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Database: UniProt
Entry: G3HQV8_CRIGR
LinkDB: G3HQV8_CRIGR
Original site: G3HQV8_CRIGR 
ID   G3HQV8_CRIGR            Unreviewed;      1929 AA.
AC   G3HQV8;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   07-JUN-2017, entry version 33.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   ORFNames=I79_013214 {ECO:0000313|EMBL:EGW00832.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW00832.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
RA   Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
RA   Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
RA   Quake S.R., Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell
RT   line.";
RL   Nat. Biotechnol. 29:735-741(2011).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; JH000620; EGW00832.1; -; Genomic_DNA.
DR   InParanoid; G3HQV8; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008053; Na_channel_a5su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01666; NACHANNEL5.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001075};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:EGW00832.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26   1929       Sodium channel protein. {ECO:0000256|SAM:
FT                                SignalP}.
FT                                /FTId=PRO_5003444578.
FT   TRANSMEM    154    173       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    277    297       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    412    440       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    682    700       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    712    733       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    802    825       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    845    862       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    882    905       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1118   1137       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1158   1174       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1186   1207       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1235   1261       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1357   1383       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1442   1460       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1472   1490       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1502   1522       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1559   1587       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1662   1685       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      159    446       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      459    631       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      682    909       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      919   1113       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1117   1391       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1441   1695       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      437    468       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1929 AA;  217986 MW;  3BE1D90D2F6B54E8 CRC64;
     MLVSGGGGTM TVMWTVFSMW VLGTTEVPSL PPRQPEEILC PQKQDEKMAN FLLPRGTSSF
     RRFTRESLAA IEKRMAEKQA RGSATSQESR EGLPEEEAPQ PQLDLQASKK LPDLYGNPPR
     ELIGEPLEDL DPFYSTQKTF IVLNKGKTIF RFSATNAFMF IMCTILTNCV FMAQHDPPPW
     TKYVEYTFTA IYTFESLVKI LARGFCLHAF TFLRDPWNWL DFSVIVMAYT TEFVDLGNVS
     ALRTFRVLRA LKTISVISGL KTIVGALIQS VKKLADVMVL TVFCLSVFAL IGLQLFMGNL
     RHKCVRNFTE LNGTNGSVES DGLVWDSLDL YLNDPDNYLL KNGTTDVLLC GNSSDAGTCP
     EGYRCLKAGE NPDHGYTSFD SFAWAFLALF RLMTQDCWER LYQQTLRSAG KIYMVFFMLV
     IFLGSFYLVN LILAVVAMAY EEQNQATIAE TEEKEKRFQE AMEMLKKEHE NRLSLTHGLS
     RTSMKPRSSR GSIFTFRRRD QGSEADFADD ENSTAGESES HRTSLLVPWP LRHPSAQGQH
     SPGTSAPGHV LNGKRNSTVD CNGVVSLLGA GDAEATSPGS HLLRPMVLER PPDTTTPSED
     PGGPQMLTPQ APCADGFEEP GARQRALSAV SVLTSALEEL EESHRKCPPC WNRFAQRYLI
     WECCPLWMSI KQKVKFLVMD PFADLTITMC IVLNTLFMAL EHYNMTAEFE EMLQVGNLVF
     TGIFTAEMTF KIIALDPYYY FQQGWNIFDS IIVILSLMEL GLSRMGNLSV LRSFRLLRVF
     KLAKSWPTLN TLIKIIGNSV GALGNLTLVL AIIVFIFAVV GMQLFGRNYS ELRHRVSDCG
     RLPRWHMMDF FHAFLIIFRI LCGEWIETMW DCMEVSGQSL CLLVFLLVMV IGNLVVLNLF
     LALLLSSFSA DNLTAPDEDG EMNNLQLALA RIQRGLRFVK RTTWDFCCGL LRRQPKKPVA
     LATHSQLPSC ITTPRSPPPP EVEKVPPARK ETRFEEDERP GQGTPGDTEP VCVPIAVAES
     DTDDQEEEDG EDSLGTEEES SKQAPEDSYS EGSTADVTNT ADLLEQIPDL GEDVKDPEDC
     FTEGCVRRCP CCTVDTTQAP GKVWWRLRKT CYRIVEHSWF ETFIIFMILL SSGALAFEDI
     YLEERQTIKV LLEYADKMFT YVFVLEMLLK WVAYGFKKYF TNAWCWLDFL IVDVSLVSLV
     ANTLGFAEMG PIKSLRTLRA LRPLRALSRF EGMRVVVNAL VGAIPSIMNV LLVCLIFWLI
     FSIMGVNLFA GKFGRCINQT EGDLPLNYTI VNNKSECESF NVTGELYWTK VKVNFDNVGA
     GYLALLQVAT FKGWMDIMYA AVDSRGYEEQ PQWEHNLYMY IYFVVFIIFG SFFTLNLFIG
     VIIDNFNQQK KKIRGQDIFM TEEQKKYYNA MKKLGSKKPQ KPIPRPLNKY QGFIFDIVTK
     QAFDVTIMFL ICLNMVTMMV ETDDQSPEKV NILAKVNLLF VAIFTGECIV KMAALRHYYF
     TNSWNIFDFV VVILSIVGTV LSDIIQKYFF SPTLFRVIRL ARIGRILRLI RGAKGIRTLL
     FALMMSLPAL FNIGLLLFLV MFIYSIFGMA NFAYVKWEAG IDDMFNFQTF ANSMLCLFQI
     TTSAGWDGLL SPILNTGPPY CDPNLPNSNG SRGNCGSPAV GILFFTTYII ISFLIVVNMY
     IAIILENFSV ATEESTEPLS EDDFDMFYEI WEKFDPEATQ FIEYLALSDF ADALSEPLRI
     AKPNQISLIN MDLPMVSGDR IHCMDILFAF TKRVLGESGE MDALKIQMEE KFMAANPSKI
     SYEPITTTLR RKHEEVSATV IQRAFRRHLL QRSVKHASFL FRQQAGSGLS DEEAPEREGL
     IAYTLNENFS RRSGPPSSSS ISSTSFPPSY DSVTRATSDN LPVRASDYSR SEDLADFPPS
     PDRDRESIV
//
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