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Database: UniProt
Entry: G3HQF0_CRIGR
LinkDB: G3HQF0_CRIGR
Original site: G3HQF0_CRIGR 
ID   G3HQF0_CRIGR            Unreviewed;       738 AA.
AC   G3HQF0;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   10-MAY-2017, entry version 34.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   ORFNames=I79_013050 {ECO:0000313|EMBL:EGW09055.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW09055.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
RA   Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
RA   Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
RA   Quake S.R., Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell
RT   line.";
RL   Nat. Biotechnol. 29:735-741(2011).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; JH000610; EGW09055.1; -; Genomic_DNA.
DR   InParanoid; G3HQF0; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0006936; P:muscle contraction; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028812; Na_channel_a7su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   PANTHER; PTHR10037:SF269; PTHR10037:SF269; 1.
DR   Pfam; PF00520; Ion_trans; 3.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001075};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:EGW09055.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     68     96       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    196    215       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    235    254       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    322    340       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    352    370       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    382    401       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    436    467       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    543    569       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN        2    103       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      195    308       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      320    567       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   738 AA;  85185 MW;  18EA03C676E9ED87 CRC64;
     MLSFAAIGQM LGSQCPEGYV CVKEGTNPDN GFTSFDNFGW AFFALFRLMT QDYPELLYHQ
     ILYASGKVYM IFFVVISFWF AFYMASLFLG ILAMTYEKEK QRVSQKPRDV ELKLQQTMKE
     NEEGNEATKM KTTEIEMKKR SPTSANTTLD ILEETTLRQE EGYERKSSPA QVSRESRNGN
     IWKNMRKTCC KIVENSWFKC FIGIVTLLST GTLALEDIYI DQRKTIKILL EYADMIFAYI
     FILEMLLKWV AYGFKAYFSN GWYKLDFMVI IVFCLSLIGK TREDLNPLTS IKFLRALRVL
     SQFERMKNKF QGFTFDLVTH RVFNIIIIVL ICFQATTIMI RNDEQSPQME TALYWMDSLF
     VTLYTLECIL KLTAFHCHYF TSVWNVHDFM VVIFSITGLL LPMTIGQYFV PTSLVQLILL
     SRVIHILRPG KGPKVFFYLM LPLMLSLPAL LNISLLIFLV MFIYAIFGMY NFAYVKKEAG
     INDVSNFETF GSSMLCLFQV TIFSGWDGML NAIFISQWSD CDPDKINPGT QVRGDCGSPS
     VGIFYFVSYI LITWLIIVNM YIVLITEFLS IPFKKKNRSL SEDDFKKFFQ VWNRFDPDRT
     QYIDSSKLSD FAAALDPPLF MAKPNKGQLV AMDLPMAAGD RIHCLDILLA FTKRVMGKDE
     RVEKILSEIE SGFILANPFK ITYEPITTTL KRKQEAVSAT IIQRAYKSYR LRQSDKNTSD
     IPIIDDDRDD PTLSSLTK
//
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