNPHR IIAVHYVLEE SSGYMEPTLR
     ILAILHTVIS FFCIIGYYCL KVPLVIFKRE KEVARKLEFD GLYITEQPSE DDIKGQWDRL
     VINTQSFPNN YWDKFVKRKV MDKYGEFYGR DRISELLGMD KAALDFSDAR EKKKPKKDSS
     LSAVLNSIDV KYQMWKLGVV FTDNLVLTVG LLAVVVYLYT VVAFNFFRKF YNKSEDGDTP
     DMKCDDMLTC YMFHMYVGVR AGGGIGDEIE DPAGDEYEIY RIIFDITFFF FVIVILLAII
     QGKPYPAVTP GYFDHDSSAA EARMQGLIID AFGELRDQQE QVKEDMETKC FICGIGNDYF
     DTVPHGFETH TLQEHNLANY LFFLMYLINK DETEHTGQGI FAQNRPEWVI SELACYTYSM
     VAVPLYNTWG AETIIYIINK ADIPVVICDT HQKATMLIEN VEKGLMPGLK TVIIMDPFDA
     ELTERGEKSG IEIFFLYDAE NLGKENFKKP VPPKPENLSA VCFTSGTTGD PKGAMITYQN
     VVSNMAALLR LLEPIFHPTP EDVTISYLPV AHMFERVVQA VIFSCGGKVG FFQGDIWLLP
     DCMKVLKPTV FLTMP
//
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